Protein Alignment CG1695 and Tbc1d2

DIOPT Version :10

• Sequence 1: NP_728346.2
• Gene: CG1695 / 33046
• FlyBaseID: FBgn0031116
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: XP_006538109.1
• Gene: Tbc1d2 / 381605
• MGIID: 2652885
• Length: 923
• Species: Mus musculus
• Alignment Length: 615
• Identity: 122/615 - (19%)
• Similarity: 228/615 - (37%)
• Gaps: 143/615 - (23%)

  Fly   646 STPEER-KKQDETCKHYYE------TTMSEWLAVE----AIVRQREKEKTALAVAKLSAEQARLA 699
            |.|.:: |:|..|...:.:      |...:..|:|    .:.::.:.:|..:.:...:.|.|:..
Mouse   282 SGPTQKPKRQSNTFPFFSDGLARSRTAQEKVAALEQQVLMLTKELKSQKELVIILHKALEAAQQE 346

  Fly   700 ANATSS--------------SNPHQKLANGSQQLQ--------LEHGNGEEDQENLVLDEGENDV 742
            ..|:|:              .:..:::|..:|:::        |.|..|..:|:...|.:....:
Mouse   347 KRASSAYLAATEDRDRLELVRHKVRQIAELNQRVEALEQGRERLAHEAGLREQQVQALQQHVQLL 411

  Fly   743 FDDND-------------FSDISDPGDLFDEPELGQEAEEQEQSNLEEEVFEKQEDEEDQEDHD- 793
            .|.|.             ..|::.|.|..:...|.|: |..|....:.|.:..|....:.|.|.
Mouse   412 MDKNHAKQQVICKLTQKLTEDLAQPADATNGDFLSQQ-ERMEHLKDDMEAYRTQNRFLNSEIHQV 475

  Fly   794 --------QREMPRLSEKLVLEFQNIDNMEPL-----RLQENCFADSETENDLGLGL-------- 837
                    ::|...|::...|:.:|.......     ||||...|::....:|...|
Mouse   476 TKIWRKVAEKEKALLTKCAYLQARNCQVESKYLAGLRRLQEAAGAEAGDFPELLQQLIQEALQWE 540

  Fly   838 ----DSSGNILMLSIKSSPSTSSYETVGNEFLDMAEAKLEEEEPPGQLSKFHSADDVRLDNQDEE 898
                ||.|        .|| .|.|:..|  ||.:.:.::|:.:   .|:|. .|.:||..:....
Mouse   541 AGEADSVG--------LSP-VSEYDDYG--FLTVPDYEMEDLK---LLAKI-QALEVRSHHLLAH 590

  Fly   899 ES-SQP-----ATAVIITEAASLDAL--DDDPTEE--------FTSRKTSLMSPLNEDITVVASL 947
            |: .:|     ||...:|.:|.|..|  ...|.|.        ...|...|.:|        ...
Mouse   591 EAVERPLRDRWATLTELTPSAELKQLLRAGVPREHRPRVWRWLVHRRVRHLQAP--------GCY 647

  Fly   948 DALQEPKSACVSPASSNGGVYSVELLEQFGLNLHRIEKDVQR---CDRNYWYFANENLDKLRNVI 1009
            ..|.....||..||:                  .:||.|:.|   .::::....:...||||.|:
Mouse   648 QELLARGRACEHPAA------------------RQIELDLNRTFPTNKHFTCPTSSFPDKLRRVL 694

  Fly  1010 STYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLI 1074
            ..:.|::..:||.||:..|.|..|::.:||..::.|...::|.::........:.....:.|.|.
Mouse   695 LAFSWQNPTIGYCQGLNRLAAIALLVLEDEESAFWCLVAIVETILPAEYYSKTLTASQVDQRVLQ 759

  Fly  1075 QILDSEMYDLMDSNGDY--THFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLF-L 1136
            .:|..::..|....|.:  ......:.|||:.|...|:.|.:...|:..     :..|..|:| .
Mouse   760 DLLSEKLPRLTAHLGQHRVDLSLITFNWFLVVFADSLISDILLRVWDAF-----LYEGTKVVFRY 819

  Fly  1137 ALALLETYRDII--LSNSMDFTDVIKFFNE 1164
            |||:.:...:.|  |.:|::....::||.:
Mouse   820 ALAIFKYNEEAILQLQDSLEIYQYLRFFTK 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN_SGSM1_like	39..233	CDD:439049
		PH_RUTBC	310..485	CDD:275431
		TBC	947..1124	CDD:214540	38/181 (21%)
Tbc1d2	XP_006538109.1	PH_TBC1D2A	45..146	CDD:269966
		PRK12323	<192..404	CDD:481241	19/121 (16%)
		COG4913	<307..>464	CDD:443941	25/157 (16%)
		TBC	620..832	CDD:214540	49/242 (20%)