DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1695 and Rabgap1l

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	XP_006496938.1	Gene:	Rabgap1l / 29809	MGIID:	1352507	Length:	1051	Species:	Mus musculus

Alignment Length:	848	Identity:	162/848 - (19%)
Similarity:	296/848 - (34%)	Gaps:	278/848 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   406 RP--PIHFPEGGHL----QAFLSCLETGLLPHGQLDPPLWSQRGIGKLFPWPKSVRRHILPSVME 464
            ||  |..|||...:    ..:|.|::.. .|..::: .|.:...:.....:|.:|..:: |:|.|
Mouse   116 RPSSPSRFPEEDSVLFNKLTYLGCMKVS-SPRSEVE-ALRAMATMRASSQYPFAVTLYV-PNVPE 177

  Fly   465 AGGSVTDETPIDYVFRVVSKCQHEEFLASHPILELGRSSPRRKHLGSCSTTGSSDC--------S 521
              |||          |::.:..:.| :||.||.::...:  |.|.|    |..|:|        .
Mouse   178 --GSV----------RIIDQSSNVE-IASFPIYKVLFCA--RGHDG----TAESNCFAFTESSHG 223

  Fly   522 SKSLSIDQSSCETPLIQASQSTSIELVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGLVNGRI 586
            |:...|...|||.                   ::.:||..|   ::|.........:|. |...:
Mouse   224 SEEFQIHVFSCEI-------------------KEAVSRILY---SFCTAFKRSSRQVSD-VKDSV 265

  Fly   587 MPDLAADEEGLTRGKWLAMHEDGVVTGDLELYRLVYFGGVEPELRKEVWPYLLGHYDFGSTPEER 651
            :|  ..|.:..|....|.:.||.                              |..:|...|::|
Mouse   266 IP--TPDSDVFTFSVSLEVKEDD------------------------------GKGNFSPVPKDR 298

  Fly   652 KKQDETCKHYYETTMSEWLAVEAIVRQREKEKTALAVAKLSAEQARLAANATSSSNPHQKLANGS 716
            .      |.|::            ::|..::|..:.|.:||                       :
Mouse   299 D------KFYFK------------IKQGIEKKVVITVQQLS-----------------------N 322

  Fly   717 QQLQLEHGNGEEDQENLVLDEGENDVFDDNDFSDISDPGDLFDEPELGQEAEEQEQSNLEEEVFE 781
            ::|.:|...|      ::|..|.|....|....|:...|..:|    |:........|....:|.
Mouse   323 KELAIERCFG------MLLSPGRNVKNSDMHLLDMESMGKSYD----GRAYVITGMWNPNAPIFL 377

  Fly   782 KQEDEEDQEDHDQREMPRLSEKLVLEFQNIDNMEPLRLQENCFADSETENDLGLGLDSSGNILML 846
            ...:|..:   |:|....::..:|:    .:.:||:|.                       :|..
Mouse   378 ALNEETPK---DKRVYMTVAVDMVV----TEVVEPVRF-----------------------LLET 412

  Fly   847 SIKSSPSTSSYETVGNE-FLDMAEAKLEEEEPPGQLSKFHSADD-----VRLDNQ-DEEESSQPA 904
            .::..|:...:.....: |.:....:|::.|..|.    .||.|     |.|..: |:||...|.
Mouse   413 VVRVYPANERFWYFSRKTFTETFFMRLKQSEGKGH----SSAGDAIYEVVSLQRESDKEEPITPT 473

  Fly   905 TAVIITEAASLDALDDDPTEEFTSRKTSLMSPLNED---------------------------IT 942
            :|     ...:...:|:..||..:..:|....:::|                           .|
Mouse   474 SA-----GGPMSPQEDEAEEESDNELSSGTGDVSKDCPEKILYSWGELLGRWHNNLGGRPKGLFT 533

  Fly   943 VVAS--LDALQEPKSACVSPASSNGGVYSVELLEQFGLNLHR-------IEKDVQRCDRNYWYF- 997
            :|.|  .:||:......::....|     .|:|:::.:.:.:       |.:|:.|....:.||
Mouse   534 LVKSGVPEALRAEVWQLLAGCHDN-----QEMLDKYRILITKDSAQESVITRDIHRTFPAHDYFK 593

  Fly   998 --ANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFC---------KLME 1051
              ..:..:.|..:...|.....|:||.||...|.|.||:...:|    ..||         ||.:
Mouse   594 DTGGDGQESLYKICKAYSVFDEDIGYCQGQSFLAAVLLLHMPEE----QAFCVLVTIMYGYKLRD 654

  Fly  1052 RMIENFPSGGAMDMH--FANMRSLIQILDSEMYDLMDSNGDYTHF--------YFCYRWFLLDFK 1106
            ....||.     |:|  |..:..|:|   .::.||      |:||        .:..:|||..|.
Mouse   655 LYRNNFE-----DLHCKFYQLEKLMQ---EQLPDL------YSHFCDLNLEAHMYASQWFLTLFT 705

  Fly  1107 RELVYDDVFATWEVIWAAKHIASGHFVLF-LALALLETYRDIILSNSMDFTDVIKFFN-EMAERH 1169
            .:.....||...:::     :..|..::| :|||||:|.::.:|  ..||...:|||. ::.:|:
Mouse   706 AKFPLCMVFHIIDLL-----LCEGLNIIFHVALALLKTSKEDLL--QADFEGALKFFRVQLPKRY 763

  Fly  1170 NAQ 1172
            .|:
Mouse   764 RAE 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431	19/84 (23%)
		SRP68-RBD	<648..>713	CDD:304552	9/64 (14%)
		TBC	947..1124	CDD:214540	44/205 (21%)
Rabgap1l	XP_006496938.1	PTB_Rab6GAP	129..257	CDD:269922	33/171 (19%)
		DUF3694	290..421	CDD:372133	32/211 (15%)
		RabGAP-TBC	541..744	CDD:366170	52/230 (23%)
		Smc	<814..>1019	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900