DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cactin and cacn-1

DIOPT Version :9

Sequence 1:	NP_523422.4	Gene:	cactin / 33043	FlyBaseID:	FBgn0031114	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	NP_001254422.1	Gene:	cacn-1 / 175066	WormBaseID:	WBGene00012230	Length:	657	Species:	Caenorhabditis elegans

Alignment Length:	713	Identity:	272/713 - (38%)
Similarity:	391/713 - (54%)	Gaps:	115/713 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 RDKKREHKSRRRRSSSSSSSPSSSTSSSVPGAPRSPLVKSPMKLLQTLEARRLVEQKDRQRKKEE 129
            :|.|: ||..|||..|.|:|.|...                 :|.:.|..:|.:::.:::|:|||
Worm     3 KDSKK-HKKERRRERSPSTSDSDEE-----------------RLQKRLAEQRSLKKDEKRRQKEE 49

  Fly   130 LKAHETPEEKRARRLREKQAKEQRRRERMGWDN---EYQTYSNEDNPFGDSNLTSTFHWGKKLEV 191
            :|.:|:.|||||||:.:|..|:.:|::....|.   ....|:|.:|||.|:.||.||.||||||.
Worm    50 MKKNESAEEKRARRMEKKMRKDAKRKDADAEDTLIPPELNYTNLNNPFNDTKLTQTFVWGKKLER 114

  Fly   192 EGLSNLSTKTVEVLSLQKQLENRRELEKVKKRRQER-----ELERQVREDDLMMQQRAKEAVQFR 251
            ||.|.|:...:...:.|:..:|..|..:.|:.|..|     ::|...|:.||...|.:
Worm   115 EGKSGLTQDEITKQTSQRIRKNLHEAAEFKRIRDSRAAAKEDMEMMKRDADLRAGQIS------- 172

  Fly   252 EWQRQEDQFHLEQARLRSEIRIRDGRAKPIDLLAQYV--AAGNEPLEECLEMQMHEP--YVLLNG 312
              ..:|.:|.::|.:.|:.|||..||||.||||::|.  |..|....:..:.::..|  |:..:.
Worm   173 --DTKEREFQMDQIKERTRIRIDQGRAKAIDLLSRYARFADENPHTAKIPDFELENPMEYLKASC 235

  Fly   313 LPVEELEDLLVDIKVYEELE-QGKHIDFWNDMITIVQDELQRQQKLEAENSSLNQRRDGIHQAVV 376
            ..|::.|||:.|||.|.|:: ..|:..:|.|:..|.:||:|::..         |.|..:|.:|.
Worm   236 KSVDDYEDLIEDIKTYREVDGWAKNETWWMDVTRIAEDEIQKKAA---------QNRGDVHASVQ 291

  Fly   377 KDVADIFRGKNAQQLEEMRHRIEAKISGRADGVDISYWESLLSQLKAHMARARLRDRHQALLREK 441
            .:|.::|:.|:..:|.::..:::|||.|.:.  :..||:.|..|||..:||.|||:.|..:||.:
Worm   292 TEVQNMFKNKSIDELLKLEDQMDAKIRGNSG--NKGYWQDLDDQLKVFIARKRLREHHGRVLRLQ 354

  Fly   442 LSLLKRENDNETLQE---------KVAPQVK------EEEMETQDAE----------------DP 475
            |:::|.|...|..|:         :|.||||      |||.|.:|.|                ||
Worm   355 LAIIKEEQKKEIQQQESEELLPVAEVPPQVKIQKEEEEEEEEDEDDEKISKKVRRKIDVQTLDDP 419

  Fly   476 EVEEGSPEDEE-------DPLNELRKTVRLYQAGNYSPRYIREEDFTGRRAQNEDVDEPEAEGLL 533
            |::|  ||.|.       |.|:::  |..||:.|.|||.||..:|           ..|..| :|
Worm   420 ELDE--PERERKWRALTGDQLDDV--TRELYRIGCYSPTYISADD-----------TMPGIE-IL 468

  Fly   534 YEEED----DERRTQRQRLLILHPERVDNNQLTPQ--ELRMRNEAKQGMQGDEAEFSVETTLDAV 592
            .|:.|    .|||.:.:..|   |.....:...||  ..:|...|::||:.||:.|..|..|.|.
Worm   469 DEQADVDNLTERRNRNRGTL---PSSSAASSGAPQGASSKMMAIAREGMEADESIFGAEEQLAAQ 530

  Fly   593 PQLATDKYRPRKPRYFNRVHTGFEWNKYNQTHYDMDNPPPKIVQGYKFNIFYPDLMDKSQTPQYF 657
            ..|.:||||||||.|.|||.|||:||||||||||.||||||||||||||||||||:|.:..|::.
Worm   531 RHLWSDKYRPRKPTYLNRVQTGFDWNKYNQTHYDQDNPPPKIVQGYKFNIFYPDLLDMTVAPRFG 595

  Fly   658 LTPCADNGDFAVLRFHTGPPYEDIAFKIVNREWEFSYKRGFRCQFHNNIFQLWFHFKRYRYRR 720
            ||.|.| .|||::||..||||||||||:||||||..:|.|::|||.|.:|||||.||:|||||
Worm   596 LTSCED-PDFAIIRFKAGPPYEDIAFKVVNREWETLHKNGYKCQFQNGVFQLWFMFKKYRYRR 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cactin	NP_523422.4	Endonuc_Holl	202..>274	CDD:295105	17/76 (22%)
		Cactin_mid	243..432	CDD:287304	58/193 (30%)
		CactinC_cactus	598..720	CDD:286775	88/121 (73%)
cacn-1	NP_001254422.1	Cactin_mid	175..345	CDD:287304	58/180 (32%)
cacn-1	NP_001254422.1	CactinC_cactus	534..657	CDD:286775	88/123 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167999
Domainoid	1	1.000	210	1.000	Domainoid score	I1650
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69553
Inparanoid	1	1.050	425	1.000	Inparanoid score	I980
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54753
OrthoDB	1	1.010	-	-		D1252926at2759
OrthoFinder	1	1.000	-	-		FOG0005003
OrthoInspector	1	1.000	-	-		oto18097
orthoMCL	1	0.900	-	-		OOG6_102945
Panther	1	1.100	-	-	LDO	PTHR21737
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1715
SonicParanoid	1	1.000	-	-		X4073
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940