DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1695 and rabgap1l

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_001361730.1	Gene:	rabgap1l / 550007	XenbaseID:	XB-GENE-483580	Length:	1056	Species:	Xenopus tropicalis

Alignment Length:	873	Identity:	165/873 - (18%)
Similarity:	297/873 - (34%)	Gaps:	299/873 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   462 VMEAGGSVTDETP---------------IDYVFRVVSKCQHEEFLASHPILELGRSSPRRKHLGS 511
            |:..|.|.:::.|               ::.:.|...|.|:...| ...|.|...:.|...|.
Frog    24 VLVEGSSDSEDKPEFKIMSNGDEQLEKAMEEILRDSEKTQNSNML-KETITEELSTFPTASHF-- 85

  Fly   512 CSTTGSSDCSSKSLSIDQSSCETPLIQAS---------QSTSIELVC-------STMRRQIIS-R 559
             |.||:.:. ..:|.:|..|.|.| :|::         :|.|...:|       |..|.:|.: |
Frog    86 -SDTGTKNV-PLTLILDPKSTELP-VQSTTVLSHPPEEESVSFHKLCYLGCMKVSAPRNEIEALR 147

  Fly   560 AFYGWLAYCRHLSTVRTHLSGLVNG--RIMPDLAADEEGLTRGKWLAMHEDGVVTGDLELYRLVY 622
            |.....|.|....||..::..:..|  ||:......|                 .....:|::::
Frog   148 AMASMKAQCIAPITVTLYVPNIPEGSVRIIDQTNKSE-----------------IASFPIYKVLF 195

  Fly   623 F-----GGVEPELRKEVWPYLLGHYDFGSTPEERKKQDETCKHYYETTMSEWLAVEAIVRQREKE 682
            .     |..|.:.      :.....|.|:        :|...|.:...:.|  ||..|:
Frog   196 CVRGRDGTSECDC------FAFTERDLGT--------EEFQIHVFSCEIKE--AVSRIL------ 238

  Fly   683 KTALAVAKLSAEQARLAANATSSSNPHQKLANGSQQLQLEHGNGEEDQENLVLDEGENDVF---- 743
            .:.....|.|:.|.                               .|.::..|...::|||
Frog   239 YSFFTAFKRSSRQV-------------------------------SDVKDSALPTPDSDVFTFMV 272

  Fly   744 ------DDN--DFSDI-SDPGDLFDEPELGQEAEEQEQSNLEEEVFEKQEDEEDQEDHDQREMPR 799
                  ||:  :||.: .|...||.:.:.|
Frog   273 SLEVKEDDSKGNFSPVPKDRDKLFFKLKQG----------------------------------- 302

  Fly   800 LSEKLVLEFQNIDNMEPLRLQENCF------------ADSETENDLGLGLDSSGNILMLSIKSSP 852
            :.:|:|:..|.:.|.|  .|.|.||            :|....:...:|..|.|...:::...:|
Frog   303 IEKKVVVTIQQVSNKE--LLVERCFGMLLSPGRNVKNSDMHLLDMESMGKSSDGKAYVITGIWNP 365

  Fly   853 STSSYETVGNE-----------FLDMAEAKLEEE------------------------------- 875
            :..:::.:..|           .:||...::.|.
Frog   366 NIQAFQALNEETPKDKRVYMTVAVDMVVTEVVEPVRFLLETVVRVYPTNERFWYFSRKAFTDTFY 430

  Fly   876 ---EPPGQLSKFHSADDVRLDNQDEEESSQPATAVIITEAASLDALDDDPTEEFTSRKTSLMSPL 937
               :|.|.:....|..:| :..|.:.|..:..|:.:.....|....:|||.||..:...|....:
Frog   431 LKLKPSGNIGVTDSMYEV-VSLQRQSEIEEAPTSPLSASNLSSPQEEDDPEEESDTELWSGTGDV 494

  Fly   938 NED-----------ITVVASLDALQEPK--SACVS---PASSNGGVYSV--------ELLEQFGL 978
            ::|           :.|....:...:||  |:.|.   |.:....|:.:        |:|:::.:
Frog   495 SKDCPEQILDCWGQLLVKWHSNLSVKPKGLSSLVKRGIPEALRAEVWQLLAGCHENQEMLDKYKM 559

  Fly   979 NLHR-------IEKDVQRCDRNYWYFAN------ENLDKLRNVISTYVWEHLD--VGYMQGMCDL 1028
            .:.:       |.:|:.|....:.||.|      |:|.|:..|.|.|     |  :||.|||..|
Frog   560 LVVKDSAQDSVIRRDIHRTFPAHDYFKNTEGDGQESLYKMCKVYSLY-----DEVIGYCQGMSFL 619

  Fly  1029 VAPLLVIFDDESLSYSCFCKLMERMIE----NFPSGGAMDMHFANMRSLIQILDSEMYDLMDSNG 1089
            .|.||:...:|    ..||.|::.|.:    |.......|:| .....|.::|..::.||
Frog   620 AAVLLLHMPEE----QAFCVLVKIMYDYQFRNLYQNNFEDLH-CKFYQLERLLQEQLPDL----- 674

  Fly  1090 DYTHF--------YFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLF-LALALLETYR 1145
             |:||        .:..:|||..|..:.....||...:::     ::.|..::| :|||||:|.:
Frog   675 -YSHFVALNLEAHMYASQWFLSLFTAKFPLCMVFHIMDLL-----LSEGLSIIFHVALALLKTSK 733

  Fly  1146 DIILSNSMDFTDVIKFFN-EMAERHNAQ 1172
            :.:|  ..||...:|||. ::.:|:.|:
Frog   734 EDLL--QADFEGALKFFRVQLPKRYRAE 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431	5/37 (14%)
		SRP68-RBD	<648..>713	CDD:304552	9/64 (14%)
		TBC	947..1124	CDD:214540	51/216 (24%)
rabgap1l	NP_001361730.1	PTB_Rab6GAP	123..251	CDD:269922	28/166 (17%)
		DUF3694	284..415	CDD:372133	24/167 (14%)
		TBC	528..737	CDD:214540	56/229 (24%)
		Smc	753..>1011	CDD:224117	2/7 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910