DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11710 and trip4

DIOPT Version :9

Sequence 1:	NP_001285492.1	Gene:	CG11710 / 33044	FlyBaseID:	FBgn0031115	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_001071043.2	Gene:	trip4 / 568585	ZFINID:	ZDB-GENE-040724-92	Length:	564	Species:	Danio rerio

Alignment Length:	575	Identity:	217/575 - (37%)
Similarity:	313/575 - (54%)	Gaps:	84/575 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ENFLRGTLSKC-----LDCVITDQMLAAILNIKDDYEFDNYFGNLLSEDNEEHRMFLVN------ 55
            ::.||.|:.|.     ||.  :|.::..||:|.:..|...|.|:|| :..|.::...|:
Zfish     3 DSLLRWTVDKLKHGFGLDA--SDDIVQYILSIDNADEIVEYVGDLL-QGTEGNKQEFVDELVQRW 64

  Fly    56 --CRRMLLSG--------------------------KQPRNNGKYLSPPLAPTSP--------NC 84
              |:.....|                          ::.||..:.::...|...|        ..
Zfish    65 QRCQTQTSDGLGGVLRKEVVMEELDTAPKDTQKKSKRKGRNKQEIVTVSQAEPEPVRTPIDLMKA 129

  Fly    85 PKQNISKGAKGKSGKHVNLYASDGRVQGD--TIILKGRRHCDCQAGQHKLINNCLGCGRIVCEQE 147
            .:.:.|...|.|| |.|||||.:|:   |  .::|.||:.|:|.|.:|:||||||.|||||||||
Zfish   130 QESSNSSSVKKKS-KFVNLYAKEGK---DKLAVLLPGRQACECLAQKHRLINNCLSCGRIVCEQE 190

  Fly   148 GSGPCLSCGDPVRTPEEE----------QQLAKAAREKGGTKSAAKQGKKSTKELSTQALDKALA 202
            ||||||.||..|.|.||:          |:|.|....:|..:......:...|    ..|:||:.
Zfish   191 GSGPCLFCGSLVCTNEEQEILQRDSNKSQKLRKKLMGEGTEREYLPHQESKMK----AGLEKAVK 251

  Fly   203 QRDRLLEYDKNSEKRTTVIDDELDYF-QENSVWLSDAEREKFEKLHREMEEVKHGSRMKRKIRVD 266
            .:|:|||:||||.|||.|:|||.||| .:::.|||..|||...|...|:.|::|.||..|||.:|
Zfish   252 HKDKLLEFDKNSVKRTQVLDDESDYFATDSNQWLSPGEREALRKREEELRELRHASRKDRKITLD 316

  Fly   267 FAGRELPEEPTISKEYEQQVISELAAVSKAS-GVGSNWSASSVTGHSALTLAPHLNMTKP----- 325
            ||||.:.:|......|.|:....:.|::..| |..:..||.:...|....:.|::..:.|
Zfish   317 FAGRRVLDEGENLSPYYQKFDETVKAINTGSFGQKAKHSAPADRQHFRELVNPNILQSAPEWVDV 381

  Fly   326 PVYKPSKESKSWPAPAAGSDWLERTYNRVQDKELLEMQDMRQCLSMHQPWASLLVAGIKKHEGRV 390
            ....||::|.|  ..|:|.:..||:..|:|||||.|:.|...|||||||||||||.|||:.|||.
Zfish   382 ASSNPSRKSSS--KAASGKETSERSRLRLQDKELQEIADGGWCLSMHQPWASLLVKGIKRVEGRT 444

  Fly   391 WYSEHRGRLWIASTSKEPHAEDIAQMEGFYKVLY-GDPDIKFPSHYPTSSLLGCVHVDSCLPQEE 454
            ||:.||||||||:.:..|..::||::|..|:.|| .:|  :||:.|||..|||||:|..||.||:
Zfish   445 WYTSHRGRLWIAAAANRPTPQEIAEVEAMYRHLYKHEP--QFPAEYPTGCLLGCVNVSDCLSQEQ 507

  Fly   455 YRELYP--NGESESPYVFVCTKPEQLNILLPVHGDHKIYELPLKTHTAACKTLLR 507
            :||.||  :.||.||:||:|:.|::|.:..|:.|.|||::|..::|.:|.|.|::
Zfish   508 FREQYPQISEESTSPFVFICSNPQELVVKFPMKGKHKIWKLESQSHQSAKKCLMQ 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11710	NP_001285492.1	zf-C2HC5	120..168	CDD:283802	33/57 (58%)
CG11710	NP_001285492.1	ASCH_ASC-1_like	367..478	CDD:119346	64/113 (57%)
trip4	NP_001071043.2	zf-C2HC5	163..211	CDD:283802	32/47 (68%)
trip4	NP_001071043.2	ASCH_ASC-1_like	420..533	CDD:119346	64/114 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587206
Domainoid	1	1.000	120	1.000	Domainoid score	I5739
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9426
Inparanoid	1	1.050	340	1.000	Inparanoid score	I2329
OMA	1	1.010	-	-		QHG56537
OrthoDB	1	1.010	-	-		D1132270at2759
OrthoFinder	1	1.000	-	-		FOG0004371
OrthoInspector	1	1.000	-	-		oto40810
orthoMCL	1	0.900	-	-		OOG6_103387
Panther	1	1.100	-	-	LDO	PTHR12963
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3093
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910