DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11710 and trip4

DIOPT Version :9

Sequence 1:	NP_001285492.1	Gene:	CG11710 / 33044	FlyBaseID:	FBgn0031115	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	XP_012821544.2	Gene:	trip4 / 100145534	XenbaseID:	XB-GENE-974186	Length:	593	Species:	Xenopus tropicalis

Alignment Length:	569	Identity:	218/569 - (38%)
Similarity:	308/569 - (54%)	Gaps:	87/569 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LSKCLDCVITDQMLAAILNIKDDYEFDNYFGNLLSEDNEEHRMF--------------------- 52
            |.|.....:::.::..||:|..:.|.|.|..:|:....:...:|
Frog    34 LEKRFGLGVSEDVVKYILSIDKEEEIDEYINDLVQAPEDTKSLFTRELKLRWHRIRQPPASRTTS 98

  Fly    53 ---------LVNCRRMLL--SGKQPRNNGKYLSPPLA---PTSPNCPKQ-----NISK------- 91
                     :....::|.  .|||.|..|:....||.   |||....::     :::|
Frog    99 AFQRKDGAEVFQTDKLLFGEQGKQRRRKGRNKMEPLQAVYPTSNTSAEEVKTPMDLAKAQEVVGL 163

  Fly    92 GAKGKSGKHVNLYASDGRVQGD--TIILKGRRHCDCQAGQHKLINNCLGCGRIVCEQEGSGPCLS 154
            .:..|..|.||||..:|:   |  |:::.||..|:|.|.:|:|||||:.||||||||||||||:.
Frog   164 SSSKKKQKFVNLYTKEGQ---DRLTVLIPGRYPCECLAQKHRLINNCMTCGRIVCEQEGSGPCMF 225

  Fly   155 CGDPVRTPEEEQQLAKAAREKGGTKSAAKQ--GKKSTKEL-------STQALDKALAQRDRLLEY 210
            ||..|.|.||   |....|:...::...|:  |.:|.|:|       ..:.|:|||..|::||||
Frog   226 CGSLVCTKEE---LDILQRDSNKSQKLRKKLLGSESAKDLLPHQEIKMKEGLEKALQHRNKLLEY 287

  Fly   211 DKNSEKRTTVIDDELDYFQ-ENSVWLSDAEREKFEKLHREMEEVKHGSRMKRKIRVDFAGRELPE 274
            ||.|.:||.|||||.|||. :::.|||..|||...|..:|::|::|.||:.||..:|||||::.|
Frog   288 DKTSVRRTQVIDDESDYFSTDSNQWLSQTERETLRKKEQELQELRHASRLSRKFTIDFAGRKVFE 352

  Fly   275 EPTISKEYEQ------QVISELAAVSKASGVGSNWSASSVTGHSALTLAPHLNMTKP-PVYKPSK 332
            |....|||.:      |.|.....|..:...|...:.||:...|.|         :| ||:....
Frog   353 EGEDLKEYNKLLDETVQSIHSGTVVFPSGSPGERSNTSSLVNPSLL---------QPSPVWVDQV 408

  Fly   333 ESKSWPAPAAGSD---WLERTYNRVQDKELLEMQDMRQCLSMHQPWASLLVAGIKKHEGRVWYSE 394
            .|.|:...|:..:   ..||...|:||:||.|:.|:..|||||||||||||||||:.|||.|||.
Frog   409 SSGSYKKKASSEETKPCTERNRLRIQDRELQEISDLGMCLSMHQPWASLLVAGIKQVEGRTWYSA 473

  Fly   395 HRGRLWIASTSKEPHAEDIAQMEGFYKVLYGDPDIKFPSHYPTSSLLGCVHVDSCLPQEEYRELY 459
            ||||||||:.||.|..::|:::|..|:||. ..||.||..||||.|||||.|:.|:.||:::|.|
Frog   474 HRGRLWIAAASKRPSPQEISELETSYRVLL-QKDIHFPKDYPTSCLLGCVDVNDCVSQEQFKEQY 537

  Fly   460 P--NGESESPYVFVCTKPEQLNILLPVHGDHKIYELPLKTHTAACKTLL 506
            |  |.||.||::|:|:.|::|.|..|:.|.|||::|..|.|..|.|.|:
Frog   538 PNLNQESASPFIFICSNPQELLIKFPIKGQHKIWKLDSKIHQGAKKGLM 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11710	NP_001285492.1	zf-C2HC5	120..168	CDD:283802	30/47 (64%)
CG11710	NP_001285492.1	ASCH_ASC-1_like	367..478	CDD:119346	67/112 (60%)
trip4	XP_012821544.2	zf-C2HC5	191..239	CDD:399315	31/50 (62%)
trip4	XP_012821544.2	ASCH_ASC-1_like	445..558	CDD:119346	67/113 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5672
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	336	1.000	Inparanoid score	I2347
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132270at2759
OrthoFinder	1	1.000	-	-		FOG0004371
OrthoInspector	1	1.000	-	-		oto102250
Panther	1	1.100	-	-	LDO	PTHR12963
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1813
SonicParanoid	1	1.000	-	-		X3093
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.190