DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1695 and Tbc1d9

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	XP_006255308.1	Gene:	Tbc1d9 / 304645	RGDID:	1308221	Length:	1262	Species:	Rattus norvegicus

Alignment Length:	795	Identity:	152/795 - (19%)
Similarity:	288/795 - (36%)	Gaps:	213/795 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   488 EEFLASHPILELGRSSP-----RRKHLGSCSTTGSSDC----SSKSLSIDQSSCETP---LIQAS 540
            ||.|.::.:....|::|     |||..|.....|....    .:..:.:|.|:...|   |.|..
  Rat     6 EEVLLANALWITERANPYFILQRRKGHGGDGGGGGGLAGLLVGTLDVVLDSSARVAPYRILYQTP 70

  Fly   541 QSTSI-ELVCSTMRRQIISRAFYGW--------LAYCRHLSTVRTHLSGLVNGRI-----MPDLA 591
            .|... .:.|...|:::...  :.|        |:...:.:.|.|.:.|.:.|.|     :.|:.
  Rat    71 DSLVYWTIACGGSRKEVTEH--WEWLEQNLLQTLSIFENENDVTTFVRGKIQGIIAEYNKINDVK 133

  Fly   592 ADE------EGLTR-GKWLAMHEDGVVTGDLELYRLVYFGGVEPELRKEVWPYL-LGHYDFGSTP 648
            .||      |.:.: .:...|.|:..:   :..|...|:.|..|   ::.|.|| :.|..|.|..
  Rat   134 EDEDTEKFKEAIVKFHRLFGMPEEEKL---VNYYSCSYWKGKVP---RQGWMYLSINHLCFSSFL 192

  Fly   649 EERKKQDETCKHYYETTMSEWLAVEAIVRQREKEKTALA--VAKLSAEQAR----LAANATSSSN 707
            ..|:.:          .:..|:.    :.|.||..|.|.  :.|:|...:.    :..|...:..
  Rat   193 MGREAK----------LVIRWVD----ITQLEKNATLLLPDMIKVSTRSSEHFFSVFLNINETFK 243

  Fly   708 PHQKLANGSQQLQLEHGNGEEDQENLVLDEGENDVFDDNDFSDISDPGDLFDEPELGQEAEEQEQ 772
            ..::|||.:.:..|::...|:|:....|.:              ..|..:   ..|.::.:.:.:
  Rat   244 LMEQLANIAMRQLLDNEGFEQDRSLPKLKK--------------KSPKKV---SALKRDLDARAK 291

  Fly   773 SNLEEEVFEKQEDEEDQEDHDQREMPRLSEKLVLEFQNIDNMEPLRLQEN--CFADSETENDLGL 835
            |.....:|...:||:.....|.        .|...|..:..:..:.:..|  ||...| ||...|
  Rat   292 SERYRALFRLPKDEKLDGHTDC--------TLWTPFNKMHILGQMFVSTNYICFTSKE-ENLCSL 347

  Fly   836 GL--------DSSGNILMLSIKSSPSTSSYETV------GNEFLDMAEAKLEEEEPPGQLSKFHS 886
            .:        :.:.:..:|....|.||.:..|.      ..:||....:...::    ..|:.:|
  Rat   348 IIPLREVTIVEKADSCSVLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQ----TTSRIYS 408

  Fly   887 ADDVRLDNQDEEESSQPATAVIITEAASLDALDDDPTEEF--------TSRKTSL-----MSPLN 938
            ......::.|:|..|:|::.|..:...|..: |.|....|        |:.:|.:     .||
  Rat   409 EFSGSCNSSDDEVYSRPSSLVSSSPQRSTSS-DADGERPFNLNGNSVPTATQTLMTMYRRRSP-- 470

  Fly   939 EDITVVASLDALQE------------------------------PK----------SACVSPASS 963
            |:.....:.:.|:|                              |:          |..::..::
  Rat   471 EEFNPKLAKEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPERMRGELWLLLSGAINEKAT 535

  Fly   964 NGGVYSVELLE----QFGLNLHRIEKDVQRCDRNYWYFANE-NLDKLRNVISTYVWEHLDVGYMQ 1023
            :.|.|. :|:|    ::.|....||:|:.|....:..|.|| .:..||.|::.|.:.:.::||.|
  Rat   536 HPGYYE-DLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAALRRVLTAYAFRNPNIGYCQ 599

  Fly  1024 GMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSN 1088
            .| ::|..:|:::..|..::.....|.|||:.:          :.|.|.:..::|..:::  :..
  Rat   600 AM-NIVTSVLLLYAKEEEAFWLLVALCERMLPD----------YYNTRVVGALVDQGVFE--ELA 651

  Fly  1089 GDYT-HFYFCYR-----------WFL------LDFKRELVYDDVFATWEVIWAAKHIASGHFVLF 1135
            .||. ..|.|.:           |||      :.|:..:|..|.|           ...|..|:|
  Rat   652 RDYVPQLYDCMQDLGVISTISLSWFLTLFLSVMPFESAVVVVDCF-----------FYEGIKVIF 705

  Fly  1136 -LALALLETYRDIIL 1149
             ||||:|:...|.:|
  Rat   706 QLALAVLDANVDKLL 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431
		SRP68-RBD	<648..>713	CDD:304552	10/70 (14%)
		TBC	947..1124	CDD:214540	45/239 (19%)
Tbc1d9	XP_006255308.1	PH-GRAM1_TCB1D9_TCB1D9B	157..255	CDD:275420	23/117 (20%)
		PH-GRAM2_TCB1D9_TCB1D9B	304..399	CDD:270161	19/103 (18%)
		TBC	510..720	CDD:214540	52/234 (22%)
		EFh	<891..921	CDD:298682
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900