Protein Alignment CG1695 and SGSM1

DIOPT Version :10

• Sequence 1: NP_728346.2
• Gene: CG1695 / 33046
• FlyBaseID: FBgn0031116
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: NP_001035037.1
• Gene: SGSM1 / 129049
• HGNCID: 29410
• Length: 1148
• Species: Homo sapiens
• Alignment Length: 1278
• Identity: 574/1278 - (44%)
• Similarity: 736/1278 - (57%)
• Gaps: 245/1278 - (19%)

  Fly    25 AETELKERLIASVKKEVKQLMEEAVTKKYVHEESSSVTSLCGAVEACLSHGLRRRALGLFKTSST 89
            ||.|.::||:.:|||||||:||||||:|:|||:||.:.|.|.|||||:.|||||||.|..:::..
Human     6 AEAETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFLRSNKI 70

  Fly    90 TALIQKIAKICPEADYVSRRLLELELAQES--HAVSGKRSSCSSDSIIK-PKLLSKGSGSSNSVT 151
            .||..|:.|..|.|:.:||::.:||...||  :.:.|.:     :::.| |||.:
Human    71 AALFMKVGKNFPPAEDLSRKVQDLEQLIESARNQIQGLQ-----ENVRKLPKLPN---------- 120

  Fly   152 TINTVTNGAGAGPGGGGGASAPLG-KYLWIRLALHEKRLAKIIEHLVSNANSYYDREALVADPDY 215
                               .:||. |:||||.||.||.|.||:.:||.|::.||::|||:.||..
Human   121 -------------------LSPLAIKHLWIRTALFEKVLDKIVHYLVENSSKYYEKEALLMDPVD 166

  Fly   216 GSILSSLLVGPCALEFTRAKTADHYWSDPCADELVQRHRISSGN-RTPPTTHRPIINFKRSLHTS 279
            |.||:||||||||||:|:.|||||:|:||.||||||||||.|.: |....|.||.:..::. |
Human   167 GPILASLLVGPCALEYTKMKTADHFWTDPSADELVQRHRIHSSHVRQDSPTKRPALCIQKR-H-- 228

  Fly   280 SEDTSSGSFKACSPASVAKDYVESLHQNSRTTLLYGKNNVLVLPKDVSEPMPGYLSLHQSIQSLT 344
                ||||... .|:..|:|||||||||||.|||||||||||.|:|..|.:||||||||:...:|
Human   229 ----SSGSMDD-RPSLSARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMT 288

  Fly   345 IKWTPNQLMNGYNDGD-GGDKSFYWSYALNINVDEIVYVHCHQNRGGDTGGTIILVGQDGVQRPP 408
            :|||||||||| :.|| ..:||.||.||:.|.::||||:||||.  .|:|||::||.|||:||||
Human   289 LKWTPNQLMNG-SVGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQ--VDSGGTVVLVSQDGIQRPP 350

  Fly   409 IHFPEGGHLQAFLSCLETGLLPHGQLDPPLWSQRGIGKLFPWPKSVRRHILPSVMEAGGSVTDET 473
            ..||:||||..||||||.|||||||||||||||||.||:|  ||..:|....|.........|:.
Human   351 FRFPKGGHLLQFLSCLENGLLPHGQLDPPLWSQRGKGKVF--PKLRKRSPQGSAESTSSDKDDDE 413

  Fly   474 PIDYVFRVVSKCQHEEFLA--------------SHPILELGRS---------------------- 502
            ..|||||::......||:|              :..::..|||
Human   414 ATDYVFRIIYPGMQSEFVAPDFLGSTSSVSVGPAWMMVPAGRSMLVVARGSQWEPARWDTTLPTP 478

  Fly   503 --------------------------SPRRKHLGSCSTTGSSDCSSKSLSIDQSSCETPLIQASQ 541
                                      |||:....|||.:||:|.||      .:.|.      .:
Human   479 SPKEQPPMPQDLMDVSVSNLPSLWQPSPRKSSCSSCSQSGSADGSS------TNGCN------HE 531

  Fly   542 STSIELVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGLVNGRIM-PDLAADE-EGLTRGKWLA 604
            ...::|:|..|:.||:||||||||||||||||||||||.|||..|: |||..|. :|||...|..
Human   532 RAPLKLLCDNMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQ 596

  Fly   605 MHEDGVVTGDLELYRLVYFGGVEPELRKEVWPYLLGHYDFGSTPEERKKQDETCKHYYETTMSEW 669
            ...|.....:.||.||:|:||::||:||.|||:|||||.||.|..|||:.||.....|..||:||
Human   597 YLHDSTSYEEQELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAEW 661

  Fly   670 LAVEAIVRQREKEKTALAVAKLSAEQA-------RLAANATSSSNPHQKLANGSQQLQLEHGNGE 727
            |..||||||||:|..|.|:||.|:..:       .|..::|.|:...|..::|.|.::|.
Human   662 LGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNIRLH----- 721

  Fly   728 EDQENLVLDEGENDVFDDNDFSDISDPGDLFDEPELGQEAEEQEQSNLEEEVFEKQEDEEDQEDH 792
                                 ||.|....:|      :..:|.||...|..:.|||
Human   722 ---------------------SDSSSSTQVF------ESVDEVEQVEAEGRLEEKQ--------- 750

  Fly   793 DQREMPRLSEKLVLEFQNIDNMEPLRLQENCFADSETENDLGLGLDSSGNILM-LSIKSSPSTSS 856
                 |::..      .|:.|       ..|..||        |..||.|... ||..|.||.|:
Human   751 -----PKIPN------GNLVN-------GTCSPDS--------GHPSSHNFSSGLSEHSEPSLST 789

  Fly   857 YETVGNEFLDMAEAKLEEEEPPGQLSKFHSADDVRLDNQDEEESSQPATAVIITEAASLDALDDD 921
            .::|    ||     .:...|.....:..|.||.:.......:...|...:.:.::...|.|.::
Human   790 EDSV----LD-----AQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELAVQDSLESDLLANE 845

  Fly   922 PTEEFTSRKTSLMSPLNEDITVVA---------------SLDALQE--------PKSAC------ 957
            ..:||.|...||...|.|...||.               |.|.|.|        |..|.
Human   846 SMDEFMSITGSLDMALPEKDDVVMEGWRSSETEKHGQADSEDNLSEEPEMESLFPALASLAVTTS 910

  Fly   958 ---VSPASSNGGVYSVELLEQFGLNLHRIEKDVQRCDRNYWYFANENLDKLRNVISTYVWEHLDV 1019
               |||.||:|..||.|||:.:.:|||||||||||||||||||...||:||||::.:|:|:|:::
Human   911 ANEVSPVSSSGVTYSPELLDLYTVNLHRIEKDVQRCDRNYWYFTPANLEKLRNIMCSYIWQHIEI 975

  Fly  1020 GYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSEMYDL 1084
            ||:||||||:||||||.|||:|::|||.:||:||.:|||.|||||.|||||||||||||||:::|
Human   976 GYVQGMCDLLAPLLVILDDEALAFSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFEL 1040

  Fly  1085 MDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIIL 1149
            |..||||||||||||||||||||||||||||..||.||||||::|.|:|||:||||:|.||||||
Human  1041 MHQNGDYTHFYFCYRWFLLDFKRELVYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIIL 1105

  Fly  1150 SNSMDFTDVIKFFNEMAERHNAQSILQLSRSLVLQLQTIIENK 1192
            .|:|||||:||||||||||||.:.:|:|:|.||.::||:||||
Human  1106 ENNMDFTDIIKFFNEMAERHNTKQVLKLARDLVYKVQTLIENK 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN_SGSM1_like	39..233	CDD:439049	86/197 (44%)
		PH_RUTBC	310..485	CDD:275431	105/175 (60%)
		TBC	947..1124	CDD:214540	126/193 (65%)
SGSM1	NP_001035037.1	RUN_SGSM1	20..196	CDD:439065	94/209 (45%)
		PH_RUTBC	254..425	CDD:275431	105/175 (60%)
		Important for interaction with RAB9A and RAB9B. /evidence=ECO:0000250|UniProtKB:Q8BPQ7	256..297		28/40 (70%)
		Required for interaction with RAP family members	301..350		28/50 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..411		16/35 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	700..830		41/205 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	871..894		4/22 (18%)
		TBC	<936..1105	CDD:214540	127/168 (76%)