DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cactin and AT1G03910

DIOPT Version :9

Sequence 1:	NP_523422.4	Gene:	cactin / 33043	FlyBaseID:	FBgn0031114	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001184904.1	Gene:	AT1G03910 / 839371	AraportID:	AT1G03910	Length:	716	Species:	Arabidopsis thaliana

Alignment Length:	798	Identity:	267/798 - (33%)
Similarity:	404/798 - (50%)	Gaps:	173/798 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SRSRERRDHRSPDPRSSRNRDRDRERER-------EKDRDHRDHRDKERDQRREREKDKSRDKKR 69
            |..:.:||      ||.|.:.|..|.|.       ..|.|..|.....|..||::.....|
plant     3 SHGKGKRD------RSGRQKKRRDESESGSESESYTSDSDGSDDLSPPRSSRRKKGSSSRR---- 57

  Fly    70 EHKSRRRRSSSSSSSPSSSTSSSVPGAPRSPLVKSPMKLLQTLEARRLVEQKDRQRK-KEELKAH 133
                .||||||..||.|                                   |..|| |:...:.
plant    58 ----TRRRSSSDDSSDS-----------------------------------DGGRKSKKRSSSK 83

  Fly   134 ETPEEKRARRLREKQAKEQRRRERMGWDNEYQTYSNEDNPFGDSNLTSTFHWGKKLEVE-----G 193
            :..|||....:.:|..|:..|..:.........|||:.|||||||||.||.|.||:|.:     .
plant    84 DYSEEKVTEYMSKKAQKKALRAAKKLKTQSVSGYSNDSNPFGDSNLTETFVWRKKIEKDVHRGVP 148

  Fly   194 LSNLSTKTVEVLSLQKQLENRRELEKVKKRRQERELERQVREDDLMMQQRAKEAVQFREWQRQED 258
            |...|.|..:    ::..|...|:|||||||:||.:|:...|:::.:..|.:...:|.:|:::|:
plant   149 LEEFSVKAEK----RRHRERMTEVEKVKKRREERAVEKARHEEEMALLARERARAEFHDWEKKEE 209

  Fly   259 QFHLEQARLRSEIRIRDGRAKPIDLLAQYVAAGNEPLEECLEMQMHEPY---------------- 307
            :||.:|:::|||||:|:||.||||:|.:::...::     |::::.|||
plant   210 EFHFDQSKVRSEIRLREGRLKPIDVLCKHLDGSDD-----LDIELSEPYMVFKKKKVRIGIWLNF 269

  Fly   308 ---------------------------VLLN-GLPVEELEDLLVDIKVYEELEQG--KHIDFWND 342
                                       :||| ||.|:::|:|..|||:|.:|::.  ..:.:|..
plant   270 QLSITNVYVEAEYKNDSACLLLRSRVDILLNKGLTVKDMEELRDDIKMYLDLDRATPTRVQYWEA 334

  Fly   343 MITIVQDELQRQQKLEAENSS-----------LNQRRDGIHQAVVKDVADIFRGKNAQQLEEMRH 396
            :|.:...||...:|.:|.:.:           |.|.| |:|..|..||..:..||...:|.|::.
plant   335 LIVVCDWELAEARKRDALDRARVRGEEPPAELLAQER-GLHAGVEADVRKLLDGKTHAELVELQL 398

  Fly   397 RIEAKI-SGRADGVDISYWESLLSQLKAHMARARLRDRHQALLREKLSLLKRENDNETLQEKVAP 460
            .||::: ||.|..|:  |||::|.:|:.:.|:|.|::.|..:||..|..|::.::.|. ..:|.|
plant   399 DIESQLRSGSAKVVE--YWEAVLKRLEIYKAKACLKEIHAEMLRRHLHRLEQLSEGED-DVEVNP 460

  Fly   461 ----QVKEEEMETQDAEDPEVEEG-SPED--EEDPLNELRKTVRLYQAGNYSPRYIREEDFTGRR 518
                .|:|.|.|..|....:.||. |||.  ||:..:|..:.     ||::||..:..:|
plant   461 GLTRVVEENEEEINDTNLSDAEEAFSPEPVAEEEEADEAAEA-----AGSFSPELMHGDD----- 515

  Fly   519 AQNEDVDEPEAEGLLYEEEDDERRTQRQRLLILHPER-----VDNNQLTPQELRMRNEAKQGM-- 576
              .|:..:|         |:|::..|.:|:::|..::     ..:::..|.|..:..:|.:.|
plant   516 --REEAIDP---------EEDKKLLQMKRMIVLEKQKKRLKEAMDSKPAPVEDNLELKAMKAMGA 569

  Fly   577 --QGDEAEF--SVETTLDAVPQLATDKYRPRKPRYFNRVHTGFEWNKYNQTHYDMDNPPPKIVQG 637
              :|| |.|  :.|..||:......||||||||:||||||||:|||||||||||.||||||||||
plant   570 MEEGD-AIFGSNAEVNLDSEVYWWHDKYRPRKPKYFNRVHTGYEWNKYNQTHYDHDNPPPKIVQG 633

  Fly   638 YKFNIFYPDLMDKSQTPQYFLTPCADNGDFAVLRFHTGPPYEDIAFKIVNREWEFSYKRGFRCQF 702
            ||||||||||:||.:.|.|.:.....:.:..::|||.|||||||||:|||:|||:|:|:||:|.|
plant   634 YKFNIFYPDLVDKIKAPIYTIEKDGTSAETCMIRFHAGPPYEDIAFRIVNKEWEYSHKKGFKCTF 698

  Fly   703 HNNIFQLWFHFKRYRYRR 720
            ...|..|:|:|||:||||
plant   699 ERGILHLYFNFKRHRYRR 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cactin	NP_523422.4	Endonuc_Holl	202..>274	CDD:295105	25/71 (35%)
		Cactin_mid	243..432	CDD:287304	69/246 (28%)
		CactinC_cactus	598..720	CDD:286775	83/121 (69%)
AT1G03910	NP_001184904.1	Cactin_mid	194..433	CDD:287304	69/246 (28%)
AT1G03910	NP_001184904.1	CactinC_cactus	592..716	CDD:286775	83/123 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	202	1.000	Domainoid score	I858
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69553
Inparanoid	1	1.050	391	1.000	Inparanoid score	I495
OMA	1	1.010	-	-		QHG54753
OrthoDB	1	1.010	-	-		D1252926at2759
OrthoFinder	1	1.000	-	-		FOG0005003
OrthoInspector	1	1.000	-	-		oto4091
orthoMCL	1	0.900	-	-		OOG6_102945
Panther	1	1.100	-	-	LDO	PTHR21737
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4073
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.980