Protein Alignment CG1695 and plx

DIOPT Version :10

• Sequence 1: NP_728346.2
• Gene: CG1695 / 33046
• FlyBaseID: FBgn0031116
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Alignment Length: 1414
• Identity: 252/1414 - (17%)
• Similarity: 440/1414 - (31%)
• Gaps: 489/1414 - (34%)

  Fly    29 LKERLI-------ASVKKEVKQLM----------EEAVTKKYVHEESSSVTSLCGAVEACLSHGL 76
            :|.||:       |||.......|          .|:.||..|..|:..:.|.....|...||.|
  Fly     1 MKTRLVSLTFRGSASVDPRYSASMLPWTINDIRSTESYTKLSVGIENGILESYNSDFELQFSHPL 65

  Fly    77 RRRALGLFKTSSTTALIQKIAKICPEADYVSRRLLELELAQESHAVSGKRSSCSSDSIIKPKLLS 141
             :..:|:.:      :|.|     |:|..:....|:|:      :.:|:.||.|:.:      .|
  Fly    66 -KHIVGMCR------IIHK-----PQAKSIGNGFLQLK------SSAGQTSSSSAVA------SS 106

  Fly   142 KGSGSSNSVTTINTVTNGAGAGPGGGGGASAPLGKYLWIRLALHEKRLAKIIEHLVSNANSYYDR 206
            .|..:|:|:|               |.|.                                   |
  Fly   107 MGGAASSSLT---------------GNGL-----------------------------------R 121

  Fly   207 EALVADPDYGSILSSLLVGPCALEFTRAKTAD--------------------HYWSDP------- 244
            ..|.|...|||:.||   ..||.:....::|:                    :...||
  Fly   122 HTLTASTSYGSLSSS---AACAYQLQLQQSAEASAEQPQNFMEFQGPITGLVYLLKDPKDPLLHI 183

  Fly   245 ------CADELVQ-RHRI------------------------SSGN---------RTPPTTHRPI 269
                  ..:|:.: .|::                        |.||         .||.|..:..
  Fly   184 YLFECEAVEEMAELMHQMRDPAHTLGGSVGSIPQTLIGGGGGSHGNSNGALNGIHATPATNLKMS 248

  Fly   270 INFKRSLHTSSEDTSSGSFKACSPASVAKDYVESLHQNSRT----TLLYGKNNVLVLPKDVSEPM 330
            ...:.:.|.:|.:..|...||      :|.|...|..:|.|    |....::|:.:| .|:|
  Fly   249 EAMRNAQHDTSPNPVSSKMKA------SKSYTHGLSSSSGTVNIPTSTSAQSNLSLL-ADIS--- 303

  Fly   331 PGYLSLHQSIQSLTIKWTPNQLMNGYND-------------------------GDGG------DK 364
            |.:....:.:....|:.:..::.|.:.|                         .:||      ..
  Fly   304 PNHTHFFEVMYVGKIRVSQKRVPNTFIDDALPKFKAYDAQRLRLLQNRKMSLSSEGGVGIEAKPS 368

  Fly   365 SFYWSYALNINVDEIVYVHCHQNRGGDTGGTIILVGQDGVQRPPIHF------------------ 411
            |...|:.|....:|    ...|::|.|.       .||...:|.:..
  Fly   369 SSLKSHDLKEEDEE----EQEQHKGHDD-------SQDSQAKPLVQLQLTGAEEGAAPRPLEDNK 422

  Fly   412 ----PEGGHLQAFLSCLETGLLPHGQLDPPLWSQRGIGKLFPWPKSVRRHILPSVMEAGGSVTDE 472
                ||...|....|.:|.|...|.....||.:.                   |.:||...:.::
  Fly   423 ENKSPEKRPLLRGQSQIELGHKEHSDGSQPLAAN-------------------SQLEAPNVIVNK 468

  Fly   473 TPIDYVFRVVSKCQHEEFLASHPILELGRSSPRRKHLGSCSTTGSSDCSSKSLSI---------- 527
            .|                           :.||.:.:|    ||::..|:....:
  Fly   469 QP---------------------------TPPRDQGVG----TGTASASAGPSQLHPNYAMDNIP 502

  Fly   528 ---DQSS---CETPLIQASQSTSIELV--C-----STMRRQIISRAFYGWLAYCRHLSTVRTHLS 579
               |:|:   |..|.::.:: |.:.||  |     |..|:|::....:..:|.|.|......|.
  Fly   503 KQRDRSASQGCIPPYVEQNR-TMVFLVGRCDLRLISPDRKQVLLYKDFKDVASCVHGQKSLDHF- 565

  Fly   580 GLVNGRIMPDLAADEEGLTRGKWLAMHEDGVVTGDLELYRLVYFGGVEPELRKEVWPYLLG--HY 642
                |.|..:|               :.||            |.|.|.....:.|...::.  ..
  Fly   566 ----GIICREL---------------NNDG------------YIGYVFKCQSEHVCDDIVAAIAQ 599

  Fly   643 DFGSTPEERKKQDE---TCKH----YYETTMSEWLAVEAIVRQREKEKTALAVAKLSA----EQA 696
            .|.:..|::||||.   :|:|    :|....::   ||.:   .||:..||.:.::..    ||.
  Fly   600 AFDTCAEQKKKQDTQIFSCEHCPMLWYHKLCTD---VEGL---SEKKTQALILRRIETLSDDEQE 658

  Fly   697 RLAANATSSSNPHQKLANGSQQL-QLEHGNGEEDQENLVLDEGENDVFDDNDFSDISDPGDLFDE 760
            .:.|....|...:..:|..:|.| .|...:.|..|:..|.|..||.....|.:
  Fly   659 IVWAKFCGSEKTNSPVAEQNQFLMMLLRAHCESRQQRHVHDTAENRSEFLNQY------------ 711

  Fly   761 PELGQEA----EEQEQSNLEEEVFEKQEDEED--QEDHDQREMPRLSEKLVLEFQNIDNMEPLRL 819
              ||...    .::..:|..:.:.:::..::|  ...|:.|::..            .:.|||..
  Fly   712 --LGGSTIFMKAKRSLTNSFDNLLKRKPSKDDIAVPSHNLRDIRE------------GSAEPLGT 762

  Fly   820 QENCFADSETENDLGLGLDSSGNILMLSIKSSPSTSSYETVGNEFLDMAEAK------------- 871
            |..........|.:|....|......|   .||....:..|||   ...||:
  Fly   763 QSPPEGFRSRSNTVGASPSSKPTAEQL---KSPMMDIFIKVGN---SPKEAETHQGSWRQAILNS 821

  Fly   872 -------LEEEEPPGQLSKFHS-ADDVRLDNQDEEESSQPATAVII------TEAASLDALDDDP 922
                   |:.|.|...||.... |...:.|..:..|..:.|....|      ||.|.|.|..::
  Fly   822 VVTPSKGLDSEVPTEFLSPMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQARQNE- 885

  Fly   923 TEEFTSRKTSLMSPLNEDITVVASLDALQEPKSACVS----------------PASSNGGVYSVE 971
             .|....|......:..|..::...:.:.|..|..:.                |.|..|.|::.
  Fly   886 -NELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTF- 948

  Fly   972 LLEQFGLNL--------------------------HRIEKDVQRCDRNYWYFANE-NLDKLR--N 1007
            |.||..:|.                          |.|..|:.|...|:.::.:. .|.:|.  |
  Fly   949 LAEQHSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFN 1013

  Fly  1008 VISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMER---MIENFPSGGAMDMHFAN 1069
            ::..|.....::||.||: ..:..:|::..||:.|:.....||.|   ..:..|......:....
  Fly  1014 LLKAYSILDPELGYCQGL-GFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQ 1077

  Fly  1070 MRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVL 1134
            :..|::....::|..:|.| |.:...:...|.|..|..:.....|...:::::    :.|...:.
  Fly  1078 LSRLVKDHLPDLYVWLDQN-DVSPTLYAAPWILTVFSSQFPLGFVARVFDLLF----LESSDVIF 1137

  Fly  1135 FLALALLETYRDIILS--NSMDFTDVIKFFNEMAERHNAQSILQLSRSL 1181
            ..|:|||..::..:|:  |..:..|.:|......|....:.|::|..|:
  Fly  1138 KFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSM 1186

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN_SGSM1_like	39..233	CDD:439049	39/203 (19%)
		PH_RUTBC	310..485	CDD:275431	35/231 (15%)
		TBC	947..1124	CDD:214540	40/224 (18%)
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	61/396 (15%)
		DUF3350	831..880	CDD:463365	12/48 (25%)
		TBC	933..1152	CDD:214540	43/225 (19%)
		COG4372	<1190..>1353	CDD:443500