DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1695 and Rabgap1

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_001101311.1	Gene:	Rabgap1 / 311911	RGDID:	1304691	Length:	1065	Species:	Rattus norvegicus

Alignment Length:	893	Identity:	168/893 - (18%)
Similarity:	301/893 - (33%)	Gaps:	309/893 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   434 LDPPLWSQRGIGKLFPWPKSVRRHI-------LPSVMEAGGSVTDETPIDYVFRVVSKCQHEEFL 491
            :|||:..|.|:         .|.|:       |.:.:.|..::
  Rat    69 MDPPMDDQPGM---------ERSHLDGEGDGPLSNQLSASSTI---------------------- 102

  Fly   492 ASHPILELGRSSPRRKHLGSCSTTGSSDCSSKSLSIDQSSCETPLIQASQSTSIELVCSTMRRQI 556
              :|:..:|...|... |...|..|.|:.||            |....:...|:
  Rat   103 --NPVPLVGLQKPEMS-LPVKSGQGDSEVSS------------PFTPVADEDSV----------- 141

  Fly   557 ISRAFYGWLAY--CRHLSTVRTHLSGLVNGRIMPDLAAD-EEGLTRGKWLAMHEDGVVTGDLELY 618
                .:..|.|  |..::..|:.:..|   |:|..|.:. :..|.    :.:....|..|.:.|
  Rat   142 ----VFNKLTYLGCASVNAPRSEVEAL---RMMSILRSQCQISLD----VTLSVPNVSEGTVRL- 194

  Fly   619 RLVYFGGVEPELRKEVWPY--------LLGHYDFGSTPEERKKQDETCKHYYETTMSEWL----- 670
                   ::|::..|:..|        :.||   ..|||      ..|..:.|:..:..|
  Rat   195 -------LDPQINTEIANYPIYKILFCVRGH---DGTPE------SDCFAFTESHYNAELFRIHV 243

  Fly   671 ----AVEAIVRQREKEKTALAVAKLSAEQARLAANATSSSNPHQKLANGSQQLQLEHGNG----- 726
                ..||:.|......||.   :.||:|..|:|.| :...|...:...|..|:::..:|
  Rat   244 FRCEIQEAVSRILYSFATAF---RRSAKQTPLSATA-APQTPDSDIFTFSVSLEIKEDDGKGYFS 304

  Fly   727 ----EEDQENLVLDEG-------------ENDVFDDNDFSDISDPGDLFDEPELGQEAEEQEQSN 774
                ::|::...|.:|             ..::..:..|..:..|         |::....:...
  Rat   305 AVPKDKDRQCFKLRQGIDKKIVICVQQTANKELAIERCFGLLLSP---------GKDVRNSDMHL 360

  Fly   775 LEEEVFEKQEDEED---------QEDHDQ---REMPRLSEKLVLEFQNIDNM-----EPLRLQEN 822
            |:.|...|..|.:.         :..|.|   .|.|:  :|::.....:|.:     ||:|.
  Rat   361 LDLESMGKSSDGKSYVITGSWNPKSPHFQVVNEETPK--DKVLFMTTAVDLVITEVQEPVRF--- 420

  Fly   823 CFADSETENDLGLGLDSSGNILMLSIK-SSPST------SSYETVGNEFLDMAEAKLEEEEPPGQ 880
                                :|...:: .||:.      |...|..|.||.:.:.|.:|
  Rat   421 --------------------LLETKVRVCSPNERLFWPFSKRSTTENFFLKLKQIKQKE------ 459

  Fly   881 LSKFHSADD----VRLDNQDEEE--SSQPATAVIITEAASLDALDDDPTEEFTSRKTSLMSPLNE 939
              |.::||.    |.|:::.|.|  .:..:.:|.:.::.|..::...|.|:.......  .||
  Rat   460 --KKNNADTLYEVVCLESESERERRKTTASPSVRLPQSGSQSSMIPSPPEDDEEEDND--EPL-- 518

  Fly   940 DITVVASLDALQEPKSACVSPASSNGGVYSVELLEQFGLNL------------------------ 980
                   |....:....|........|    |||.::.|||
  Rat   519 -------LSGFGDVSKECAEKILETWG----ELLSKWHLNLNVRPKQLSSLVRSGVPEALRGEVW 572

  Fly   981 ----------HRIEK-----------------DVQRCDRNYWYF---ANENLDKLRNVISTYVWE 1015
                      |.:||                 |:.|....:.||   ..:..|.|..:...|...
  Rat   573 QLLAGCHNNDHLVEKYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVY 637

  Fly  1016 HLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLM------ERMIENFPSGGAMDMH--FANMRS 1072
            ..::||.||...|.|.||:...:|. ::|...|:|      |...:||.     |:|  |..:..
  Rat   638 DEEIGYCQGQSFLAAVLLLHMPEEQ-AFSVLVKIMFDYGLRELFKQNFE-----DLHCKFYQLER 696

  Fly  1073 LIQILDSEMYD-LMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLF- 1135
            |:|....::|: .:|.:.: .|.| ..:|||..|..:.....||...:::     :..|..|:|
  Rat   697 LMQEYIPDLYNHFLDISLE-AHMY-ASQWFLTLFTAKFPLYMVFHIIDLL-----LCEGISVIFN 754

  Fly  1136 LALALLETYRDIILSNSMDFTDVIKFFN-EMAERH----NAQSILQLS 1178
            :||.||:|.:|.:|..  ||...:|||. ::.:|:    ||:.:::|:
  Rat   755 VALGLLKTSKDDLLLT--DFEGALKFFRVQLPKRYRSEENAKRLMELA 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431	9/57 (16%)
		SRP68-RBD	<648..>713	CDD:304552	17/73 (23%)
		TBC	947..1124	CDD:214540	49/239 (21%)
Rabgap1	NP_001101311.1	PTB_Rab6GAP	141..269	CDD:269922	30/169 (18%)
		DUF3694	303..433	CDD:403614	22/163 (13%)
		TBC	559..768	CDD:214540	49/221 (22%)
		ERM	790..1016	CDD:395622	3/11 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900