DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1695 and sgsm1

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_001106422.2	Gene:	sgsm1 / 100127590	XenbaseID:	XB-GENE-6043600	Length:	1096	Species:	Xenopus tropicalis

Alignment Length:	1226	Identity:	563/1226 - (45%)
Similarity:	740/1226 - (60%)	Gaps:	193/1226 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 AETELKERLIASVKKEVKQLMEEAVTKKYVHEESSSVTSLCGAVEACLSHGLRRRALGLFKTSST 89
            ||.:.:::|:.:|||||||:||||||:|:|||:||.:.|.|.|||||:.:||:|||.|..:::..
Frog     6 AEADTRQKLLKTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLYGLKRRAAGFLRSNKI 70

  Fly    90 TALIQKIAKICPEADYVSRRLLELELAQESHAVSGKRSSCSSDSIIKPKLLSKGSGSSNSVTTIN 154
            .||..|:||..|.|:.:.|::.:||...|:     ||:..              .|...||....
Frog    71 AALFMKVAKSFPLAEELCRKVQDLEQLLEN-----KRNQM--------------QGVQESVRKAQ 116

  Fly   155 TVTNGAGAGPGGGGGASAPLGKYLWIRLALHEKRLAKIIEHLVSNANSYYDREALVADPDYGSIL 219
            .:.|           .|....|:||||.||.||.|.||:.:||.|.|.||::|||:.||..|.||
Frog   117 KLPN-----------LSPQAIKHLWIRTALIEKVLDKIVLYLVENCNKYYEKEALLMDPVDGPIL 170

  Fly   220 SSLLVGPCALEFTRAKTADHYWSDPCADELVQRHRISSGN-RTPPTTHRPIINFKRSLHTSSEDT 283
            :||||||||||:|:.|||||:|:||.||||||||||.|.: |....|.||.:..::. |
Frog   171 ASLLVGPCALEYTKMKTADHFWTDPSADELVQRHRIHSSHCRQDSPTKRPALCIQKR-H------ 228

  Fly   284 SSGSFKACSPASVAKDYVESLHQNSRTTLLYGKNNVLVLPKDVSEPMPGYLSLHQSIQSLTIKWT 348
            ||||... .|:..|:|||||||||||.|||:|||||:|.|:|..|.:|||||||||..::|:|||
Frog   229 SSGSMDD-RPSMSARDYVESLHQNSRATLLFGKNNVMVQPRDDMEAIPGYLSLHQSADTMTLKWT 292

  Fly   349 PNQLMNGYNDGD-GGDKSFYWSYALNINVDEIVYVHCHQNRGGDTGGTIILVGQDGVQRPPIHFP 412
            ||||||| :.|| ..:||.||.||:.|.::||||:||||.  .|:|||::||.|||:||||:.||
Frog   293 PNQLMNG-SVGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQ--VDSGGTVVLVSQDGIQRPPLRFP 354

  Fly   413 EGGHLQAFLSCLETGLLPHGQLDPPLWSQRGIGKLFPWPKSVRRHILPSVMEAGGSVTDETPIDY 477
            .||||..||||||.|||||||||||||||||.||:||   .:|:.......|:.....::...||
Frog   355 RGGHLLQFLSCLENGLLPHGQLDPPLWSQRGKGKVFP---KLRKRSPQGSSESASDKEEDEATDY 416

  Fly   478 VFRVV---SKCQHEEFLASHPILELG-------RSSPRRKHLGSCSTTGSSDCSSKSLSIDQSSC 532
            |||::   |:|   ||:|...|...|       :.|.|:....|||.:||||..      ..:.|
Frog   417 VFRIIYPGSQC---EFVAQELIDPQGGGLPSMWQPSTRKSSCSSCSQSGSSDGG------PSNGC 472

  Fly   533 ETPLIQASQSTSIELVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGLVNGRIM-PDLAADEE- 595
            .      .:...::::|..|:.||:||||||||||||||||||||||.|||.:|: ||:..|..
Frog   473 N------HERAPLKMLCDNMKYQIVSRAFYGWLAYCRHLSTVRTHLSALVNHKIVYPDVPVDASF 531

  Fly   596 GLTRGKWLAMHEDGVVTGDLELYRLVYFGGVEPELRKEVWPYLLGHYDFGSTPEERKKQDETCKH 660
            |||...|....||.....:.||.||:|:||::.|:|:||||:|||||.||.|.|:|::.||..:.
Frog   532 GLTVAIWQKYLEDSKSYEEQELLRLIYYGGIQHEIRREVWPFLLGHYQFGMTEEDRREVDEQIRA 596

  Fly   661 YYETTMSEWLAVEAIVRQREKEKTALAVAKLSAEQARLAANATSSSNPHQKLANGSQQLQLE--- 722
            .||.||:|||..||||||||||..|.|:.|.|                    :..|..:|::
Frog   597 CYEQTMAEWLGCEAIVRQREKESHAAALLKCS--------------------SGASLDIQIQRMM 641

  Fly   723 HGNGEEDQENLVLDEGENDVFDDNDFSDISDPGDLFDEPELGQEAEEQEQSNLEEEVFEKQEDEE 787
            |      :::.|.:|.......|..                 ..|..|..|:...:|||..|:.|
Frog   642 H------RDSTVSNESSQSCSSDRQ-----------------NHARLQSDSSSSTQVFESVEEAE 683

  Fly   788 DQEDHDQREMP-RLSEKLVLEFQNIDNMEPLRLQENCFADSETENDLGLGLDSSGNILMLSIKSS 851
            ..|...:...| ::|...|             ....|..||        |..||.|   .||.|.
Frog   684 QIEARSEDSKPTKISNGTV-------------ANGTCSPDS--------GHPSSRN---FSITSG 724

  Fly   852 PSTSSYETVGNEFLDMAEAK--LEEEEPPGQLSKFHSADDVRLDNQDEEESSQPATAVIITEAAS 914
            .|..|:.|..|..|:..:..  |..::...::.|..::|.:..:|:         ||.::....|
Frog   725 YSEQSFSTDDNASLETNKNSLYLHMKQGTAEVKKQATSDIILPENK---------TAEVLPIQDS 780

  Fly   915 LD-------ALDD-----DPTEE-FTSRKTSLMSPLN-------EDITVVASLDAL-QEPK---- 954
            ||       :|||     :.|:: ...::|:::|.:.       |..::|.|.|.| :||:
Frog   781 LDGEVTANESLDDFLSITESTDDLLPDKETAVLSVVETWPDSEAEKESLVGSEDNLSEEPEMESL 845

  Fly   955 ------------SAC-VSPASSNGGVYSVELLEQFGLNLHRIEKDVQRCDRNYWYFANENLDKLR 1006
                        :.| :||.||.|..||.|||:.:.:|||||||||||||||||||...||:|||
Frog   846 YPQLDSLVVIDATVCEMSPVSSTGVTYSQELLDMYTINLHRIEKDVQRCDRNYWYFTPANLEKLR 910

  Fly  1007 NVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMR 1071
            ||:.:|||:|:::||:||||||:||||||.|||:.::|||.:||:||.:|||.|||||.||||||
Frog   911 NVMCSYVWQHIEIGYVQGMCDLLAPLLVILDDEAKAFSCFTELMKRMNQNFPHGGAMDTHFANMR 975

  Fly  1072 SLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLFL 1136
            |||||||||:::||..||||||||||||||||||||||||||||:.||.|||||||:|.|||||:
Frog   976 SLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFSVWETIWAAKHISSAHFVLFI 1040

  Fly  1137 ALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSILQLSRSLVLQLQTIIENK 1192
            ||||:|.||||||.|:|||||:||||||||||||.:.||:|::.||.::||:||||
Frog  1041 ALALVEVYRDIILENNMDFTDIIKFFNEMAERHNIKHILKLAQDLVYKVQTLIENK 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855	69/173 (40%)
		PH_RUTBC	310..485	CDD:275431	103/178 (58%)
		SRP68-RBD	<648..>713	CDD:304552	25/64 (39%)
		TBC	947..1124	CDD:214540	126/194 (65%)
sgsm1	NP_001106422.2	RUN	44..186	CDD:367169	68/171 (40%)
		PH_RUTBC	254..424	CDD:275431	102/175 (58%)
		TBC	872..1053	CDD:214540	136/180 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	299	1.000	Domainoid score	I1424
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	958	1.000	Inparanoid score	I332
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171826at2759
OrthoFinder	1	1.000	-	-		FOG0002045
OrthoInspector	1	1.000	-	-		mtm9377
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1347
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060