DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1695 and TBC1D21

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	XP_006720472.1	Gene:	TBC1D21 / 161514	HGNCID:	28536	Length:	399	Species:	Homo sapiens

Alignment Length:	275	Identity:	64/275 - (23%)
Similarity:	112/275 - (40%)	Gaps:	69/275 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   925 EFTSRKTSLMSPLNEDITVVASLDALQEP--KSAC-----VSPASSNGGVYSVELLEQFGLNLHR 982
            :|.:...|..|..:|.:||    |:::..  |:.|     :.|           |||    ||||
Human    68 KFLTGYFSWQSSQDERLTV----DSMRRKNYKALCQMYEKIQP-----------LLE----NLHR 113

  Fly   983 --------IEKDVQRC-DRNYWYFANENLDKLR---NVISTYVWEHLDVGYMQGMCDLVA--PLL 1033
                    |.:|:|:. |::  ...|..:||.|   .::.:||. :....|.||..:::.  .|:
Human   114 NFTETRNNIARDIQKIYDKD--PLGNVLIDKKRLEKILLLSYVC-NTQAEYQQGFHEMMMLFQLM 175

  Fly  1034 VIFDDESL----------SYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSN 1088
            |..|.|:.          .:||        :.|......:||    :.:||..||....:.:...
Human   176 VEHDHETFWLFQFFLQKTEHSC--------VINIGVAKNLDM----LSTLITFLDPVFAEHLKGK 228

  Fly  1089 GDYTHFYFCYRWFLLDFKREL-VYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNS 1152
            |... ....:.||...|:|.. .:|||:..|||:...|  ...:|.:.:|.::|:..|:.:|..|
Human   229 GAGA-VQSLFPWFCFCFQRAFKSFDDVWRLWEVLLTGK--PCRNFQVLVAYSMLQMVREQVLQES 290

  Fly  1153 MDFTDVIKFFNEMAE 1167
            |...|::...|.:.:
Human   291 MGGDDILLACNNLID 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431
		SRP68-RBD	<648..>713	CDD:304552
		TBC	947..1124	CDD:214540	48/208 (23%)
TBC1D21	XP_006720472.1	TBC	62..287	CDD:214540	59/255 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810