DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1695 and TBC1D30

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	XP_024304669.1	Gene:	TBC1D30 / 23329	HGNCID:	29164	Length:	944	Species:	Homo sapiens

Alignment Length:	243	Identity:	50/243 - (20%)
Similarity:	90/243 - (37%)	Gaps:	64/243 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   917 ALDDDPTEEFTSRKTSLMSPLNEDITVVASLDALQEPKSACVSPASSNGGVYSVELLEQFGLNLH 981
            |:|.|.|..||..:.|                          :|...:.|:
Human   271 AIDWDKTMRFTFNERS--------------------------NPDDDSMGI-------------- 295

  Fly   982 RIEKDVQR--CDRNYWYFANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFD-DESLSY 1043
            :|.||:.|  |.......|.::...|:.|:..|...:..|||.||...|.|.:|.:.: :|..:.
Human   296 QIVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDAL 360

  Fly  1044 SCFCKLMERMI-ENFPSGG--AMDMHFANMRSLIQILDSEMYDLMD---------SNGDY----T 1092
            .....|::::: |::....  |:.:..|..|.|:::...|:...:|         |.|.|    |
Human   361 KIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYEPPLT 425

  Fly  1093 HFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLFLALAL 1140
            : .|..:|||..|...|....|...|:.::    ......:|.::||:
Human   426 N-VFTMQWFLTLFATCLPNQTVLKIWDSVF----FEGSEIILRVSLAI 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431
		SRP68-RBD	<648..>713	CDD:304552
		TBC	947..1124	CDD:214540	40/195 (21%)
TBC1D30	XP_024304669.1	RabGAP-TBC	296..476	CDD:306939	41/178 (23%)
TBC1D30	XP_024304669.1	DUF4682	637..785	CDD:318030
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900