DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1695 and TBC1D10C

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_001356427.1	Gene:	TBC1D10C / 374403	HGNCID:	24702	Length:	454	Species:	Homo sapiens

Alignment Length:	175	Identity:	39/175 - (22%)
Similarity:	60/175 - (34%)	Gaps:	51/175 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1005 LRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESL-------SYSCFCKLMERMIENFPSGGA 1062
            |..|:..|.....:.||.|....:.|.||:....|:.       ::.|..::.|..:.     |.
Human   160 LLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEACALPLPQEAFWCLVQICEVYLP-----GY 219

  Fly  1063 MDMHFANMRSLIQILDSEMY-DLMDSNGDYTH----------FYFCYRWFLLDFKRELVYDDVFA 1116
            ...|...:|     ||:|:: .|:.....:.|          ..:...|||..|.|.|.:..|..
Human   220 YGPHMEAVR-----LDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLR 279

  Fly  1117 TWEVIWAAKHIASGHFVLF--------LAL----------ALLET 1143
            .|:..     ::.|..|||        |||          .||||
Human   280 VWDAF-----LSEGARVLFRVGLTLVRLALGTAEQRGACPGLLET 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431
		SRP68-RBD	<648..>713	CDD:304552
		TBC	947..1124	CDD:214540	28/136 (21%)
TBC1D10C	NP_001356427.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58
		TBC	89..302	CDD:214540	32/156 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..454
		Interaction with calcineurin	414..454
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810