DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11710 and AgaP_AGAP000554

DIOPT Version :9

Sequence 1:	NP_001285492.1	Gene:	CG11710 / 33044	FlyBaseID:	FBgn0031115	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	XP_310529.5	Gene:	AgaP_AGAP000554 / 1271670	VectorBaseID:	AGAP000554	Length:	557	Species:	Anopheles gambiae

Alignment Length:	565	Identity:	252/565 - (44%)
Similarity:	336/565 - (59%)	Gaps:	65/565 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MENFLRGTLSKCLDCVITDQMLAAILNIKDDYEFDNYFGNLLSEDNEEHRMFLVNCR-------- 57
            |..:::..|||||...|.|.::|.|..|::.:|.|.||..||..:|.:|..|:...:
Mosquito     1 MNQWIKEELSKCLHFDIPDDLIAYIHTIQNAHEIDGYFRTLLDYNNPQHTAFIRELKVRLGHDTP 65

  Fly    58 ------RMLLSGKQPRNNGKYLSPPLA--------------PTSPNCPKQNISK----------- 91
                  :.|.:||   :.||....|.|              |:..|.|....|.
Mosquito    66 DGLPVMKPLTTGK---SAGKSKQQPSASSSKQQQQQQQQTKPSKANPPTSGASSSKPTPTAPEAS 127

  Fly    92 ----GAKGKSGKHVNLYASDGRVQGDTIILKGRRHCDCQAGQHKLINNCLGCGRIVCEQEGSGPC 152
                |...|..|:||||..||.: .|.::||||.|||||||:|:|:||||.||||||||||||||
Mosquito   128 GGGGGGSKKKTKYVNLYGQDGEL-ADVVLLKGRHHCDCQAGKHRLVNNCLHCGRIVCEQEGSGPC 191

  Fly   153 LSCGDPVRTPEEEQQLAKAAREKGGT--KSAAKQGKKSTKELSTQALDKALAQRDRLLEYDKNSE 215
            |.||..|.| |.||:|.::|..||.:  ::..:|.:.:       ..::|||.|:||||||:|||
Mosquito   192 LFCGSLVCT-EHEQRLIESASRKGDSLRRTLMEQNRPA-------GWEEALATRNRLLEYDRNSE 248

  Fly   216 KRTTVIDDELDYFQENSVWLSDAEREKFEKLHREMEEVKHGSRMKRKIRVDFAGRELPEEPTISK 280
            |||||||||.|||:.:|||||||||:|.|:|..|:.|.:|.||:.||:.:|||||.:.:|..:|.
Mosquito   249 KRTTVIDDEADYFKTHSVWLSDAERKKLEQLEEELREKRHASRLARKVTLDFAGRRVLDEAALST 313

  Fly   281 EYEQQVISELAAV-SKASGVGSNWS-----ASSVTGHSALTLAPHLNMTKPPVYKPSKESKSWPA 339
            |..::::.:.:.| :..||.|....     ....||..:..:.|.|:...|.....:..:.:...
Mosquito   314 EDVEEILRQASLVEAPVSGGGRGKENVQPPGQHPTGPDSEDVHPTLSGPAPTFVDVNAGAPAAGR 378

  Fly   340 PAAGSDWLERTYNRVQDKELLEMQDMRQCLSMHQPWASLLVAGIKKHEGRVWYSEHRGRLWIAST 404
            ||..:...:..|:||||||.|:|.|:|.|||||||||||||||||:||||.|||.||||||||:|
Mosquito   379 PAISTTGYDGVYSRVQDKEFLQMSDLRHCLSMHQPWASLLVAGIKRHEGRTWYSSHRGRLWIAAT 443

  Fly   405 SKEPHAEDIAQMEGFYKVLYGD-PDIKFPSHYPTSSLLGCVHVDSCLPQEEYRELYPNGESESPY 468
            :|....|.|.::|.||:.|||| .:::||:.||...|||||.|..||||||||:.:|||||:||:
Mosquito   444 AKPADPETIRELECFYRTLYGDGAELQFPTQYPAGCLLGCVSVQDCLPQEEYRKQHPNGESDSPF 508

  Fly   469 VFVCTKPEQLNILLPVHGDHKIYELPLKTHTAACKTLLR-ARANK 512
            ||||.:|::|.|..||.||||||.|....|.||.|.|.| |:.||
Mosquito   509 VFVCEEPQELPIRFPVRGDHKIYMLDSGIHQAAVKALQRLAKQNK 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11710	NP_001285492.1	zf-C2HC5	120..168	CDD:283802	36/47 (77%)
CG11710	NP_001285492.1	ASCH_ASC-1_like	367..478	CDD:119346	73/111 (66%)
AgaP_AGAP000554	XP_310529.5	zf-C2HC5	162..207	CDD:283802	34/45 (76%)
AgaP_AGAP000554	XP_310529.5	ASCH_ASC-1_like	407..518	CDD:119346	73/110 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	141	1.000	Domainoid score	I9693
eggNOG	1	0.900	-	-		E1_KOG2845
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9426
Inparanoid	1	1.050	449	1.000	Inparanoid score	I3481
OMA	1	1.010	-	-		QHG56537
OrthoDB	1	1.010	-	-		D1132270at2759
OrthoFinder	1	1.000	-	-		FOG0004371
OrthoInspector	1	1.000	-	-		oto105740
Panther	1	1.100	-	-	LDO	PTHR12963
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3093
TreeFam	1	0.960	-	-
	13	12.940