DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mal and MOCOS

DIOPT Version :9

Sequence 1:	NP_001285493.1	Gene:	mal / 33045	FlyBaseID:	FBgn0002641	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	NP_060417.4	Gene:	MOCOS / 55034	HGNCID:	18234	Length:	888	Species:	Homo sapiens

Alignment Length:	857	Identity:	316/857 - (36%)
Similarity:	458/857 - (53%)	Gaps:	161/857 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EFSRLASNKSVYLDHAGTTLYAESQVTAAAEQLQRNVICNPH----TCRLTGDFVDQVRFKILEF 79
            ||||||.  :|||||||.||:::||:.:....|..|...|||    :.:||.|.|:|||::||..
Human    42 EFSRLAG--TVYLDHAGATLFSQSQLESFTSDLMENTYGNPHSQNISSKLTHDTVEQVRYRILAH 104

  Fly    80 FNTTAEDYHVIFTANATAALSLVAENFDFGSSG------EFHFCQENHTSVLGMRE--------- 129
            |:||||||.|||||.:||||.||||.|.:.|.|      .|.:..::||||:|||.
Human   105 FHTTAEDYTVIFTAGSTAALKLVAEAFPWVSQGPESSGSRFCYLTDSHTSVVGMRNVTMAINVIS 169

  Fly   130 -RVRENGIYMLRENEISGGK------HKANGKVHEVSGKTGNSLLTFSAQCNFSGYKIPLEVIEQ 187
             .||...::...|...|...      |                |..:.||.||||.:.||..||:
Human   170 TPVRPEDLWSAEERSASASNPDCQLPH----------------LFCYPAQSNFSGVRYPLSWIEE 218

  Fly   188 I---QIDGLAKPGKELWSSLGEKKKNMHNDYYICLDAASFVATSPLDLQKYRPDYVCLSFYKIFG 249
            :   ::..::.|||                :::.|||||:|:||||||..::.|:|.:|||||||
Human   219 VKSGRLHPVSTPGK----------------WFVLLDAASYVSTSPLDLSAHQADFVPISFYKIFG 267

  Fly   250 YPTGVGALLVSRRGAEVFQKRRFFGGGTINYAYPHAMDYQL-RETFHQRYEDGTLPFLSIVGLLE 313
            :|||:|||||..|.|.:.:| .:|||||.: ||....|:.: |::..||:||||:.||.::.|..
Human   268 FPTGLGALLVHNRAAPLLRK-TYFGGGTAS-AYLAGEDFYIPRQSVAQRFEDGTISFLDVIALKH 330

  Fly   314 GFRTLERLVPRTDEFSTMERISRHVFGLAKYLEDQLRQLHHPNGEPLVKLYNKVGYQDKSRQGGI 378
            ||.|||||.      ..||.|.:|.|.||:|....|..|.:|||.|:|::|:...:.....||.|
Human   331 GFDTLERLT------GGMENIKQHTFTLAQYTYVALSSLQYPNGAPVVRIYSDSEFSSPEVQGPI 389

  Fly   379 VAFNVRTESGSFVGFGEIACVAALHGILLRTGCFCNIGACQYYLGLDEDALDAIYKRAGRICGDY 443
            :.|||..:.|:.:|:.::..:|:|:.|.||||||||.||||.:||:..:.:...: :||.:|||.
Human   390 INFNVLDDKGNIIGYSQVDKMASLYNIHLRTGCFCNTGACQRHLGISNEMVRKHF-QAGHVCGDN 453

  Fly   444 FDLIDGQPTGAVRVSFGYMTTIQDVDKLLQMLRSSYLATK---PLQRIQ---------FIEEQAE 496
            .|||||||||:||:|||||:|:.||...|:.:..:.|.:.   |:.:..         ..:.||:
Human   454 MDLIDGQPTGSVRISFGYMSTLDDVQAFLRFIIDTRLHSSGDWPVPQAHADTGETGAPSADSQAD 518

  Fly   497 QLPPLLKER--------------------------------VQLLRPK----------------- 512
            .:|.::..|                                |...:|.
Human   519 VIPAVMGRRSLSPQEDALTGSRVWNNSSTVNAVPVAPPVCDVARTQPTPSEKAAGVLEGALGPHV 583

  Fly   513 LLQMAIYPVKSCAAFKIELPGSWPLTDQGLKYDREWMIVDMNGMALTQKRCTELCLIRPVIKVDQ 577
            :..:.:||:||||||::.   .||:.:|||.|||.||:|:.||:.|:||:...||||:|.|.:.|
Human   584 VTNLYLYPIKSCAAFEVT---RWPVGNQGLLYDRSWMVVNHNGVCLSQKQEPRLCLIQPFIDLRQ 645

  Fly   578 LELQFGENSTISVPLSLDDQAADTAKCVSKVCRQPVEGLDCGDRVAQWLSENLGMEGLRLLRQS- 641
            ..:.........:.:.|::.:..|....|:||...|...|||::::.|||...| ....|::||
Human   646 RIMVIKAKGMEPIEVPLEENSERTQIRQSRVCADRVSTYDCGEKISSWLSTFFG-RPCHLIKQSS 709

  Fly   642 -GQRNSSKDQQK---------LSLVNQAQFLLLNKSSVRSLQFE---------EPLDETVD---R 684
             .|||:.|...|         |||||:||:||:|.||:..|..:         |.|....|   |
Human   710 NSQRNAKKKHGKDQLPGTMATLSLVNEAQYLLINTSSILELHRQLNTSDENGKEELFSLKDLSLR 774

  Fly   685 FRANIIIDTGSAFEELTYKALSIGGIQFQVEGPCQRCDMICINQRTGERSPETLTTISRLQKGRM 749
            |||||||:...||||..:..:|||.::|||.|||.||.||||:|:||:|:......:|..::.::
Human   775 FRANIIINGKRAFEEEKWDEISIGSLRFQVLGPCHRCQMICIDQQTGQRNQHVFQKLSESRETKV 839

  Fly   750 RFGIYITRIPQD 761
            .||:|:.....|
Human   840 NFGMYLMHASLD 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mal	NP_001285493.1	PLN02724	17..753	CDD:215384	313/847 (37%)
		AAT_I	29..475	CDD:302748	198/475 (42%)
		MOSC_N	511..633	CDD:281474	45/138 (33%)
		MOSC	651..754	CDD:281471	51/123 (41%)
MOCOS	NP_060417.4	MOSC_N	28..866	CDD:332863	316/857 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147930
Domainoid	1	1.000	241	1.000	Domainoid score	I2245
eggNOG	1	0.900	-	-		E1_COG0520
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9931
Inparanoid	1	1.050	524	1.000	Inparanoid score	I1257
Isobase	1	0.950	-	0	Normalized mean entropy	S4621
OMA	1	1.010	-	-		QHG55229
OrthoDB	1	1.010	-	-		D394559at2759
OrthoFinder	1	1.000	-	-		FOG0006590
OrthoInspector	1	1.000	-	-		oto89336
orthoMCL	1	0.900	-	-		OOG6_102414
Panther	1	1.100	-	-	LDO	PTHR14237
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2650
SonicParanoid	1	1.000	-	-		X4833
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	18	17.750