Protein Alignment CG1695 and tbc-16

DIOPT Version :10

• Sequence 1: NP_728346.2
• Gene: CG1695 / 33046
• FlyBaseID: FBgn0031116
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: NP_508988.3
• Gene: tbc-16 / 180856
• WormBaseID: WBGene00018639
• Length: 725
• Species: Caenorhabditis elegans
• Alignment Length: 666
• Identity: 138/666 - (20%)
• Similarity: 253/666 - (37%)
• Gaps: 154/666 - (23%)

  Fly   583 NGRIMPDLAADEEGLTRGKWLAMHEDGVVTGDLELYRLVYFGGVEPELRKEVWPYLLGHYDFG-S 646
            ||:.||...|||..::    |...|:..|:.|:::                        .:.| :
 Worm   104 NGQAMPAKPADEVKVS----LLSDEESSVSLDIQI------------------------EECGTA 140

  Fly   647 TPEERKKQDETCKHYYETTMSEWLAVEAIVRQREKEKTALAVAKLSAEQARLAANATSSSNPHQK 711
            .|.::.|:..|...|.:             ::......||.|..::.             .||..
 Worm   141 VPVKQVKRPTTLVPYGQ-------------QEDHSFNDALGVPSINV-------------IPHTP 179

  Fly   712 LANGSQQLQLEHGNGEEDQ-ENLVLDEGENDVFDDNDFSDISDPGDLFDEPELGQEAEEQEQSNL 775
            :.:.:.:::.|:...|.|: ....|.....|...|.:.|...|..|..::|:.|...|:..:|.
 Worm   180 IKHENNEIRTENAKDESDKMSQSSLSTSCADEMSDKELSSSEDGDDDCEKPDPGVGLEKILEST- 243

  Fly   776 EEEVFEKQEDE---------EDQEDHDQREMPRLSEKLV----LEFQNIDNMEPLRLQENCFADS 827
              ::|:|..::         .|.:.:|..|..|..:|..    |...|:..|..:|:   .::::
 Worm   244 --QMFDKTPEQFALEHDLMLTDTKSNDSEEQSRGRKKAAGTTSLFSVNLGKMRSMRV---FYSNT 303

  Fly   828 ETENDLGLGLDSSGNILMLSIKSSPSTSSYETVGNEFLDMAEAKLEEEEPPGQLSK----FHSAD 888
            |.         :||.:::.::.|......:.                   .|.|.|    |....
 Worm   304 EC---------TSGQLVIATLDSHYKILHFH-------------------HGGLDKLAYIFEQWS 340

  Fly   889 DVRLDNQDEEESSQPATAVIITEAASLDALDDDPTEEFTSRKT--SLMSPLNEDITVV------- 944
            .::..:..|...|..|...:|....::..::.||.|....:.|  :..|..|:...::
 Worm   341 SIKARSVQEGSPSAIADKQLIICQPAVTKVEKDPEEGLFEKITLNTWRSYENKSGVIIDSGTVRK 405

  Fly   945 ----ASLDALQEPK--------SACVSPASSNGGVYSVELLEQFGLNLHR--------------- 982
                ||:|.....|        ....|.|.....:.:...||...:...|
 Worm   406 HIFFASMDVEMREKVWPFLLRVYPWESSADQRENIKNDLFLEYQNIRKRRYRVTENAQARWISIE 470

  Fly   983 --IEKDVQRCDRNYWYFA---NENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLS 1042
              |.|||.|.||...:||   |.|.:.::|::..|...:.|:.|:|||.||:||||....||..|
 Worm   471 NSIVKDVVRTDRKNPFFAGDNNPNSEIMKNILLNYAVMYPDINYIQGMSDLLAPLLSTLKDEVDS 535

  Fly  1043 YSCFCKLMERMI-ENFPSG--GAMDMHFANMRSLIQILDSEMYD-LMDSNGDYTHFYFCYRWFLL 1103
            |.||...|::.: .:.|.|  ..|:.:...:|:::::...:.|: |.....|.....|.:||.||
 Worm   536 YFCFKNFMQQTVFSSTPQGNENLMETNLTYLRNMLRMFVPDFYEHLEKQRPDAMQLMFVHRWILL 600

  Fly  1104 DFKRELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAER 1168
            .||||...:.....||..||  |..:.:|.||:.:|::..|...:|:..:...:::.||..:|..
 Worm   601 CFKREFPENYALHIWECCWA--HYRTNYFHLFVCVAIVSIYGKDVLTQDLPHDEILLFFASLANH 663

  Fly  1169 HNAQSILQLSRSLVLQ 1184
            .:|..:||.:|.|:.:
 Worm   664 MDATLVLQKARGLLFE 679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN_SGSM1_like	39..233	CDD:439049
		PH_RUTBC	310..485	CDD:275431
		TBC	947..1124	CDD:214540	57/208 (27%)
tbc-16	NP_508988.3	PH_RBD	32..>112	CDD:432305	4/7 (57%)
		TBC	415..644	CDD:214540	63/230 (27%)