DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mal and mocs-1

DIOPT Version :9

Sequence 1:	NP_001285493.1	Gene:	mal / 33045	FlyBaseID:	FBgn0002641	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	NP_510552.2	Gene:	mocs-1 / 187534	WormBaseID:	WBGene00010983	Length:	709	Species:	Caenorhabditis elegans

Alignment Length:	773	Identity:	269/773 - (34%)
Similarity:	408/773 - (52%)	Gaps:	135/773 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 YLDHAGTTLYAESQVTAAAEQLQRNVICNPH----TCRLTGDFVDQVRFKILEFFNTTAEDYHVI 90
            ||||||:||.::.|:...|:|..:.::.|||    |...|...|:..|.:||::||||::||.|:
Worm     3 YLDHAGSTLPSKIQLEEVAKQQSQLILANPHSHHATAVKTKQIVNSARLRILQYFNTTSDDYFVV 67

  Fly    91 FTANATAALSLVAENFDF---------------GSSGEFHFCQENHTSVLGMRERVRENGIYMLR 140
            .|.|.|..|.:|||||.|               |.|....:..::|.||:|:|
Worm    68 LTNNTTHGLKIVAENFKFGQKTHSILNIASVLHGGSSNLGYLYDSHHSVVGLR------------ 120

  Fly   141 ENEISGGKHKANGKVHEVS------------GKTGNSLLTFSAQCNFSGYKIPLEVIEQIQIDGL 193
                    |..||||:.:|            ....:||...:|..||.|.|..||.:.::|..|
Worm   121 --------HVVNGKVNSISCVNEESILEHEIPDVEHSLFVLTAMSNFCGKKYSLESVHRLQEKG- 176

  Fly   194 AKPGKELWSSLGEKKKNMHNDYYICLDAASFVATSPLDLQKYRPDYVCLSFYKIFGYPTGVGALL 258
                   |:              :||||||||::|.|||.:.||:::..|||||||||||:||||
Worm   177 -------WA--------------VCLDAASFVSSSALDLSQQRPNFIAFSFYKIFGYPTGIGALL 220

  Fly   259 VSRRGAEVFQKRRFFGGGTINYAYPHAMDYQLRETFHQRYEDGTLPFLSIVGLLEGFRTLERLVP 323
            |.:..|.:.:|.. |.|||:......:|.:.||| |.:.:|:|||.:..|..|.:||..:|
Worm   221 VRKDSAHLIEKTS-FAGGTVQSVDEMSMFFVLRE-FERAFEEGTLNYYGIAQLQKGFEEIE---- 279

  Fly   324 RTDEFSTMERISRHVFGLAKYLEDQLRQLHHPNGEPLVKLYNK-VGYQDKSRQGGIVAFNVRTES 387
            |....|::..::.|:...|.|:   |:...||||.|:|::|:: ..:::..:||.|||||::...
Worm   280 RCGGISSIRNLTHHLCKNALYM---LKSKKHPNGRPVVEIYSQSEQFENPDKQGPIVAFNLKRPD 341

  Fly   388 GSFVGFGEIACVAALHGILLRTGCFCNIGACQYYLGLDEDALDAIYKRAGRICGDYFDLIDGQPT 452
            |.:.|:.|:..:.|:.||.||||||||||||:.|||:..:.:.....: |:.|||..|||:|.||
Worm   342 GGYYGYTEVEKMCAIFGIELRTGCFCNIGACKKYLGITSEMIQENMSK-GKRCGDEIDLINGTPT 405

  Fly   453 GAVRVSFGYMTTIQDVDKLLQMLRSSYLATKPLQRIQFIEEQAEQLP-PLLKERVQLLRPKLLQM 516
            ||:|:|||..:|..|:..|.||:.:.:...         |.||:..| |:   .::...|.::.:
Worm   406 GAIRISFGRTSTEHDITALEQMIDTCFTEG---------EHQAQSKPDPM---NIESYSPTVVNL 458

  Fly   517 AIYPVKSCAAFKIELPGS-----WPLTDQGLKYDREWMIVDMNGMALTQKRCTELCLI-RPVIKV 575
            ..:|:||.        ||     :.||.:|.|.|||::||: :.:.|..|...|||:: ..::..
Worm   459 FSFPIKSV--------GSVGRKRYELTARGFKNDREFLIVN-DDVTLNLKTHPELCMLTATIVDD 514

  Fly   576 DQLELQ-FGENSTISVP--LSLDDQAADTAKCVSKVCRQPVEGLDCGDRVAQWLSENLGMEGLRL 637
            |||.:| |.:|..:.:|  |||.|..|      ..||:..:..:||||:|.:||...|..:..||
Worm   515 DQLLIQTFDQNENLVLPMSLSLKDNGA------KLVCKNTIATMDCGDKVGKWLDNALDRQNCRL 573

  Fly   638 LRQSGQRNSSKDQQKLSLVNQAQFLLLNKSSV----RSLQFEEPLDETVDRFRANIIIDTGSAFE 698
            ||.:       :..|.:.||.:.|||:|::||    |.:..|  :.|.:.|||:||::.....|.
Worm   574 LRVA-------EDSKKNFVNDSPFLLINEASVYMLSRYINME--VREILTRFRSNIVVRGLPPFI 629

  Fly   699 ELTYKALSIGGIQFQVEGPCQRCDMICINQRTGERSPETLTTISRLQ-KGRMRFGIYI 755
            |.|.|.|||..::|:|...|.||:|||::..|||:.|..|..:...: |.:|.|||||
Worm   630 EDTAKRLSIENLEFEVVDKCTRCEMICVDPMTGEKDPSLLLALRDYRNKQKMTFGIYI 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mal	NP_001285493.1	PLN02724	17..753	CDD:215384	265/769 (34%)
		AAT_I	29..475	CDD:302748	173/476 (36%)
		MOSC_N	511..633	CDD:281474	42/130 (32%)
		MOSC	651..754	CDD:281471	41/107 (38%)
mocs-1	NP_510552.2	PLN02724	3..705	CDD:215384	269/773 (35%)
		AAT_I	3..424	CDD:302748	171/472 (36%)
		MOSC_N	452..569	CDD:281474	42/131 (32%)
		MOSC	579..688	CDD:281471	44/111 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159888
Domainoid	1	1.000	210	1.000	Domainoid score	I1651
eggNOG	1	0.900	-	-		E1_COG0520
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9931
Inparanoid	1	1.050	408	1.000	Inparanoid score	I1069
Isobase	1	0.950	-	0	Normalized mean entropy	S4621
OMA	1	1.010	-	-		QHG55229
OrthoDB	1	1.010	-	-		D394559at2759
OrthoFinder	1	1.000	-	-		FOG0006590
OrthoInspector	1	1.000	-	-		oto18939
orthoMCL	1	0.900	-	-		OOG6_102414
Panther	1	1.100	-	-	LDO	PTHR14237
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2650
SonicParanoid	1	1.000	-	-		X4833
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750