DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1695 and tbc1d16

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_001006076.2	Gene:	tbc1d16 / 450056	ZFINID:	ZDB-GENE-041010-179	Length:	717	Species:	Danio rerio

Alignment Length:	994	Identity:	178/994 - (17%)
Similarity:	277/994 - (27%)	Gaps:	493/994 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 SRTTL----LYGKNNVLVLPKDVSEPM-------PGYLSLH----QSIQS-LTIKWTPNQLMNGY 356
            ||:.|    ::.||||.|.|   :||:       ||||.:|    :::.| |.:.|.||..:...
Zfish    27 SRSVLDGEIIFSKNNVCVHP---AEPLPGLPEHHPGYLCVHLEKDETLGSTLILTWVPNSRIQRQ 88

  Fly   357 NDGDGGDKSFYWSYALNINVDEIVYVHCHQNRGGDTGGTIILVGQDGVQRPPIHFPEGGHLQAFL 421
            ::           .||.....|...|..:..|......:          |||. .||...
Zfish    89 DE-----------EALRYITPESSPVRRNPRRRAHRSHS----------RPPA-APEEEE----- 126

  Fly   422 SCLETGLLPHGQLDPPLWSQRGIGKLFPWPKSVRRHILPSVMEAGGSVTDETPIDYVFRVVSKCQ 486
            :..|.|..|..|                           :::|.|...:.|...|
Zfish   127 AADEEGQEPQNQ---------------------------ALLEEGDEGSCELSAD---------- 154

  Fly   487 HEEFLASHPILELGRSSPRRKHLGSCSTTGSSD-C----------SSKSLSIDQSS--CETPLIQ 538
                       |:.|.|.    :||.|.|.||. |          ||.|:.:|..|  |:.|:..
Zfish   155 -----------EVSRDST----IGSDSDTFSSPFCLSPVSEALGESSSSVFLDNESRECDEPMAH 204

  Fly   539 ASQSTS--------------------------IELVCSTMRRQI--------------------- 556
            ::.|.|                          :|.:|...|..:
Zfish   205 SASSASSLDSHAPSESSHSQGVRWEEQQNVMALEHLCGVFRVDLGHMRSLRLFFSDEACTCGQLV 269

  Fly   557 --------------------ISRAFYGWLAYCR------HLSTVRTHLSGLVNGRIMPDLAA-DE 594
                                ::..|..|.. ||      .:|..::.:...:....:|.... .|
Zfish   270 IASRESQYKILHFHHAGLDKLAEVFQQWKC-CRETQLKDQVSDEKSCMQFSIRRPTLPSAEMHPE 333

  Fly   595 EGLTR----GKWLA-MHEDGVVTGDLELYRLVYFGGVEPELRKEVWPYLLGHYDFGSTPEERKKQ 654
            |.|.|    ..||. ::..|.|..:.:|.:.::|||::|.:|.||||:||.:|.:.||.|||
Zfish   334 ERLYRRLDVSSWLRHLNNSGQVLEEYKLRKAIFFGGIDPSIRGEVWPFLLHYYSYDSTSEER--- 395

  Fly   655 DETCKHYYETTMSEWLAVEAIVRQREKEKTALAVAKLSAEQARLAANATSSSNPHQKLANGSQQL 719

Zfish   396 ----------------------------------------------------------------- 395

  Fly   720 QLEHGNGEEDQENLVLDEGENDVFDDNDFSDISDPGDLFDEPELGQEAEEQEQSNLEEEVFEKQE 784

Zfish   396 ----------------------------------------------------------------- 395

  Fly   785 DEEDQEDHDQREMPRLSEKLVLEFQNIDNMEPLRLQENCFADSETENDLGLGLDSSGNILMLSIK 849
                                          |..|||:.
Zfish   396 ------------------------------EAWRLQKR--------------------------- 403

  Fly   850 SSPSTSSYETVGNEFLDMAEAKLEEEEPPGQLSKFHSADDVRLDNQDEEESSQPATAVIITEAAS 914
                        .|:.|:.:.                    ||....||.|
Zfish   404 ------------GEYQDIQQR--------------------RLSMSPEEHS-------------- 422

  Fly   915 LDALDDDPTEEFTSRKTSLMSPLNEDITVVASLDALQEPKSACVSPASSNGGVYSVELLEQFGLN 979
                      ||. ||.                                           ||
Zfish   423 ----------EFW-RKV-------------------------------------------QF--- 430

  Fly   980 LHRIEKDVQRCDRNYWYFA---NENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESL 1041
              .::|||.|.||:..:|.   |.|::.:|.::..|...:.|:||.|||.|||||||....|||.
Zfish   431 --TVDKDVVRTDRSNMFFRGENNPNVEIMRRILLNYAVFNPDMGYCQGMSDLVAPLLTEIQDESD 493

  Fly  1042 SYSCFCKLMERMI-ENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSNG-DYTHFYFCYRWFLLD 1104
            ::.||..|||..| .:.|....|:.....:|.|::::....:..:...| |.....||:||.||.
Zfish   494 TFWCFVGLMENTIFISSPRDEDMERQLMYLRELLRLMLPRFHQHLTRLGEDGLQLLFCHRWVLLC 558

  Fly  1105 FKRELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERH 1169
            ||||....:....||..||  |..:.:|.|||.:|::..|.|.:....:....::..|:.::...
Zfish   559 FKREFPDAEALRMWEACWA--HYQTDYFHLFLCVAIIVLYGDDVTEQQLATDQMLLHFSNLSMHM 621

  Fly  1170 NAQSILQLSRSLVLQLQTI 1188
            |.:.:|:.:|||:.|.:.:
Zfish   622 NGELVLRKARSLLYQFRLL 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431	37/190 (19%)
		SRP68-RBD	<648..>713	CDD:304552	3/64 (5%)
		TBC	947..1124	CDD:214540	54/181 (30%)
tbc1d16	NP_001006076.2	TBC	368..596	CDD:214540	92/524 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810