DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cactin and CACTIN

DIOPT Version :9

Sequence 1:NP_523422.4 Gene:cactin / 33043 FlyBaseID:FBgn0031114 Length:720 Species:Drosophila melanogaster
Sequence 2:NP_001074012.1 Gene:CACTIN / 58509 HGNCID:29938 Length:758 Species:Homo sapiens


Alignment Length:781 Identity:372/781 - (47%)
Similarity:486/781 - (62%) Gaps:105/781 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 KEKSKHRHRSRSRERRDHRSPDPRSSRNRDRDREREREKDRDHRDHRDKERDQR---RER----- 59
            :.:|..|.||||..||:.|       |..|..|.|.|.:.|:.|...::||.||   |.|     
Human    20 QSQSGSRSRSRSHGRRNRR-------RREDEGRRRRRRRSRERRSDSEEERWQRSGMRSRSPPRP 77

  Fly    60 ---------EKDKSRDKKREHKSRRRRSSSSSSSPSSSTSSSVPGAPRSPLVKSPMKLLQTLEAR 115
                     :.|...::.|...:||||.:.|.|..||::||:.||..:||...:.....|.....
Human    78 KWHSRDGSSQSDSGEEQSRGQWARRRRRARSWSPSSSASSSASPGRSQSPRAAAAALSQQQSLQE 142

  Fly   116 RLVEQKDRQRKKEELKAHETPEEKRARRLREKQAKEQRRRERMGWDNEYQTYSNEDNPFGDSNLT 180
            ||..:::|::::|.:||.|||||||||||.:|:|||:::||:|||..||..|:|.||||||:||.
Human   143 RLRLREERKQQEELMKAFETPEEKRARRLAKKEAKERKKREKMGWGEEYMGYTNTDNPFGDNNLL 207

  Fly   181 STFHWGKKLEVEGLSNLSTKTVEVLSLQKQLENRRELEKVKKRRQERELERQVREDDLMMQQRAK 245
            .||.|.|.||.:|:|:|..|.::..:.:.|.:||.||:|||:.|.|||.|:.:||.:|.|.||.|
Human   208 GTFIWNKALEKKGISHLEEKELKERNKRIQEDNRLELQKVKQLRLEREREKAMREQELEMLQREK 272

  Fly   246 EAVQFREWQRQEDQFHLEQARLRSEIRIRDGRAKPIDLLAQYVAAGNEPLEECLEMQMHEPYVLL 310
            ||..|:.|:.|||.|||:||:|||:|||||||||||||||:|::|.::.    |.::|||||..|
Human   273 EAEHFKTWEEQEDNFHLQQAKLRSKIRIRDGRAKPIDLLAKYISAEDDD----LAVEMHEPYTFL 333

  Fly   311 NGLPVEELEDLLVDIKVYEELEQGKHIDFWNDMITIVQDELQRQQKLEAENSSLNQRRDGIHQAV 375
            |||.|.::||||.||:||.||||||:.|||.||.||.:||:.:.:||||......:||:|::.:|
Human   334 NGLTVADMEDLLEDIQVYMELEQGKNADFWRDMTTITEDEISKLRKLEASGKGPGERREGVNASV 398

  Fly   376 VKDVADIFRGKNAQQLEEMRHRIEAKISGRADGVDISYWESLLSQLKAHMARARLRDRHQALLRE 440
            ..||..:|:||...||:.:...||.||......:|:.||||||.||:|||||||||:|||.:||:
Human   399 SSDVQSVFKGKTYNQLQVIFQGIEGKIRAGGPNLDMGYWESLLQQLRAHMARARLRERHQDVLRQ 463

  Fly   441 KLSLLKRENDNETLQEKVAPQVKEE------EMETQDA-------------EDPEVE-------- 478
            ||..||:|...|:  |.:.|.:|:|      .:|.:||             .:.||:        
Human   464 KLYKLKQEQGVES--EPLFPILKQEPQSPSRSLEPEDAAPTPPGPSSEGGPAEAEVDGATPTEGD 526

  Fly   479 -----EGSPEDEEDPLNE--LRKTVRLYQAGNYSPRYIREEDFTGRRAQNEDVDEPEAEGLLYEE 536
                 ||..|.|...:.|  :::::..|.||.||||.:...:.            |....:|..:
Human   527 GDGDGEGEGEGEAVLMEEDLIQQSLDDYDAGRYSPRLLTAHEL------------PLDAHVLEPD 579

  Fly   537 EDDERRTQRQRLLILHPERVDNNQLTPQELRMRNE------------AKQGMQGDEAEFSVETTL 589
            ||      .|||           ||:.|:|::..:            ||:||..|||:||||..|
Human   580 ED------LQRL-----------QLSRQQLQVTGDASESAEDIFFRRAKEGMGQDEAQFSVEMPL 627

  Fly   590 DAVPQLATDKYRPRKPRYFNRVHTGFEWNKYNQTHYDMDNPPPKIVQGYKFNIFYPDLMDKSQTP 654
            .....|..|||||||||:|||||||||||||||||||.||||||||||||||||||||:||..||
Human   628 TGKAYLWADKYRPRKPRFFNRVHTGFEWNKYNQTHYDFDNPPPKIVQGYKFNIFYPDLIDKRSTP 692

  Fly   655 QYFLTPCADNGDFAVLRFHTGPPYEDIAFKIVNREWEFSYKRGFRCQFHNNIFQLWFHFKRYRYR 719
            :|||..||||.|||:||||.|||||||||||||||||:|::.||||||.|.||||||||||||||
Human   693 EYFLEACADNKDFAILRFHAGPPYEDIAFKIVNREWEYSHRHGFRCQFANGIFQLWFHFKRYRYR 757

  Fly   720 R 720
            |
Human   758 R 758

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cactinNP_523422.4 Endonuc_Holl 202..>274 CDD:295105 37/71 (52%)
Cactin_mid 243..432 CDD:287304 104/188 (55%)
CactinC_cactus 598..720 CDD:286775 104/121 (86%)
CACTINNP_001074012.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..140 39/126 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 155..181 18/25 (72%)
PaaSYMP <213..304 CDD:291408 47/90 (52%)
Cactin_mid 270..455 CDD:287304 104/188 (55%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 477..536 11/58 (19%)
CactinC_cactus 634..758 CDD:286775 104/123 (85%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165160527
Domainoid 1 1.000 247 1.000 Domainoid score I2166
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H69553
Inparanoid 1 1.050 668 1.000 Inparanoid score I754
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54753
OrthoDB 1 1.010 - - D1252926at2759
OrthoFinder 1 1.000 - - FOG0005003
OrthoInspector 1 1.000 - - oto90713
orthoMCL 1 0.900 - - OOG6_102945
Panther 1 1.100 - - LDO PTHR21737
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1715
SonicParanoid 1 1.000 - - X4073
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1413.940

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