Protein Alignment CG11710 and TRIP4

DIOPT Version :9

• Sequence 1: NP_001285492.1
• Gene: CG11710 / 33044
• FlyBaseID: FBgn0031115
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_057297.2
• Gene: TRIP4 / 9325
• HGNCID: 12310
• Length: 581
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 193/569 - (33%)
• Similarity: 306/569 - (53%)
• Gaps: 82/569 - (14%)

  Fly     9 LSKCLDCVITDQMLAAILNIKDDYEFDNYFGNLLSEDNEEHRMFLVNCRRMLLSGKQPRNNGKYL 73
            |.|.....::::::..:|:|:...|...|..:||..:..:...|:..     |..|..:|:.:.:
Human    20 LRKTFGLDVSEEIIQYVLSIESAEEIREYVTDLLQGNEGKKGQFIEE-----LITKWQKNDQELI 79

  Fly    74 SPPL---------------------------------APTSPN-----------CPKQNISKGAK 94
            |.||                                 |.|.|:           ...|..|...|
Human    80 SDPLQQCFKKDEILDGQKSGDHLKRGRKKGRNRQEVPAFTEPDTTAEVKTPFDLAKAQENSNSVK 144

  Fly    95 GKSGKHVNLYASDGRVQGD--TIILKGRRHCDCQAGQHKLINNCLGCGRIVCEQEGSGPCLSCGD 157
            .|: |.||||..:|:   |  .::|.||..|||...:||||||||.|||||||||||||||.||.
Human   145 KKT-KFVNLYTREGQ---DRLAVLLPGRHPCDCLGQKHKLINNCLICGRIVCEQEGSGPCLFCGT 205

  Fly   158 PVRTPEEEQQLAKAAREK--------GGTKSAAKQGKKSTKEL-------STQALDKALAQRDRL 207
            .|.|.||:..|.:.:.:.        .|.:::.|. ..|||:|       ....|:||:..:|:|
Human   206 LVCTHEEQDILQRDSNKSQKLLKKLMSGVENSGKV-DISTKDLLPHQELRIKSGLEKAIKHKDKL 269

  Fly   208 LEYDKNSEKRTTVIDDELDYF-QENSVWLSDAEREKFEKLHREMEEVKHGSRMKRKIRVDFAGRE 271
            ||:|:.|.:||.|||||.||| .:::.|||..|||..:|...|:.|::|.||:.:|:.:|||||:
Human   270 LEFDRTSIRRTQVIDDESDYFASDSNQWLSKLERETLQKREEELRELRHASRLSKKVTIDFAGRK 334

  Fly   272 LPEEPTISKEYEQQVISELAAVSKASGVGSNWSASSVTGHSALTLAPHLNM-TKPPVY----KPS 331
            :.||.....||..::...:.|::..: :....:....:....|.:..:.|| ..||.:    ..:
Human   335 ILEEENSLAEYHSRLDETIQAIANGT-LNQPLTKLDRSSEEPLGVLVNPNMYQSPPQWVDHTGAA 398

  Fly   332 KESKSWPAPAAGSDWLERTYN-RVQDKELLEMQDMRQCLSMHQPWASLLVAGIKKHEGRVWYSEH 395
            .:.|::.:...|.::....:. |:||:|..|..|...|||:|||||||||.|||:.|||.||:.|
Human   399 SQKKAFRSSGFGLEFNSFQHQLRIQDQEFQEGFDGGWCLSVHQPWASLLVRGIKRVEGRSWYTPH 463

  Fly   396 RGRLWIASTSKEPHAEDIAQMEGFYKVLYGDPDIKFPSHYPTSSLLGCVHVDSCLPQEEYRELYP 460
            |||||||:|:|:|..:::::::..|::|.| .|::||:.||:..|||||.:..||.|::::|.:|
Human   464 RGRLWIAATAKKPSPQEVSELQATYRLLRG-KDVEFPNDYPSGCLLGCVDLIDCLSQKQFKEQFP 527

  Fly   461 --NGESESPYVFVCTKPEQLNILLPVHGDHKIYELPLKTHTAACKTLLR 507
              :.||:||:||:|..|:::.:..|:.|:.||::|..|.|..|.|.|::
Human   528 DISQESDSPFVFICKNPQEMVVKFPIKGNPKIWKLDSKIHQGAKKGLMK 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11710	NP_001285492.1	zf-C2HC5	120..168	CDD:283802	33/47 (70%)
		ASCH_ASC-1_like	367..478	CDD:119346	57/112 (51%)
TRIP4	NP_057297.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	97..118		0/20 (0%)
		zf-C2HC5	168..216	CDD:310664	33/47 (70%)
		Mediates interaction with DDRGK1. /evidence=ECO:0000269|PubMed:25219498	200..300		36/100 (36%)
		Mediates interaction with UFL1. /evidence=ECO:0000269|PubMed:25219498	300..400		25/100 (25%)
		ASCH_ASC-1_like	434..547	CDD:119346	57/113 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152715
Domainoid	1	1.000	115	1.000	Domainoid score	I6045
eggNOG	1	0.900	-	-		E1_KOG2845
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9426
Inparanoid	1	1.050	309	1.000	Inparanoid score	I2610
Isobase	1	0.950	-	0	Normalized mean entropy	S5861
OMA	1	1.010	-	-		QHG56537
OrthoDB	1	1.010	-	-		D1132270at2759
OrthoFinder	1	1.000	-	-		FOG0004371
OrthoInspector	1	1.000	-	-		oto88366
orthoMCL	1	0.900	-	-		OOG6_103387
Panther	1	1.100	-	-	LDO	PTHR12963
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1813
SonicParanoid	1	1.000	-	-		X3093
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750