Protein Alignment CG1695 and Tbc1d17

DIOPT Version :10

• Sequence 1: NP_728346.2
• Gene: CG1695 / 33046
• FlyBaseID: FBgn0031116
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: NP_001036120.1
• Gene: Tbc1d17 / 233204
• MGIID: 2449973
• Length: 645
• Species: Mus musculus
• Alignment Length: 447
• Identity: 116/447 - (25%)
• Similarity: 181/447 - (40%)
• Gaps: 96/447 - (21%)

  Fly   800 LSEKLVLEFQNIDNMEPLRLQENCFADSETENDLGLGLDSSGNILMLSIKSSPST--SSYETVGN 862
            ||..|:|.....|:...|...::..|.|::.:.|.|....|.|::...::...||  ||:..|.|
Mouse   167 LSRYLLLASSPQDSRLYLVFPQDPSALSDSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTN 231

  Fly   863 EFLDMAE-----------AKLEEEEP-PGQLSKFHSADDVRLDNQDEEESSQPATAVIITEAASL 915
            .|....:           ..|.::|| ||    |.....|.|..:...|.:.|.|
Mouse   232 FFRGALQPHPEGASSPNLPPLPDDEPEPG----FEVISCVELGQRPTVERAPPVT---------- 282

  Fly   916 DALDDDPTEEFTSRKTSLMSPLNEDITVVASLDALQEPKSACVSPASSNG----------GVYSV 970
                   .||:           |..:.....|..:.|.|:...|...|.|          |..|.
Mouse   283 -------EEEW-----------NRYVGPEGRLQNVPELKNRIFSGGLSPGLRREAWKFLLGYLSW 329

  Fly   971 ELL-------------EQFGLNLH--------------------RIEKDVQRCDR-NYWYFANEN 1001
            |..             |.|.:.|.                    .||:||.|.|| |.:|...||
Mouse   330 ESSAEEHKAHVRKKTDEYFRMKLQWKSVSAEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPEN 394

  Fly  1002 --LDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENF-PSGGAM 1063
              |..|.:::.||...|.|:||:|||.||::|:|.:..:|..::.|||..||.:..|| .|...|
Mouse   395 PGLSLLHDILLTYCMYHFDLGYVQGMSDLLSPILFVVQNEVDAFWCFCGFMELVHGNFEESQETM 459

  Fly  1064 DMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIA 1128
            ......:..|:::||..:.|.:||. |.....||:||.|:.||||..:.||...|||:|..  :.
Mouse   460 KRQLGQLLLLLRVLDQPLCDFLDSQ-DSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTG--LP 521

  Fly  1129 SGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSILQLSRSLVLQL 1185
            ..:..|.:|.|:|:..||.::.:.....:::|..||:..:.:.:.:|..:.:|..||
Mouse   522 GPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEALYRQL 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN_SGSM1_like	39..233	CDD:439049
		PH_RUTBC	310..485	CDD:275431
		TBC	947..1124	CDD:214540	70/223 (31%)
Tbc1d17	NP_001036120.1	PH_RBD	7..204	CDD:432305	10/36 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	57..85
		Required for interaction with OPTN. /evidence=ECO:0000250	217..309		24/123 (20%)
		TBC	307..542	CDD:214540	73/237 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	596..645