DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1695 and TBC1D10B

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_056342.3	Gene:	TBC1D10B / 26000	HGNCID:	24510	Length:	808	Species:	Homo sapiens

Alignment Length:	381	Identity:	84/381 - (22%)
Similarity:	121/381 - (31%)	Gaps:	126/381 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   827 SETENDLG----LGLDSSGNILMLSIKSSPSTSSYETVGNEFLDMAEAKLEEEEPPGQLSKFHSA 887
            :|...|||    ||...||     ....:|.|.||       ||.....      .|.|...  |
Human   240 AENSQDLGSTSSLGPGISG-----PRGQAPDTLSY-------LDSVSLM------SGTLESL--A 284

  Fly   888 DDVRLDNQDEE------------------------ESSQPATAVIITEAASLDALDDDPTEEFTS 928
            |||.....|.|                        |||.|.......|...||...:  .:::.|
Human   285 DDVSSMGSDSEINGLALRKTDKYGFLGGSQYSGSLESSIPVDVARQRELKWLDMFSN--WDKWLS 347

  Fly   929 RKTSLMSPLNEDITVVASLDALQEPKSACVS--PASSNGGVY-----SVELLEQFGLN------- 979
            |:                   .|:.|..|..  |:|.....:     |.|||||   |
Human   348 RR-------------------FQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQ---NPGKFEEL 390

  Fly   980 ---------LHRIEKDVQRCDRNYWYFA---NENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPL 1032
                     |..||||:.|....:..||   ......|..::..|.....|.||.|....:.|.|
Human   391 ERAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVL 455

  Fly  1033 LVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSEM-YDLMDSNGDYTHFY- 1095
            |:....|. ::.|..::.::.:..:.|.|.         ..|| ||.|: :.|:.......|.:
Human   456 LMHMPAEQ-AFWCLVQICDKYLPGYYSAGL---------EAIQ-LDGEIFFALLRRASPLAHRHL 509

  Fly  1096 ---------FCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLF-LALALL 1141
                     :...||:..|.|.|.:..|...|::.:     ..|..::| :||.||
Human   510 RRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFF-----CEGVKIIFRVALVLL 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431
		SRP68-RBD	<648..>713	CDD:304552
		TBC	947..1124	CDD:214540	47/213 (22%)
TBC1D10B	NP_056342.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..225
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..264		8/28 (29%)
		TBC	357..562	CDD:214540	51/223 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	629..808
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900