DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1695 and Rabgap1l

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	XP_006250167.1	Gene:	Rabgap1l / 304914	RGDID:	1304620	Length:	1051	Species:	Rattus norvegicus

Alignment Length:	849	Identity:	166/849 - (19%)
Similarity:	290/849 - (34%)	Gaps:	280/849 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   406 RP--PIHFPEGGHL----QAFLSCLETGLLPHGQLDPPLWSQRGIGKLF----------PWPKSV 454
            ||  |..|||...:    ..:|.|::..            |.|..|:..          .:|.:|
  Rat   116 RPSSPSGFPEEDSVLFNKLTYLGCMKVS------------SPRSEGEALRAMATMRASSQYPFAV 168

  Fly   455 RRHILPSVMEAGGSVTDETPIDYVFRVVSKCQHEEFLASHPILELGRSSPRRKHLG----SCSTT 515
            ..:: |:|.|  |||          |::.:..:.| :||.||.::...:  |.|.|    :|...
  Rat   169 TLYV-PNVPE--GSV----------RIIDQSSNVE-IASFPIYKVLFCA--RGHDGTTESNCFAF 217

  Fly   516 GSSDCSSKSLSIDQSSCETPLIQASQSTSIELVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSG 580
            ..|...|:...|...|||.                   ::.:||..|   ::|.........:|.
  Rat   218 TESSHGSEEFQIHVFSCEI-------------------KEAVSRILY---SFCTAFKRSSRQVSD 260

  Fly   581 LVNGRIMPDLAADEEGLTRGKWLAMHEDGVVTGDLELYRLVYFGGVEPELRKEVWPYLLGHYDFG 645
             |...|:|  ..|.:..|....|.:.||.                              |..:|.
  Rat   261 -VKDSIIP--TPDSDVFTFSVSLEVKEDD------------------------------GKGNFS 292

  Fly   646 STPEERKKQDETCKHYYETTMSEWLAVEAIVRQREKEKTALAVAKLSAEQARLAANATSSSNPHQ 710
            ..|::|.      |.|::            ::|..::|..:.|.:||
  Rat   293 PVPKDRD------KFYFK------------IKQGIEKKVVITVQQLS------------------ 321

  Fly   711 KLANGSQQLQLEHGNGEEDQENLVLDEGENDVFDDNDFSDISDPGDLFDEPELGQEAEEQEQSNL 775
                 :::|.:|...|      ::|..|.|....|....|:...|..:|    |:........|.
  Rat   322 -----NKELAIERCFG------MLLSPGRNVKNSDMHLLDMESMGKSYD----GRAYVITGMWNP 371

  Fly   776 EEEVFEKQEDEEDQEDHDQREMPRLSEKLVLEFQNIDNMEPLRLQENCFADSETENDLGLGLDSS 840
            ...:|....:|..:   |:|....::..:|:    .:.:||:|.
  Rat   372 NAPIFLALNEETPK---DKRVYMTVAVDMVV----TEVVEPVRF--------------------- 408

  Fly   841 GNILMLSIKSSPSTSSYETVGNE-FLDMAEAKLEEEEPPGQLSKFHSADDVRLDNQDEEESSQPA 904
              :|...::..|:...:.....: |.:....:|::.|..|..|...:..:| :..|.|.:..:|.
  Rat   409 --LLETVVRVYPANERFWYFSRKTFTETFFMRLKQSEGKGHSSAGDAIYEV-VSLQRESDKEEPV 470

  Fly   905 TAVIITEAASLDALDDDPTEEFTSRKTSLMSPLNEDI--TVVASLDAL---------QEPKSACV 958
            |..  :........:|:..||..:..:|....:::|.  .::.|...|         ..||..
  Rat   471 TPT--SGGGPASPQEDEAEEESDNELSSGTGDVSKDCPEKILYSWGELLGRWHNNLNARPKGL-- 531

  Fly   959 SPASSNGGVYSV------ELL-----EQFGLNLHR------------IEKDVQRCDRNYWYF--- 997
             |.....||...      :||     .|..|:.:|            |.:|:.|....:.||
  Rat   532 -PTLVKSGVPEALRAEVWQLLAGCHDNQAMLDKYRILITKDSAQESVITRDIHRTFPAHDYFKDT 595

  Fly   998 ---ANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIE---- 1055
               ..|:|.|:....|.|   ..|:||.||...|.|.||:...:|    ..||.|:..|.:
  Rat   596 GGDGQESLYKICKAYSVY---DEDIGYCQGQSFLAAVLLLHMPEE----QAFCVLVNIMYKYKLR 653

  Fly  1056 -----NFPSGGAMDMH--FANMRSLIQILDSEMYDLMDSNGDYTHF--------YFCYRWFLLDF 1105
                 ||.     |:|  |..:..|:|   .::.||      |:||        .:..:|||..|
  Rat   654 DLYKNNFE-----DLHCKFYQLEKLMQ---EQLPDL------YSHFCDLNLEAHMYASQWFLTLF 704

  Fly  1106 KRELVYDDVFATWEVIWAAKHIASGHFVLF-LALALLETYRDIILSNSMDFTDVIKFFN-EMAER 1168
            ..:.....||...:::     :..|..::| :|||||:|.::.:|  ..||...:|||. ::.:|
  Rat   705 TAKFPLCMVFHIIDLL-----LCEGLNIIFHVALALLKTSKEDLL--QADFEGALKFFRVQLPKR 762

  Fly  1169 HNAQ 1172
            :.|:
  Rat   763 YRAE 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431	20/94 (21%)
		SRP68-RBD	<648..>713	CDD:304552	9/64 (14%)
		TBC	947..1124	CDD:214540	53/233 (23%)
Rabgap1l	XP_006250167.1	PTB_Rab6GAP	129..257	CDD:269922	33/177 (19%)
		DUF3694	340..421	CDD:289256	17/114 (15%)
		RabGAP-TBC	541..744	CDD:278964	55/228 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900