DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1695 and tbc1d12b

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	XP_005169505.1	Gene:	tbc1d12b / 100332088	ZFINID:	ZDB-GENE-121214-108	Length:	771	Species:	Danio rerio

Alignment Length:	827	Identity:	168/827 - (20%)
Similarity:	273/827 - (33%)	Gaps:	254/827 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   498 ELGRSSPRRKHL---------GSCSTTGSSDCSSKSLSIDQSSCETPLIQASQS-TSIELVCSTM 552
            |.||..||...:         |..|.:|:|......|   |||.|.   :|::| ..:.|.|.
Zfish    41 EEGRPPPRIADVTDRQENIMQGMFSNSGASQREKGQL---QSSQEH---EATESCDEVNLPCG-- 97

  Fly   553 RRQIISRAFYGWLAYCRHLSTVRTHLSGLVNGRI---MPDLAADEEGLTRGKWLAMHED-GVVTG 613
                                      :.|.||..   .|:..|.:.....|..::..:| |:..|
Zfish    98 --------------------------AKLPNGHASHNAPERVACKSSSPAGSCVSSEDDHGIANG 136

  Fly   614 DLELYRLVYFGGVEPELRKEVWPYLLGHYDFGSTPEERKKQDETCKHYYETTMSEWLAVEAIVRQ 678
            :|    ||..|.....:...        :..|.||:|..:.       .||...|.|  ||: .|
Zfish   137 EL----LVDSGSAGDAVSSA--------FCSGETPDEAGES-------LETQAGETL--EAL-DQ 179

  Fly   679 REKEKT--ALAVAKLSAEQARLAANATSSSNP-HQKLANGSQQLQLEHGNGEEDQENLVLDEGEN 740
            .|:..|  .|.:......:.:|...:::|.:| ...|...|....|...:......:   |:.|:
Zfish   180 AERSSTDHCLGLQSSECNEGKLHRRSSTSPSPLKHSLRTFSSSTFLNTDSASLSPND---DDDED 241

  Fly   741 DVF------DDNDFSDIS------------------DPG-------DLFDEPELGQEAEEQEQSN 774
            :.|      ||..|.|:|                  .||       ||    .|||  .:|..|:
Zfish   242 ETFSTSDRPDDLRFMDVSLKSRNTYEISRRQSAPDNIPGVLSVAAVDL----TLGQ--RKQGISD 300

  Fly   775 L-EEEVFEKQEDEEDQEDH-------DQREMPRLSEKLVLEFQNIDNMEPLRLQENCFADSETEN 831
            : ...:|.:::.|......       ..||.|....|.:.:..|..|:..:          .|.|
Zfish   301 IFSRSLFTRKQREAQSAPGWKLFGKVPLRESPPKDSKTIQQESNPGNLTSV----------STPN 355

  Fly   832 DLGLGLDSSGNILMLSIKS--SPSTSSYETVGN-EFLDMAEAKLEEEEPPGQLSKFHSADDVRLD 893
                 |.|||.......||  |||..:.....| ||..::...|..|:.|..|.. .|.::.:..
Zfish   356 -----LLSSGEYEAKVCKSGQSPSLPAQSRRKNLEFEPLSTTALILEDRPANLPA-KSEEEAQRH 414

  Fly   894 NQDEEESSQPATAVIITEAASLDALDDDPTEEFTSRKTSLMSPLNED-----ITVVASLDALQEP 953
            .|:.:|        ::.||...:      .:|...:|..:.....::     ..||.:.:.|...
Zfish   415 RQEYDE--------MVAEAKKRE------LKEAQKKKKQMKERFKQEESIANAMVVWNTEILPNW 465

  Fly   954 KSACVS-----------PASSNGGVYSV----------ELLEQFGLNLHR--------------I 983
            :|...:           |.:..|.|:|:          :|.|.|   |.|              |
Zfish   466 ESMRGTRRVRDLWWQGLPPNVRGKVWSLAVGNELNITSDLYEIF---LSRAKERWKSFRETGSEI 527

  Fly   984 EKDVQRCDR----------------NYWYF--ANENLDKLRNVISTYVWEHLDVGYMQGMCDLVA 1030
            |.||...||                :.:.|  .....|.|.:|:..|.....||||:||| ..:|
Zfish   528 ESDVDSADRESSLDLIKLDISRTFPSLFIFQKGGPYHDLLHSVLGAYTCYRPDVGYVQGM-SFIA 591

  Fly  1031 PLLVIFDDESLSYSCFCKLM-------------ERMIENFPSGGAMDMHF-ANMRSLIQILDSEM 1081
            .:|::..:|:.::..|..|:             |.|::.|   .|.::.| .|:..|.....|
Zfish   592 AVLILNLEEADAFIAFANLLNKPCQMAFFRVDHELMLKYF---AAFEVFFEENLPRLFNHFKS-- 651

  Fly  1082 YDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLF-LALALLETYR 1145
            |:|       |...:...|....:.:.|..|.....|:|.     ...|...|| ..|.:|..|.
Zfish   652 YNL-------TPDLYLIDWIFTLYAKSLPLDVACRVWDVF-----CRDGEEFLFRTGLGILRLYE 704

  Fly  1146 DIILSNSMDFTDVIKFFNEMAERHNAQSILQLSRSLVLQLQTIIENK 1192
            :::|  .|||....:|...:.:....:.:.    |.:...|.|..|:
Zfish   705 ELLL--QMDFIHSAQFLTRLPDDTPPERLF----SCIASTQMISSNR 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431
		SRP68-RBD	<648..>713	CDD:304552	15/67 (22%)
		TBC	947..1124	CDD:214540	50/243 (21%)
tbc1d12b	XP_005169505.1	TPX2	407..>451	CDD:284337	7/57 (12%)
tbc1d12b	XP_005169505.1	TBC	478..708	CDD:214540	54/250 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900