DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1695 and tbc1d15

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	XP_005159143.1	Gene:	tbc1d15 / 492676	ZFINID:	ZDB-GENE-041111-251	Length:	665	Species:	Danio rerio

Alignment Length:	652	Identity:	150/652 - (23%)
Similarity:	243/652 - (37%)	Gaps:	186/652 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   646 STPEERKKQDETCKHYYETTMSEWLAVEAIVRQREKEKTALAVAKLSAEQA----RLAANATSSS 706
            |:|:|.:.||               .:...:|..|||...|...| ..|.|    .|.|...|||
Zfish    20 SSPDESEDQD---------------LISGFLRIVEKEGETLVEYK-PLEDADPSNMLCACKDSSS 68

  Fly   707 ----------NPHQKLANGSQQLQLE---------------HGNGEEDQENLVLDEGENDVFDDN 746
                      |||:.:   ..||..|               |.||         |.|.|.|.:.|
Zfish    69 VVEWTQSSEENPHRPV---DHQLSYETEWDMINAVSFRRKVHANG---------DGGSNHVNEQN 121

  Fly   747 D--FS-DISD-------------------PGDLFDEPELGQEAEEQEQSNLEEEVFEKQEDEEDQ 789
            .  || ::.|                   .|.........|...:....:|.:.|    :..|..
Zfish   122 KRAFSFNVCDLRSVTVKCEGWSYLTFRLKDGTALPAIHFHQGGSKAFLDSLRKSV----QINESP 182

  Fly   790 EDHDQREMPRLSEKLVLEFQN-IDNMEPLRLQENCFADSETENDLGLGLDSSGNILM-------L 846
            :|.....:...|:.....|:| :|:.....:|:....|..| ..|| |.....|.|.       |
Zfish   183 DDESVLIVSTYSKAFSQSFENLLDDTNYGFVQQKFKKDPYT-TTLG-GFSKVTNYLFDAFRAPEL 245

  Fly   847 SIKSSPSTSSYETVGNEFLDMAEAKLEEEEPPGQLSKFHSADDVRLDNQDEEESSQPATAVIITE 911
            ..:..|:....:.:| |.:...|  :.::|.||    |.....:.|..:.|.:.:.|.|   :.|
Zfish   246 ECQQRPAEEVADVLG-ELIPGLE--INQQEEPG----FEVITRLDLGPRPEMQRTGPVT---MEE 300

  Fly   912 AASLDALDDDPTEEFTSRKTSLMSPLNEDITVVASL-------------------------DALQ 951
            .|....|:        .|.|:|  |..:|......|                         ..||
Zfish   301 WAKYQDLE--------GRMTNL--PHLKDAIFKGGLCHAVRKEAWKFLLGYFPWSSTHEERKLLQ 355

  Fly   952 EPKSACVSPASSNGGVYSVELLEQFGLNLH--------------------RIEKDVQRCDRNYWY 996
            :.|:.                 |.|.:.|.                    .|||||.|.|||..:
Zfish   356 KRKTD-----------------EYFRMKLQWKSVSEEQERRNSRLRDYRSLIEKDVNRTDRNNKF 403

  Fly   997 FANENLDK-----LRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIEN 1056
            :  |.||.     |.:::.||.....|:||:|||.||::|:|.:.::|..::.||...|:.|.||
Zfish   404 Y--EGLDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPILFVMENEVDAFWCFVSFMDEMHEN 466

  Fly  1057 FPSG-GAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEV 1120
            |... ..|......:.:|:::||...::.:::. |..:.|||:||.|:.|||||.:.||...|||
Zfish   467 FEEQMQGMKTQLIQLSTLLRLLDLAFWNYLEAQ-DSGYLYFCFRWLLIRFKRELHFQDVLRLWEV 530

  Fly  1121 IWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSILQLSRSLVLQL 1185
            :|.  .:...:|.|.:..|:|::.:..|:.....|.:::|..||::.:.:.:.||..|.|:.:|:
Zfish   531 MWT--RLPCQNFHLLVCCAILDSEKQKIMDRKYGFNEILKHINELSMKLDIEEILSKSESICMQI 593

  Fly  1186 QT 1187
            ::
Zfish   594 KS 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431
		SRP68-RBD	<648..>713	CDD:304552	20/78 (26%)
		TBC	947..1124	CDD:214540	62/227 (27%)
tbc1d15	XP_005159143.1	DUF3548	4..220	CDD:192931	46/231 (20%)
tbc1d15	XP_005159143.1	TBC	322..557	CDD:214540	66/256 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810