Protein Alignment CG1695 and TBC1D15

DIOPT Version :10

• Sequence 1: NP_728346.2
• Gene: CG1695 / 33046
• FlyBaseID: FBgn0031116
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: XP_006719627.1
• Gene: TBC1D15 / 64786
• HGNCID: 25694
• Length: 699
• Species: Homo sapiens
• Alignment Length: 687
• Identity: 158/687 - (22%)
• Similarity: 256/687 - (37%)
• Gaps: 164/687 - (23%)

  Fly   584 GRIMPDLAADEEGL----TRGKWLAMHEDGVVTGDLELYRLVYFGGVEPELRKEV-----WPYLL 639
            ||.|  :..::||:    :.||  ...:||:::|.|.:            |.|:.     |..|.
Human    15 GRSM--IIYEQEGVYIHSSCGK--TNDQDGLISGILRV------------LEKDAEVIVDWRPLD 63

  Fly   640 GHYDFGSTPEERKKQDETCKHYYETTMSEWLAVEAIVRQREKEKTALAVAKLSAEQAR--LAANA 702
            ...|..|....||.         .:::.||       .|..||:.......|::.:|.  :....
Human    64 DALDSSSILYARKD---------SSSVVEW-------TQAPKERGHRGSEHLNSYEAEWDMVNTV 112

  Fly   703 TSSSNPHQKLANGSQQLQLEHGNGEEDQENLVLDEGENDVFDDNDFSDISDPGD----------L 757
            :....||   .||...   .|.||:.....|         |...|...|....:          |
Human   113 SFKRKPH---TNGDAP---SHRNGKSKWSFL---------FSLTDLKSIKQNKEGMGWSYLVFCL 162

  Fly   758 FDEPELGQEAEEQEQSNLEEEVFEKQ----EDEEDQEDHDQREMPRLSEKLVLEFQNIDNMEPLR 818
            .|:..|......|..|.|..|..||.    |..:|:            ..|::..||       :
Human   163 KDDVVLPALHFHQGDSKLLIESLEKYVVLCESPQDK------------RTLLVNCQN-------K 208

  Fly   819 LQENCFADSETENDLGL---GLDSSGNILML-----SIKSSPSTSS---YETVGNEFLDMAEAK- 871
            .....|.:...|...||   ||.....:|..     .||..|.|::   :..|.|...|.....
Human   209 SLSQSFENLLDEPAYGLIQAGLLDRRKLLWAIHHWKKIKKDPYTATMIGFSKVTNYIFDSLRGSD 273

  Fly   872 -LEEEEPPGQLSKFHSADDVRLD-NQDEEESSQPATAVIITEAASLDALDDDPTEEFTSRKTSLM 934
             ...:.||.:::.|.|.....|. ||.||...:..|.:.:.|...:...:....||:|....|..
Human   274 PSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEG 338

  Fly   935 SPLNED----------------------ITVVASLDALQEPKSACVSPASSNGGVYSVELLEQFG 977
            ..||.|                      :......|:.:|.::......:.          |.|.
Human   339 RILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTD----------EYFR 393

  Fly   978 LNLH--------------------RIEKDVQRCDR-NYWYFANEN--LDKLRNVISTYVWEHLDV 1019
            :.|.                    .|||||.|.|| |.:|...:|  |..|.:::.||.....|:
Human   394 MKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDL 458

  Fly  1020 GYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSG-GAMDMHFANMRSLIQILDSEMYD 1083
            ||:|||.||::|||.:.::|..::.||...|::|.:||... ..|......:.:|:::|||....
Human   459 GYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCS 523

  Fly  1084 LMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDII 1148
            .::|. |..:.|||:||.|:.||||..:.|:...|||:|.  .:...:|.|.|..|:||:.:..|
Human   524 YLESQ-DSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWT--ELPCTNFHLLLCCAILESEKQQI 585

  Fly  1149 LSNSMDFTDVIKFFNEMAERHNAQSILQLSRSLVLQL 1185
            :.....|.:::|..||::.:.:.:.||..:.::.||:
Human   586 MEKHYGFNEILKHINELSMKIDVEDILCKAEAISLQM 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN_SGSM1_like	39..233	CDD:439049
		PH_RUTBC	310..485	CDD:275431
		TBC	947..1124	CDD:214540	60/200 (30%)
TBC1D15	XP_006719627.1	PH_RBD	19..219	CDD:432305	49/263 (19%)
		TBC	351..586	CDD:214540	66/247 (27%)