DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1695 and rabgap1l

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	XP_021325262.1	Gene:	rabgap1l / 555272	ZFINID:	ZDB-GENE-050208-389	Length:	1069	Species:	Danio rerio

Alignment Length:	768	Identity:	149/768 - (19%)
Similarity:	258/768 - (33%)	Gaps:	241/768 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   476 DYVFRVVSKCQHEEFLASHPILEL---GRSSPRRKHLGSCSTTGSSDC--------SSKSLSIDQ 529
            |...|:|.:....| :||.||.::   .|         .|..:..|||        ||:...|..
Zfish   205 DGCVRIVDQASGTE-IASFPIYKVLFCAR---------GCEGSVESDCFSFTESYRSSEDFQIHV 259

  Fly   530 SSCETPLIQASQSTSIELVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGLVNGRIMPDLAADE 594
            .||..                   ::.:||..|.:....:..:...|.:    ....:| |:.|.
Zfish   260 FSCHI-------------------KEAVSRILYSFSTAFKRSAKAATEM----QDSPLP-LSPDS 300

  Fly   595 EGLTRGKWLAMHEDGVVTGDLELYRLVYFGGVEPELRKEVWPYLLGHYDFGSTPEERKKQDETCK 659
            :..|....|.:.||.                              |..:|...|::|.      |
Zfish   301 DVFTFSVSLEVREDD------------------------------GKGNFSPVPKDRD------K 329

  Fly   660 HYYETTMSEWLAVEAIVRQREKEKTALAVAKLSAEQARLAANATSSSNPHQKLANGSQQLQLEHG 724
            :|::            :||..::|.::.|.:|:.::..:........:|.||:.|....|.
Zfish   330 YYFK------------LRQGVQKKVSVVVQQLNNKELVIERCFGMLLSPGQKVRNSDMHLL---- 378

  Fly   725 NGEEDQENLVLDEGENDVFDDNDFSDISDPGDLFDEPELGQEAEEQEQSNLEEEVFEKQEDEEDQ 789
                |.|::    |:|........:.|.:|.....:| |.::..:.:|..:...|
Zfish   379 ----DMESM----GKNADGKAYVITGIWNPNTPAFQP-LNEDTPKDKQVYMTVAV---------- 424

  Fly   790 EDHDQREMPRLSEKLVLEFQNIDNMEPLRLQENCFADSETEND-------------LGLGLDSSG 841
                        :.:|.|.     :||:|............|:             ..|.|...
Zfish   425 ------------DLVVTEV-----VEPVRFLMEALVRVYPANERFWYFSRKAFCETFYLKLKQG- 471

  Fly   842 NILMLSIKSSPSTSSYETV--------GNEFLDMAEAKLEEEEPPGQLSKFHSADDVRLDNQDEE 898
                 |:|.|.....||.|        |::.....::..|||||.              ::.|.|
Zfish   472 -----SVKGSQDDMMYEVVSLEKHSECGSQARGRLQSPTEEEEPE--------------EDSDSE 517

  Fly   899 ESSQPATAVIITEAASLDALDDDPTEEFTSRKTSLMSPLNEDITVVASLDALQEPKSACVSPASS 963
            .||           .:.|...|.|.:...|....|.......:|....|.||.:|.    .|.:.
Zfish   518 ISS-----------GTGDVSKDCPEKILESWGGILNRWQGNLLTRPKGLSALVKPG----IPEAL 567

  Fly   964 NGGVYSV--------ELLEQFGLNLHR-------IEKDVQRCDRNYWYF---ANENLDKLRNVIS 1010
            ...|:.:        .||||:.:.:.:       |.:|:.|....:.||   ..:..|.|..:..
Zfish   568 RAEVWQLLSGCHNDQALLEQYRILITKESAQEAVITRDIHRTFPAHDYFKDSGGDGQDSLYKICK 632

  Fly  1011 TYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMI---------ENFPSGGAMDMH 1066
            .|.....::||.||...|.|.||:...:|    ..||.|::.|.         .||.     |:|
Zfish   633 AYSVYDEEIGYCQGQSFLAAVLLLHMPEE----QAFCVLVKIMFNYGLRELYRNNFE-----DLH 688

  Fly  1067 --FANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIAS 1129
              |..:..|:|.|..:::..........|.| ..:|||..|..:.....||...:::     :..
Zfish   689 CKFYQLERLLQELLPDLWSHFQELNLEAHMY-ASQWFLTLFTAKFPLCMVFHITDLL-----LCE 747

  Fly  1130 GHFVLF-LALALLETYRDIILSNSMDFTDVIKFFN-EMAERH----NAQSILQ 1176
            |..::| :|||||:|.::.:|  ..||...:|||. ::.:|:    ||:.:::
Zfish   748 GLNIIFNVALALLKTSKEDLL--QADFEGALKFFRVQLPKRYRAAENARRLME 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431	3/8 (38%)
		SRP68-RBD	<648..>713	CDD:304552	12/64 (19%)
		TBC	947..1124	CDD:214540	47/205 (23%)
rabgap1l	XP_021325262.1	PTB_Rab6GAP	157..285	CDD:269922	21/108 (19%)
		DUF3694	319..450	CDD:315198	30/188 (16%)
		RabGAP-TBC	565..768	CDD:306939	50/217 (23%)
		SMC_N	784..>1042	CDD:330553	3/15 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900