Protein Alignment CG1695 and Tbc1d8b

DIOPT Version :10

• Sequence 1: NP_728346.2
• Gene: CG1695 / 33046
• FlyBaseID: FBgn0031116
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: NP_001074968.1
• Gene: Tbc1d8b / 245638
• MGIID: 1918101
• Length: 1114
• Species: Mus musculus
• Alignment Length: 753
• Identity: 155/753 - (20%)
• Similarity: 273/753 - (36%)
• Gaps: 222/753 - (29%)

  Fly   533 ETPLIQASQSTSIELVCSTMRRQIISRAFYGWLA--YCRHLSTVRTH--LSGLVNGRIMPDLAAD 593
            :||    .....:.:.|...|.:|...  :.||.  ..:.||...::  ::..|.|:|. .|.|:
Mouse    68 QTP----DSQVYLSIACGANREEITKH--WDWLEQNIMKTLSVFDSNEDITNFVQGKIR-GLIAE 125

  Fly   594 EEGLTRGKWLAMHEDGVVTGDLELYR--LVYFG---GVEPELRKEV----------------WPY 637
            |     ||.....||     |.|.:|  |:.|.   |: ||..|.|                |.|
Mouse   126 E-----GKQSFAKED-----DPEKFREALLKFEKSFGL-PEQEKLVTYYSCSYWRGRVPCQGWLY 179

  Fly   638 L----LGHYDF--GSTPEERKKQDETCKHYYETTMSEWLAVEAIVRQREKEKTALAVAKLSAEQA 696
            |    |..|.|  ||   |.|            .:..|.|:..:      |||:..:...|....
Mouse   180 LSTNFLSFYSFLLGS---EIK------------LIISWDAISKL------EKTSTVILTESIHVC 223

  Fly   697 RLAANATSSSNPHQKLANGSQQLQLEHGNGEEDQENLVLDEGENDVFDDNDFSDISDPGDLFDEP 761
            ....|...|...|   .|.:..|.       |...|..:..    :||...|.  :||  :.|:|
Mouse   224 SQGENHYFSMFLH---INETYLLM-------EQLANYAIKR----LFDKETFD--NDP--VLDDP 270

  Fly   762 -ELGQEA-EEQEQSNLEEEVFEKQEDEEDQEDHDQREMPRLSEKLVLEFQNIDNMEPLRLQEN-- 822
             ::.:.. |.:..|...:..|...::|..:|.|:.        .|.:.|.:..:...:.:.||
Mouse   271 LQITKRGLEYRAHSEQFKAFFRLPKEETLKEVHEC--------FLWVPFSHFSSHGKMCISENYI 327

  Fly   823 CFADSE---------TENDLGLG-LDSSGNILMLSIKSSPSTSSYETVGNEFLDMAEAKLE---- 873
            |||..:         ....|.:. .|.|...:::|||...:....|....|.| :|:.:|:
Mouse   328 CFASQDGNLCSVIIPLREVLAIDKTDDSNRSVIISIKGKTAFRFSELKDFEQL-VAKLRLKCRAA 391

  Fly   874 -----------------------EEEP---PGQLSK----------FHSADDVRLDNQD----EE 898
                                   ||:|   |.:.||          ||..:   |:|.|    :|
Mouse   392 STQDDVSTEVAVSSDSTGPSENFEEQPLTCPKECSKTVNTEALMTVFHPQN---LENLDSKMLKE 453

  Fly   899 ESSQPATAVIITEAASLDALDDDPTEEFTSRKTSLMSPLNEDITVVASLDALQEPK----SACVS 959
            :..:.:..::.:|...       ....|.::||       .|:.|....:.|:...    |..|:
Mouse   454 KMKEQSWNILFSECGR-------GVSMFRTKKT-------RDLVVRGIPETLRGELWMLFSGAVN 504

  Fly   960 PASSNGGVYSVELLEQ----FGLNLHRIEKDVQRCDRNYWYFANE-NLDKLRNVISTYVWEHLDV 1019
            ..::|.|.|: |::||    ..|....||:|::|....:..|.:: .:..||.|::.|.:.:..:
Mouse   505 DMATNPGYYA-EVVEQSLGTSNLATEEIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNPKI 568

  Fly  1020 GYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSEMYD- 1083
            ||.|.| :::..:|:::..|..::.....:.|||:.:          :.|.|.:..::|..:::
Mouse   569 GYCQAM-NILTSVLLLYAKEEEAFWLLVAVCERMLPD----------YFNRRIIGALVDQAVFEE 622

  Fly  1084 --------LMDSNGDYTHF-YFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHF------V 1133
                    |.|...|.|.| .....|||          .:|.:...|.:|.::....|      :
Mouse   623 LIRDHLPQLTDHMTDMTFFSSVSLSWFL----------TLFISVLPIESAVNVVDCFFYDGIKAI 677

  Fly  1134 LFLALALLETYRDIILSNSMD---FTDVIKFFNEMAER 1168
            |.|.||:|:...|.:|:...|   .|.:.:||:.:..:
Mouse   678 LQLGLAILDYNLDKLLTCKDDAEAVTALNRFFDNVINK 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN_SGSM1_like	39..233	CDD:439049
		PH_RUTBC	310..485	CDD:275431
		TBC	947..1124	CDD:214540	41/195 (21%)
Tbc1d8b	NP_001074968.1	PH-GRAM1_TBC1D8B	156..254	CDD:275419	25/128 (20%)
		PH-GRAM2_TBC1D8B	296..388	CDD:270159	21/100 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	399..420		3/20 (15%)
		TBC	485..693	CDD:214540	49/229 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	938..957
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1032..1061