DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1695 and TBC1D8B

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_060222.2	Gene:	TBC1D8B / 54885	HGNCID:	24715	Length:	1120	Species:	Homo sapiens

Alignment Length:	745	Identity:	150/745 - (20%)
Similarity:	270/745 - (36%)	Gaps:	205/745 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   533 ETPLIQASQSTSIELVCSTMRRQIISRAFYGWLA--YCRHLSTVRTH--LSGLVNGRIMPDLAAD 593
            :||    .....:.:.|...|.:|...  :.||.  ..:.||...::  ::..|.|:|. .|.|:
Human    68 QTP----DSQVYLSIACGANREEITKH--WDWLEQNIMKTLSVFDSNEDITNFVQGKIR-GLIAE 125

  Fly   594 EEGLTRGKWLAMHEDGVVTGDLELYR--LVYFG---GVEPELRKEV----------------WPY 637
            |     ||.....||     |.|.:|  |:.|.   |: ||..|.|                |.|
Human   126 E-----GKHCFAKED-----DPEKFREALLKFEKCFGL-PEKEKLVTYYSCSYWKGRVPCQGWLY 179

  Fly   638 L----LGHYDF--GS------TPEERKKQDET-----------C----KHYYET--------TMS 667
            |    |..|.|  ||      :.:|..|.::|           |    .||:..        .:.
Human   180 LSTNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQTYLLM 244

  Fly   668 EWLAVEAIVRQREKEKTALAVAKLSAEQARLAANATSSSNPHQKLANGSQQLQLEHGNGEEDQEN 732
            |.||..||.|..:||               ...|.....||.|....|.:    ...:.|:....
Human   245 EQLANYAIRRLFDKE---------------TFDNDPVLYNPLQITKRGLE----NRAHSEQFNAF 290

  Fly   733 LVLDEGE-----NDVFDDNDFSDISDPGDL-FDEPELGQEAEEQEQSNL-----EEEVFEKQEDE 786
            ..|.:||     ::.|....||..:..|.: ..|..:...:::..|.::     |....:|..|.
Human   291 FRLPKGESLKEVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAIDKTNDS 355

  Fly   787 EDQEDHDQREMPRLSEKLVLEFQNIDNMEPL--RLQENCFADSETENDLGLGL-------DSSGN 842
                  .:..:..:..|....|..:.:.|.|  :|:..|.|.|...:|:...|       :.|.|
Human   356 ------SKSVIISIKGKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTELAISSESTEPSDN 414

  Fly   843 ILMLSIKSSPSTSSYETVGNEFLDMAEAKLEEEEPPGQLSKFHSADDVRLDNQD-EEESSQPATA 906
            ..:.|:.|....|  :||..|.|               ::.||..:...|:::. :|:..:.:..
Human   415 FEVQSLTSQRECS--KTVNTEAL---------------MTVFHPQNLETLNSKMLKEKMKEQSWK 462

  Fly   907 VIITEAASLDALDDDPTEEFTSRKTSLMSPLNEDITVVASLDALQEPK----SACVSPASSNGGV 967
            ::..|...       ....|.::||       .|:.|....:.|:...    |..|:..::|...
Human   463 ILFAECGR-------GVSMFRTKKT-------RDLVVRGIPETLRGELWMLFSGAVNDMATNPDY 513

  Fly   968 YSVELLEQ----FGLNLHRIEKDVQRCDRNYWYFANE-NLDKLRNVISTYVWEHLDVGYMQGMCD 1027
            |: |::||    ..|....||:|::|....:..|.:: .:..||.|::.|.:.:..:||.|.| :
Human   514 YT-EVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAM-N 576

  Fly  1028 LVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSEMYD--------- 1083
            ::..:|:::..|..::.....:.|||:.:          :.|.|.:..::|..:::
Human   577 ILTSVLLLYAKEEEAFWLLVAVCERMLPD----------YFNRRIIGALVDQAVFEELIRDHLPQ 631

  Fly  1084 LMDSNGDYTHF-YFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHF------VLFLALALL 1141
            |.:...|.|.| .....|||          .:|.:...|.:|.::....|      :|.|.||:|
Human   632 LTEHMTDMTFFSSVSLSWFL----------TLFISVLPIESAVNVVDCFFYDGIKAILQLGLAIL 686

  Fly  1142 ETYRDIILSNSMD---FTDVIKFFNEMAER 1168
            :...|.:|:...|   .|.:.:||:.:..:
Human   687 DYNLDKLLTCKDDAEAVTALNRFFDNVTNK 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431
		SRP68-RBD	<648..>713	CDD:304552	18/87 (21%)
		TBC	947..1124	CDD:214540	39/195 (20%)
TBC1D8B	NP_060222.2	PH-GRAM1_TBC1D8B	156..254	CDD:275419	21/97 (22%)
		PH-GRAM2_TBC1D8B	296..388	CDD:270159	16/97 (16%)
		TBC	486..694	CDD:214540	47/229 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1035..1066
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900