DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1695 and TBC1D12

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_056003.1	Gene:	TBC1D12 / 23232	HGNCID:	29082	Length:	775	Species:	Homo sapiens

Alignment Length:	458	Identity:	94/458 - (20%)
Similarity:	168/458 - (36%)	Gaps:	104/458 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   772 QSNLEEEVFEKQEDEEDQEDHDQREMPRLSEKLVLEFQNIDNMEPLRLQENCFADSETENDLGLG 836
            :.||::.....|::.|.:.....:..|:.|.:...||      |||
Human   353 RENLQKTSKIIQQEYEARTGRTCKPPPQSSRRKNFEF------EPL------------------- 392

  Fly   837 LDSSGNILMLSIKSS--PSTSSYETVGN--EFLDM-AEAKLEEEEPPGQLSKFHSADDVRLDNQD 896
               |...|:|..:.|  |:.|..|.:.:  |:.:| ||||..|      :.:.|....:..:...
Human   393 ---STTALILEDRPSNLPAKSVEEALRHRQEYDEMVAEAKKRE------IKEAHKRKRIMKERFK 448

  Fly   897 EEESSQPATAVIITEAASLDALDDDPTEEFTSRKTSL----MSP----------LNEDITVVASL 947
            :||:...|..:.|.|     .|.:......|.|...|    :.|          :..::.:...|
Human   449 QEENIASAMVIWINE-----ILPNWEVMRSTRRVRELWWQGLPPSVRGKVWSLAVGNELNITPEL 508

  Fly   948 ------DALQEPKSACVSPASSNGGVYSVELLEQFGLNLHRIEKDVQRCDRNYWYF--ANENLDK 1004
                  .|.:..||  .|..||......|.:.:: ..:|..|:.|:.|...:.:.|  .....|.
Human   509 YEIFLSRAKERWKS--FSETSSENDTEGVSVADR-EASLELIKLDISRTFPSLYIFQKGGPYHDV 570

  Fly  1005 LRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMER-------------MIEN 1056
            |.:::..|.....||||:||| ..:|.:|::..:|:.::..|..|:.:             |::.
Human   571 LHSILGAYTCYRPDVGYVQGM-SFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKY 634

  Fly  1057 FPSGGAMDMHF-ANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEV 1120
            |   ...::.| .|:..|  .|..:.|.|       |...:...|....:.:.|..|.....|:|
Human   635 F---ATFEVFFEENLSKL--FLHFKSYSL-------TPDIYLIDWIFTLYSKSLPLDLACRVWDV 687

  Fly  1121 IWAAKHIASGHFVLF-LALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSILQLSRSLVLQ 1184
            .     ...|...|| ..|.:|..|.||:|  .|||..:.:|..::.|...::.:.....::.:|
Human   688 F-----CRDGEEFLFRTGLGILRLYEDILL--QMDFIHIAQFLTKLPEDITSEKLFSCIAAIQMQ 745

  Fly  1185 LQT 1187
            ..|
Human   746 NST 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431
		SRP68-RBD	<648..>713	CDD:304552
		TBC	947..1124	CDD:214540	42/198 (21%)
TBC1D12	NP_056003.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..66
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..312
		TBC	481..712	CDD:214540	51/251 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900