Protein Alignment CG1695 and TBC1D8

DIOPT Version :9

• Sequence 1: NP_728346.2
• Gene: CG1695 / 33046
• FlyBaseID: FBgn0031116
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: XP_005263919.1
• Gene: TBC1D8 / 11138
• HGNCID: 17791
• Length: 1162
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 104/576 - (18%)
• Similarity: 191/576 - (33%)
• Gaps: 179/576 - (31%)

  Fly   745 DNDFSDISDPGDLFDEPELGQEAEEQEQSNLEEEVFEKQEDEEDQEDHDQREM-PRLSEKLVLEF 808
            :.|||...:..::|...|  |.|:...:..|:.|||:...|.::.....:|:: .|...:....|
Human   250 ERDFSMFLNLDEVFKVME--QLADVTLRRLLDNEVFDLDPDLQEPSQITKRDLEARAQNEFFRAF 312

  Fly   809 QNIDNMEPLRLQEN-----------------------CFADSETENDLGLGLDSSGNILM----- 845
            ..:...|.|....:                       |||..|         |....|::
Human   313 FRLPRKEKLHAVVDCSLWTPFSRCHTTGRMFASDSYICFASRE---------DGCCKIILPLREV 368

  Fly   846 LSIKSSPSTSSY---------ETVGNEFLDMAEAKLEEEEPPGQLSKFHSADDVRLDNQDEEESS 901
            :||:....||..         ..|..:|:::.:.....|....:|.:.|:...|..|...:::
Human   369 VSIEKMEDTSLLPHPIIVSIRSKVAFQFIELRDRDSLVEALLARLKQVHANHPVHYDTSADDD-- 431

  Fly   902 QPATAVIITEAAS---------LDALDDDPTEEFTSRKTSLMSP-------------------LN 938
               .|.::..:.|         |:.:....:||....|:.||.|                   ..
Human   432 ---MASLVFHSTSMCSDHRFGDLEMMSSQNSEESEKEKSPLMHPDALVTAFQQSGSQSPDSRMSR 493

  Fly   939 EDITV---------------------VASLDALQEPKSA----------CVSPASSNGGVYSVEL 972
            |.|.:                     :..|.|:..|:|.          .|:..:|:.|.|...:
Human   494 EQIKISLWNDHFVEYGRTVCMFRTEKIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNLV 558

  Fly   973 LEQFG---LNLHRIEKDVQRCDRNYWYFANE-NLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLL 1033
            .|..|   |....||:|:.|....:..|.|| .:..||.|::.|...:..:||.|.| :::..:|
Human   559 EESLGKCCLVTEEIERDLHRSLPEHPAFQNETGIAALRRVLTAYAHRNPKIGYCQSM-NILTSVL 622

  Fly  1034 VIFDDESLSYSCFCKLMERMIENFPS----GGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHF 1094
            :::..|..::.....:.|||:.::.:    |..:|.....     :::...:.:|.:...|.:..
Human   623 LLYTKEEEAFWLLVAVCERMLPDYFNHRVIGAQVDQSVFE-----ELIKGHLPELAEHMNDLSAL 682

  Fly  1095 -YFCYRWFLLDFKREL------------VYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRD 1146
             .....|||..|...:            .||.:.|.::                |.||:||...:
Human   683 ASVSLSWFLTLFLSIMPLESAVNVVDCFFYDGIKAIFQ----------------LGLAVLEANAE 731

  Fly  1147 IILSNSMD---------FTDVIK--------------FFNEMAERHNAQSILQLSR 1179
            .:.|:..|         |.|.||              ||::..|.:....|..|.|
Human   732 DLCSSKDDGQALMILSRFLDHIKNEDSPGPPVGSHHAFFSDDQEPYPVTDISDLIR 787

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431
		SRP68-RBD	<648..>713	CDD:304552
		TBC	947..1124	CDD:214540	42/207 (20%)
TBC1D8	XP_005263919.1	PH-GRAM1_TBC1D8	178..276	CDD:270156	7/27 (26%)
		PH-GRAM2_TBC1D8	318..413	CDD:270160	15/103 (15%)
		TBC	527..733	CDD:214540	45/227 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900