Protein Alignment CG1695 and TBC1D8

DIOPT Version :10

• Sequence 1: NP_728346.2
• Gene: CG1695 / 33046
• FlyBaseID: FBgn0031116
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: NP_001317277.1
• Gene: TBC1D8 / 11138
• HGNCID: 17791
• Length: 1155
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 104/576 - (18%)
• Similarity: 191/576 - (33%)
• Gaps: 179/576 - (31%)

  Fly   745 DNDFSDISDPGDLFDEPELGQEAEEQEQSNLEEEVFEKQEDEEDQEDHDQREM-PRLSEKLVLEF 808
            :.|||...:..::|...|  |.|:...:..|:.|||:...|.::.....:|:: .|...:....|
Human   243 ERDFSMFLNLDEVFKVME--QLADVTLRRLLDNEVFDLDPDLQEPSQITKRDLEARAQNEFFRAF 305

  Fly   809 QNIDNMEPLRLQEN-----------------------CFADSETENDLGLGLDSSGNILM----- 845
            ..:...|.|....:                       |||..|         |....|::
Human   306 FRLPRKEKLHAVVDCSLWTPFSRCHTTGRMFASDSYICFASRE---------DGCCKIILPLREV 361

  Fly   846 LSIKSSPSTSSY---------ETVGNEFLDMAEAKLEEEEPPGQLSKFHSADDVRLDNQDEEESS 901
            :||:....||..         ..|..:|:::.:.....|....:|.:.|:...|..|...:::
Human   362 VSIEKMEDTSLLPHPIIVSIRSKVAFQFIELRDRDSLVEALLARLKQVHANHPVHYDTSADDD-- 424

  Fly   902 QPATAVIITEAAS---------LDALDDDPTEEFTSRKTSLMSP-------------------LN 938
               .|.::..:.|         |:.:....:||....|:.||.|                   ..
Human   425 ---MASLVFHSTSMCSDHRFGDLEMMSSQNSEESEKEKSPLMHPDALVTAFQQSGSQSPDSRMSR 486

  Fly   939 EDITV---------------------VASLDALQEPKSA----------CVSPASSNGGVYSVEL 972
            |.|.:                     :..|.|:..|:|.          .|:..:|:.|.|...:
Human   487 EQIKISLWNDHFVEYGRTVCMFRTEKIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNLV 551

  Fly   973 LEQFG---LNLHRIEKDVQRCDRNYWYFANE-NLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLL 1033
            .|..|   |....||:|:.|....:..|.|| .:..||.|::.|...:..:||.|.| :::..:|
Human   552 EESLGKCCLVTEEIERDLHRSLPEHPAFQNETGIAALRRVLTAYAHRNPKIGYCQSM-NILTSVL 615

  Fly  1034 VIFDDESLSYSCFCKLMERMIENFPS----GGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHF 1094
            :::..|..::.....:.|||:.::.:    |..:|.....     :::...:.:|.:...|.:..
Human   616 LLYTKEEEAFWLLVAVCERMLPDYFNHRVIGAQVDQSVFE-----ELIKGHLPELAEHMNDLSAL 675

  Fly  1095 -YFCYRWFLLDFKREL------------VYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRD 1146
             .....|||..|...:            .||.:.|.::                |.||:||...:
Human   676 ASVSLSWFLTLFLSIMPLESAVNVVDCFFYDGIKAIFQ----------------LGLAVLEANAE 724

  Fly  1147 IILSNSMD---------FTDVIK--------------FFNEMAERHNAQSILQLSR 1179
            .:.|:..|         |.|.||              ||::..|.:....|..|.|
Human   725 DLCSSKDDGQALMILSRFLDHIKNEDSPGPPVGSHHAFFSDDQEPYPVTDISDLIR 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN_SGSM1_like	39..233	CDD:439049
		PH_RUTBC	310..485	CDD:275431
		TBC	947..1124	CDD:214540	42/207 (20%)
TBC1D8	NP_001317277.1	PH-GRAM1_TBC1D8	171..269	CDD:270156	7/27 (26%)
		PH-GRAM2_TBC1D8	311..406	CDD:270160	15/103 (15%)
		TBC	520..726	CDD:214540	45/227 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1046..1085