DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cactin and SPBC2F12.12c

DIOPT Version :9

Sequence 1:	NP_523422.4	Gene:	cactin / 33043	FlyBaseID:	FBgn0031114	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_595704.1	Gene:	SPBC2F12.12c / 2540353	PomBaseID:	SPBC2F12.12c	Length:	517	Species:	Schizosaccharomyces pombe

Alignment Length:	556	Identity:	160/556 - (28%)
Similarity:	257/556 - (46%)	Gaps:	107/556 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 SLQKQLENRR---ELEKVKKRRQERELERQVREDDLMMQQRAKEAVQFREWQRQEDQFHLEQARL 267
            |.:...:|.|   .|.:|:...:|.|..|:.:|            :|.||:.|      |:|.|
pombe    28 SFRPSNQNARANYNLPRVRDAMKEEERSRETKE------------MQEREFLR------LQQLR- 73

  Fly   268 RSEIRIRDGRAKPID--LLAQYVAAGNEPLEECLE--------MQMHEPYVLLNGLPVEELEDLL 322
            |:.||:::.|:||||  |::.|:..|.| .||..|        :.|.:|..::.....|:||::.
pombe    74 RAIIRLKNDRSKPIDKLLVSVYLMPGPE-WEENGEKNSIDFGTVDMFDPLSVIQSYKAEDLEEIS 137

  Fly   323 VDIKVYEELEQGK-HIDFWNDMITIVQDELQRQQKLEAENSSLNQRRDGIHQAVVKDVADIFRGK 386
            .:|...::||..: .:.:|..:..:|...:        |::.:.|...|: :.|..:|..|...|
pombe   138 RNIGDIQQLETNQCRLTYWKYVKMLVNSRM--------EHNKVGQFSRGL-KVVAGEVQRILAPK 193

  Fly   387 NAQQLEEMRHRIEAKISGRADGVDISYWESLLSQLKAHMARARLRDRHQALLREKLSLLKRENDN 451
            :.:|||::..:|:.|:..... :|..||..||:.||::.|.|.|:    ....|:|.:.|.:.||
pombe   194 SFEQLEQLEAQIQKKLKSNVP-LDTDYWVDLLNSLKSYKAIAYLK----KTFNEELQIRKNKLDN 253

  Fly   452 ETLQEKVAPQVKEEEMETQDAE------DPE--------VEEGSPEDEEDPLNELRKTVRLYQAG 502
            |...:..:...|...|:.::.:      ||:        .....||::.|...||...|.:.::.
pombe   254 EEWDKAFSDAKKLSNMKDREEKLYIVPIDPKPILRAQAIPRRIQPEEQADYEKELNDHVNIVKSS 318

  Fly   503 NYSPRYIREEDFTGRRAQNEDVDEPEAEGLLYEEEDDERRTQRQRLLILHPERVDNNQLTPQELR 567
            .|.|..|        ..|.:....|:...|:  .||:.....|.||     ||        :.|:
pombe   319 TYIPISI--------PTQKQKPTLPKNSNLI--NEDEFSIANRARL-----ER--------EYLQ 360

  Fly   568 MRNEAKQGMQGDEAEFSVETTLDAVPQLATDKYRPRKPRYFNRVHTGFEWNKYNQTHYDMDNPPP 632
            ..:..:|.|.||..|.......:....|       :||.|||||..|||||.|||.|::..:|||
pombe   361 SDDAEEQEMLGDYVEGQTRVVNENGVTL-------KKPHYFNRVLLGFEWNSYNQAHFNEAHPPP 418

  Fly   633 KIVQGYKFNIFYPDLMDKSQTPQYFL-----------TPCADNGDFAVLRFHTGPPYEDIAFKIV 686
            |.||||:||:|||||:...:.|.|.:           |...|  |..::||..|.||:||||.||
pombe   419 KAVQGYRFNVFYPDLIGTGRAPTYRIERTRRKNKSDTTDLQD--DVCIIRFIAGEPYQDIAFSIV 481

  Fly   687 NREWEFSYKR--GFRCQFHNNIFQLWFHFKRYRYRR 720
            :::|::|.||  ||:..|.|.:..|.|.||:..:||
pombe   482 DKDWDYSAKRDHGFKSSFDNGVLSLHFRFKKLHHRR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cactin	NP_523422.4	Endonuc_Holl	202..>274	CDD:295105	19/70 (27%)
		Cactin_mid	243..432	CDD:287304	54/199 (27%)
		CactinC_cactus	598..720	CDD:286775	59/134 (44%)
SPBC2F12.12c	NP_595704.1	Cactin_mid	49..238	CDD:287304	58/222 (26%)
		SPATA9	<229..>262	CDD:292452	9/36 (25%)
		CactinC_cactus	383..517	CDD:286775	60/142 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	129	1.000	Domainoid score	I1346
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	184	1.000	Inparanoid score	I1100
OMA	1	1.010	-	-		QHG54753
OrthoFinder	1	1.000	-	-		FOG0005003
OrthoInspector	1	1.000	-	-		oto101639
orthoMCL	1	0.900	-	-		OOG6_102945
Panther	1	1.100	-	-	LDO	PTHR21737
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1715
SonicParanoid	1	1.000	-	-		X4073
TreeFam	0	0.000	Not matched by this tool.
	11	11.000