DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mal and mocos

DIOPT Version :9

Sequence 1:	NP_001285493.1	Gene:	mal / 33045	FlyBaseID:	FBgn0002641	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	XP_002941031.3	Gene:	mocos / 100490959	XenbaseID:	XB-GENE-13579780	Length:	862	Species:	Xenopus tropicalis

Alignment Length:	825	Identity:	300/825 - (36%)
Similarity:	444/825 - (53%)	Gaps:	127/825 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EFSRLASNKSVYLDHAGTTLYAESQVTAAAEQLQRNVICNPHT-C---RLTGDFVDQVRFKILEF 79
            ||||:..  ..|||:|||||:.:|.:....:.|..||..|||: |   |||.:.|:|.|::||:.
Frog    44 EFSRIGD--MTYLDNAGTTLFPQSLLDGFMKDLSENVYGNPHSHCISSRLTYETVEQTRYRILQH 106

  Fly    80 FNTTAEDYHVIFTANATAALSLVAENFDF------GSSGEFHFCQENHTSVLGMRERVRENGIY- 137
            |||::|||.|||||.:|||:.||||.|.:      .:...|.:..:|||||:|:|...:...:.
Frog   107 FNTSSEDYTVIFTAGSTAAMKLVAEIFPWTPNCLDNTGSRFCYLTDNHTSVIGIRGITKIINVLS 171

  Fly   138 -------MLRENEISGGKHKANGKVHEVSGKTGNSLLTFSAQCNFSGYKIPLEVIEQIQID---G 192
                   ||:...:....|. .|:.|    ||.: |..:.||.||||.|.||..||:|::.   .
Frog   172 VPVEPEDMLQSKNLESDYHH-QGEYH----KTPH-LFCYPAQSNFSGTKYPLAWIEKIRLGKLFP 230

  Fly   193 LAKPGKELWSSLGEKKKNMHNDYYICLDAASFVATSPLDLQKYRPDYVCLSFYKIFGYPTGVGAL 257
            |..||  .|              ::.|||:|:|:||||||..|:||:|.:|||||||:|||:|||
Frog   231 LGTPG--CW--------------FVLLDASSYVSTSPLDLSSYQPDFVTISFYKIFGFPTGLGAL 279

  Fly   258 LVSRRGAEVFQKRRFFGGGTINYAYPHAMDYQL-RETFHQRYEDGTLPFLSIVGLLEGFRTLERL 321
            :||.|...:.:| .:||||| :.||....|:.: :.:...||||||:.||.|:.:..||.|||||
Frog   280 IVSNRVTHLLRK-NYFGGGT-SAAYLSGEDFYVPKASTSDRYEDGTISFLDIIAIKYGFDTLERL 342

  Fly   322 VPRTDEFSTMERISRHVFGLAKYLEDQLRQLHHPNGEPLVKLYNKVGYQDKSRQGGIVAFNVRTE 386
            .      ..||.|..|...||.|....|..|.:.||..::::|:...::....||.::.|||..|
Frog   343 T------GGMEHIQNHTHTLASYTYSVLSALRYANGASVIQIYSDTEFRMLDVQGPVINFNVLDE 401

  Fly   387 SGSFVGFGEIACVAALHGILLRTGCFCNIGACQYYL-GLDEDALDAIYKRAGRICGDYFDLIDGQ 450
            ||..:|:.::..:|:|:.|..|||||||.||||.:| ..:.|....:  .||.:|||..|:|:||
Frog   402 SGGIIGYSQVDKLASLYNIHFRTGCFCNSGACQKHLRNSNMDVKQNL--MAGHVCGDNIDVINGQ 464

  Fly   451 PTGAVRVSFGYMTTIQDVDKLLQMLRSSYL--------ATKPLQR---------------IQFIE 492
            |||::|:|||:|:|.:|....:..:...::        ||:.|||               :|:::
Frog   465 PTGSIRISFGFMSTFEDARVFITFIIECFIKKPTYKLYATESLQRQYQTNRLTESDTSKEVQYLQ 529

  Fly   493 EQAEQLPPLLKERVQLL----------------------RPKLLQMA---IYPVKSCAAFKIELP 532
            ........:......:|                      ..|.:.:|   :||:||||.|::
Frog   530 NNRSHCEDVCLPHNHILNNVSMASNICTCKSREISSLSTNHKAITLAAIYLYPIKSCAPFQV--- 591

  Fly   533 GSWPLTDQGLKYDREWMIVDMNGMALTQKRCTELCLIRPVI--KVDQLELQFGENSTISVPLSLD 595
            ..||:|:|||.:||.||||:.|.:..:||...:||||.|.|  |.:.:.::......|..|| :|
Frog   592 SQWPVTEQGLLFDRNWMIVNENRVCFSQKNEPKLCLIHPSIDLKKNIMIIKAKGMDPIETPL-MD 655

  Fly   596 DQAADTAKCVSKVCRQPVEGLDCGDRVAQWLSENLGMEGLRLLRQSGQ----RNSSK------DQ 650
            |..|....|.:|||...|...|||:::|.|||..|..: ..|:|||..    .|:::      ..
Frog   656 DSDAKAPVCQNKVCGDRVHTYDCGEKIADWLSRFLNRK-CHLIRQSSNFSRFANANRKGLLGVPH 719

  Fly   651 QKLSLVNQAQFLLLNKSSVRSL--QFEE---PLDETVDRFRANIIIDTGSAFEELTYKALSIGGI 710
            ..|||||:||:||:|::|:..|  |.|.   .:|:...||||||:|:....|||..:..:.|.|:
Frog   720 STLSLVNEAQYLLVNRASIVYLRQQLESSDIEIDQLTQRFRANIVINGSQPFEEENWAEVFIDGL 784

  Fly   711 QFQVEGPCQRCDMICINQRTGERSPETLTTISRLQKGRMRFGIYI 755
            .|||.|.|.||.:|||:|.|||:..:...|:|..::|:..||:|:
Frog   785 HFQVSGKCNRCQIICIDQHTGEKKKDVFQTLSTCREGKATFGMYL 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mal	NP_001285493.1	PLN02724	17..753	CDD:215384	298/821 (36%)
		AAT_I	29..475	CDD:302748	187/468 (40%)
		MOSC_N	511..633	CDD:281474	50/126 (40%)
		MOSC	651..754	CDD:281471	46/107 (43%)
mocos	XP_002941031.3	PLN02724	30..848	CDD:215384	300/825 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	216	1.000	Domainoid score	I2648
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1527
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394559at2759
OrthoFinder	1	1.000	-	-		FOG0006590
OrthoInspector	1	1.000	-	-		oto103172
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4833
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060