DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1695 and TBC1D15

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	XP_006719627.1	Gene:	TBC1D15 / 64786	HGNCID:	25694	Length:	699	Species:	Homo sapiens

Alignment Length:	687	Identity:	158/687 - (22%)
Similarity:	256/687 - (37%)	Gaps:	164/687 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   584 GRIMPDLAADEEGL----TRGKWLAMHEDGVVTGDLELYRLVYFGGVEPELRKEV-----WPYLL 639
            ||.|  :..::||:    :.||  ...:||:::|.|.:            |.|:.     |..|.
Human    15 GRSM--IIYEQEGVYIHSSCGK--TNDQDGLISGILRV------------LEKDAEVIVDWRPLD 63

  Fly   640 GHYDFGSTPEERKKQDETCKHYYETTMSEWLAVEAIVRQREKEKTALAVAKLSAEQAR--LAANA 702
            ...|..|....||.         .:::.||       .|..||:.......|::.:|.  :....
Human    64 DALDSSSILYARKD---------SSSVVEW-------TQAPKERGHRGSEHLNSYEAEWDMVNTV 112

  Fly   703 TSSSNPHQKLANGSQQLQLEHGNGEEDQENLVLDEGENDVFDDNDFSDISDPGD----------L 757
            :....||   .||...   .|.||:.....|         |...|...|....:          |
Human   113 SFKRKPH---TNGDAP---SHRNGKSKWSFL---------FSLTDLKSIKQNKEGMGWSYLVFCL 162

  Fly   758 FDEPELGQEAEEQEQSNLEEEVFEKQ----EDEEDQEDHDQREMPRLSEKLVLEFQNIDNMEPLR 818
            .|:..|......|..|.|..|..||.    |..:|:            ..|::..||       :
Human   163 KDDVVLPALHFHQGDSKLLIESLEKYVVLCESPQDK------------RTLLVNCQN-------K 208

  Fly   819 LQENCFADSETENDLGL---GLDSSGNILML-----SIKSSPSTSS---YETVGNEFLDMAEAK- 871
            .....|.:...|...||   ||.....:|..     .||..|.|::   :..|.|...|.....
Human   209 SLSQSFENLLDEPAYGLIQAGLLDRRKLLWAIHHWKKIKKDPYTATMIGFSKVTNYIFDSLRGSD 273

  Fly   872 -LEEEEPPGQLSKFHSADDVRLD-NQDEEESSQPATAVIITEAASLDALDDDPTEEFTSRKTSLM 934
             ...:.||.:::.|.|.....|. ||.||...:..|.:.:.|...:...:....||:|....|..
Human   274 PSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEG 338

  Fly   935 SPLNED----------------------ITVVASLDALQEPKSACVSPASSNGGVYSVELLEQFG 977
            ..||.|                      :......|:.:|.::......:.          |.|.
Human   339 RILNVDNMKQMIFRGGLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTD----------EYFR 393

  Fly   978 LNLH--------------------RIEKDVQRCDR-NYWYFANEN--LDKLRNVISTYVWEHLDV 1019
            :.|.                    .|||||.|.|| |.:|...:|  |..|.:::.||.....|:
Human   394 MKLQWKSISQEQEKRNSRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDL 458

  Fly  1020 GYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSG-GAMDMHFANMRSLIQILDSEMYD 1083
            ||:|||.||::|||.:.::|..::.||...|::|.:||... ..|......:.:|:::|||....
Human   459 GYVQGMSDLLSPLLYVMENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCS 523

  Fly  1084 LMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDII 1148
            .::|. |..:.|||:||.|:.||||..:.|:...|||:|.  .:...:|.|.|..|:||:.:..|
Human   524 YLESQ-DSGYLYFCFRWLLIRFKREFSFLDILRLWEVMWT--ELPCTNFHLLLCCAILESEKQQI 585

  Fly  1149 LSNSMDFTDVIKFFNEMAERHNAQSILQLSRSLVLQL 1185
            :.....|.:::|..||::.:.:.:.||..:.::.||:
Human   586 MEKHYGFNEILKHINELSMKIDVEDILCKAEAISLQM 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431
		SRP68-RBD	<648..>713	CDD:304552	11/66 (17%)
		TBC	947..1124	CDD:214540	60/200 (30%)
TBC1D15	XP_006719627.1	DUF3548	19..227	CDD:192931	52/271 (19%)
TBC1D15	XP_006719627.1	TBC	351..586	CDD:214540	66/247 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810