DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1695 and TBC1D3E

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_001278395.1	Gene:	TBC1D3E / 102723859	HGNCID:	27071	Length:	549	Species:	Homo sapiens

Alignment Length:	229	Identity:	53/229 - (23%)
Similarity:	74/229 - (32%)	Gaps:	71/229 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   577 HLSGLVNGRIMPDLAADE------EGLTRGKWLAMHEDGVVTGDLELY----RLV--YFGGVEPE 629
            || |:|:...:|.|.|.|      |...:.||:.|      .||.|.|    :|:  .:.|:...
Human    48 HL-GIVHETELPPLTAREAKQIRREISRKSKWVDM------LGDWEKYKSSRKLIDQAYKGMPMN 105

  Fly   630 LRKEVWPYLL----------GHYDFGSTPEERKKQDETC------------KHY-----YETTMS 667
            :|..:|..||          |.|..  ..|:.||..|..            ||.     |.|...
Human   106 IRGPMWSVLLNTEEMKLKNPGRYQI--MKEKGKKSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQR 168

  Fly   668 EWLAVEAIVRQREKEK---------TALAVAKLSAEQARLAANATSSSNPHQKLANGSQQLQLEH 723
            |.|.:.....:...|.         .||.:..|..|.|..|.        .|.||:....||..|
Human   169 ELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWAL--------VQLLASERHSLQGFH 225

  Fly   724 G------NGEEDQENLVLDEGENDVFDDNDFSDI 751
            .      .|.:||:..|:...:.......|..|:
Human   226 SPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDL 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431
		SRP68-RBD	<648..>713	CDD:304552	18/90 (20%)
		TBC	947..1124	CDD:214540
TBC1D3E	NP_001278395.1	TBC	99..312	CDD:214540	36/171 (21%)
TBC1D3E	NP_001278395.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..419
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900