DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1695 and tbc1d9b

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	XP_009305930.1	Gene:	tbc1d9b / 100332046	-ID:	-	Length:	1218	Species:	Danio rerio

Alignment Length:	841	Identity:	158/841 - (18%)
Similarity:	278/841 - (33%)	Gaps:	258/841 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   488 EEFLASHPILELGRSSP-----RRKHLGSCSTTGSSDCSSKSLSIDQSSCETP---LIQASQSTS 544
            ||.|.::.:....|::|     |||..|...........:..:.:|.|:...|   |.|..:|..
Zfish     6 EEVLLANALWVSERANPYFILQRRKGHGRGGGITGLLVGTLDVVLDSSARVAPYRILHQTGESQI 70

  Fly   545 I-ELVCSTMRRQIISRAFYGWLAYCRHLSTVR-----THLSGLVNGRIMPDLAADEEG------- 596
            . .:.|.:.|::|...  :.||. ...|.|:.     ..::..|.|:|...:|.:.:|
Zfish    71 FWNIACGSSRKEITEH--WEWLE-ANLLQTLSIFDNDDDITTFVKGKIQGIIAEENKGGKPQEDE 132

  Fly   597 ---------LTRGKWLAMHEDGVVTGDLELYRLVYFGGVEPELRKEVWPYL-LGHYDFGS----- 646
                     |...|...|.|:..:   :..|...|:.|..|   ::.|.|| :.|..|.|
Zfish   133 DPGKFREAELKMRKLFGMPEEEKL---VNYYPCSYWKGRVP---RQGWIYLSVNHLCFYSFLLGK 191

  Fly   647 ---------------------TPEERKKQDETCKHYY-------ET----------TMSEWLAVE 673
                                 .||..:......:|::       ||          .|.:.|..|
Zfish   192 EVSLVVQWTDVTQLDKNATLVFPESIRVSTRDTEHFFSMFLNINETFKLMEQLANIAMRQLLDNE 256

  Fly   674 AIVRQREKEKTALAVAK-LSAEQARLAANATSSSNPHQKLANGSQQLQLEHGNGEEDQENLVLDE 737
            :....|...|.|....| :||.:..|.|.|  .:..::.|...:|..:|               :
Zfish   257 SFAADRSLPKPANKTLKNVSALKRDLDARA--KNERYRALFRLTQDERL---------------D 304

  Fly   738 GENDVFDDNDFSDISDPGDLFDEPELGQEAEEQEQSNLEEEVFEKQEDEEDQEDHDQREMPRLSE 802
            |..|......|:.:...|.:|             .||.......::||              |.:
Zfish   305 GHTDCTLWTPFAKMHVVGQMF-------------VSNNYICFTSREED--------------LCQ 342

  Fly   803 KLVLEFQNIDNMEPLR---LQENCFADSETENDLGLGLDSSGNILMLSIKSSPSTSSYETVGNEF 864
            .::          |||   :.|...:.|...:.|.:...:....|..::|.           .:|
Zfish   343 LII----------PLREVTIVEKADSSSVLPSPLSISTKNKMTFLFANLKD-----------RDF 386

  Fly   865 LDMAEAKLEEEEPPGQLSKFHSADDVRLDNQDEEESSQPATAVI-ITEAASLDALDDD-PTEEFT 927
            |....:...:..|.|....        |.:::...|:.|:..|: ::|:|.:...... |    |
Zfish   387 LVQRISDFLQRTPDGPCGV--------LQSENPSPSTPPSPPVLSLSESAQMQHYSPSLP----T 439

  Fly   928 SRKTSL---MSPLNEDITVVASLDALQEP----------KSACV-------------SPASSNG- 965
            :||..|   ...:.|::....:.:.::|.          :..|:             .|.|..|
Zfish   440 ARKGLLQIYQQDVPEELGPKVTRERMKEESWKIHFFEFGRGVCMYRTSKTRELVLNGIPESLRGE 504

  Fly   966 ----------------GVYSVELLEQ-FG---LNLHRIEKDVQRCDRNYWYFANE-NLDKLRNVI 1009
                            |.|. .|:|| .|   |....||:|:.|....:..|.|| .:..||.|:
Zfish   505 LWLLFSGAQNEMATHPGYYG-NLVEQAMGRCTLATEEIERDLHRSMPEHHAFQNETGIAALRRVL 568

  Fly  1010 STYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPS----GGAMDMHFANM 1070
            :.|.:.:..:||.|.| ::|..:|:::..|..::.....|.|||:.::.:    |..:|
Zfish   569 TAYAYRNPGIGYCQAM-NIVTSVLLLYCTEEEAFWLLVALCERMLPDYYNTRVVGALVD------ 626

  Fly  1071 RSLIQILDSEMYDLMDSNGDYTHFY-------FCYRWFLLDFKRELVYDDVFATWEVIWAAKHIA 1128
            :.:.:.|..|...|:     |.|..       ....|||..|...:.:|..     |:.......
Zfish   627 QGVFEELTRECLPLL-----YEHMQDLGVISTISLSWFLTLFLSVMPFDSA-----VLLVDCFFY 681

  Fly  1129 SGHFVLF-LALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSILQLSRSLVLQLQTI 1188
            .|..|:| ::||:|....|.:||.|              :...|.:||......|:..||:
Zfish   682 EGIKVIFQVSLAVLHANMDQLLSCS--------------DEGEAMTILGRYLDNVVNKQTV 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431
		SRP68-RBD	<648..>713	CDD:304552	17/82 (21%)
		TBC	947..1124	CDD:214540	47/232 (20%)
tbc1d9b	XP_009305930.1	PH-GRAM1_TCB1D9_TCB1D9B	153..251	CDD:275420	16/103 (16%)
		PH-GRAM2_TCB1D9_TCB1D9B	300..395	CDD:270161	21/157 (13%)
		TBC	493..703	CDD:214540	52/227 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900