Protein Alignment CG1695 and TBC1D9

DIOPT Version :10

• Sequence 1: NP_728346.2
• Gene: CG1695 / 33046
• FlyBaseID: FBgn0031116
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: NP_055945.2
• Gene: TBC1D9 / 23158
• HGNCID: 21710
• Length: 1266
• Species: Homo sapiens
• Alignment Length: 815
• Identity: 161/815 - (19%)
• Similarity: 295/815 - (36%)
• Gaps: 249/815 - (30%)

  Fly   488 EEFLASHPILELGRSSP-----RRK-HLGSCSTTGSSD---CSSKSLSIDQSSCETP---LIQAS 540
            ||.|.::.:....|::|     ||| |.|.....|...   ..:..:.:|.|:...|   |.|..
Human     6 EEVLLANALWITERANPYFILQRRKGHAGDGGGGGGLAGLLVGTLDVVLDSSARVAPYRILYQTP 70

  Fly   541 QSTSI-ELVCSTMRRQIISRAFYGW--------LAYCRHLSTVRTHLSGLVNGRI-----MPDLA 591
            .|... .:.|...|::|...  :.|        |:...:.:.:.|.:.|.:.|.|     :.|:.
Human    71 DSLVYWTIACGGSRKEITEH--WEWLEQNLLQTLSIFENENDITTFVRGKIQGIIAEYNKINDVK 133

  Fly   592 ADE------EGLTR-GKWLAMHEDGVVTGDLELYRLVYFGGVEPELRKEVWPYL-LGHYDFGSTP 648
            .|:      |.:.: .:...|.|:..:   :..|...|:.|..|   ::.|.|| :.|..|.|..
Human   134 EDDDTEKFKEAIVKFHRLFGMPEEEKL---VNYYSCSYWKGKVP---RQGWMYLSINHLCFYSFL 192

  Fly   649 EERKKQDETCKHYYETTMSEWLAVEAIVRQREKEKTALA--VAKLSAEQAR----LAANATSSSN 707
            ..|:.:          .:..|:.    :.|.||..|.|.  |.|:|...:.    :..|...:..
Human   193 MGREAK----------LVIRWVD----ITQLEKNATLLLPDVIKVSTRSSEHFFSVFLNINETFK 243

  Fly   708 PHQKLANGSQQLQLEHGNGEEDQENLVLDEGENDVFDDNDFSDISDPGDLFDEPE----LGQEAE 768
            ..::|||.:.:..|::...|:|:                     |.|......|:    |.::.:
Human   244 LMEQLANIAMRQLLDNEGFEQDR---------------------SLPKLKRKSPKKVSALKRDLD 287

  Fly   769 EQEQSNLEEEVFEKQEDEEDQEDHDQREMPRLSEKLVLEFQNIDNMEPLRLQEN--CFADSETEN 831
            .:.:|.....:|...:||:.....|.        .|...|..:..:..:.:..|  ||...| ||
Human   288 ARAKSERYRALFRLPKDEKLDGHTDC--------TLWTPFNKMHILGQMFVSTNYICFTSKE-EN 343

  Fly   832 DLGLGL-----------DSSGNILMLSIKSSP---STSSYETV--------------GNEFLDMA 868
            ...|.:           |||      |:..||   ||.:..|.              .::||...
Human   344 LCSLIIPLREVTIVEKADSS------SVLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQT 402

  Fly   869 EAKL-EEEEPPGQLSKFHSADDVRLDNQDEEESSQPATAVIITEAASLDALDDDPTEEF------ 926
            .:|: .::|..|   .::|:||        |..|:|::.|..:...|..: |.|...:|
Human   403 TSKIYSDKEFAG---SYNSSDD--------EVYSRPSSLVSSSPQRSTSS-DADGERQFNLNGNS 455

  Fly   927 --TSRKTSL-----MSPLNEDITVVASLDALQE------------------------------PK 954
              |:.:|.:     .||  |:.....:.:.|:|                              |:
Human   456 VPTATQTLMTMYRRRSP--EEFNPKLAKEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPE 518

  Fly   955 ----------SACVSPASSNGGVYSVELLE----QFGLNLHRIEKDVQRCDRNYWYFANE-NLDK 1004
                      |..::..:::.|.|. :|:|    ::.|....||:|:.|....:..|.|| .:..
Human   519 SMRGELWLLLSGAINEKATHPGYYE-DLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAA 582

  Fly  1005 LRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFAN 1069
            ||.|::.|.:.:.::||.|.| ::|..:|:::..|..::.....|.|||:.:          :.|
Human   583 LRRVLTAYAFRNPNIGYCQAM-NIVTSVLLLYAKEEEAFWLLVALCERMLPD----------YYN 636

  Fly  1070 MRSLIQILDSEMYDLMDSNGDYT-HFYFCYR-----------WFL------LDFKRELVYDDVFA 1116
            .|.:..::|..:::  :...||. ..|.|.:           |||      :.|:..:|..|.|
Human   637 TRVVGALVDQGVFE--ELARDYVPQLYDCMQDLGVISTISLSWFLTLFLSVMPFESAVVVVDCF- 698

  Fly  1117 TWEVIWAAKHIASGHFVLF-LALALLETYRDIILS 1150
                      ...|..|:| ||||:|:...|.:|:
Human   699 ----------FYEGIKVIFQLALAVLDANVDKLLN 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN_SGSM1_like	39..233	CDD:439049
		PH_RUTBC	310..485	CDD:275431
		TBC	947..1124	CDD:214540	45/239 (19%)
TBC1D9	NP_055945.2	PH-GRAM1_TCB1D9_TCB1D9B	157..255	CDD:275420	24/117 (21%)
		PH-GRAM2_TCB1D9_TCB1D9B	304..399	CDD:270161	21/109 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..456		11/49 (22%)
		TBC	512..722	CDD:214540	52/234 (22%)
		EFh	<893..923	CDD:415501
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1075..1095
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1132..1164