DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cactin and cactin

DIOPT Version :9

Sequence 1:	NP_523422.4	Gene:	cactin / 33043	FlyBaseID:	FBgn0031114	Length:	720	Species:	Drosophila melanogaster
Sequence 2:	XP_005168488.1	Gene:	cactin / 100126813	ZFINID:	ZDB-GENE-060503-322	Length:	836	Species:	Danio rerio

Alignment Length:	775	Identity:	382/775 - (49%)
Similarity:	481/775 - (62%)	Gaps:	102/775 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KSKHR----HRSRSRERRDHRSPDPRSSRNRD-----RDREREREKDRDHRDHRDKERDQRRERE 60
            |.||.    .|||.|:.|........|||.|:     |.|||||.:.:.....|::.|||||.|.
Zfish   105 KKKHNDEKDSRSRRRKSRSSSGSSTNSSRERNRSKTSRSRERERRRRQSRSSSRERHRDQRRRRN 169

  Fly    61 K-DKSRDKKREHKSRRRRSSSSSSSPSSSTSSSVPGAPRSPLVKSPMKLLQTLEARRLVEQKDRQ 124
            . ::.||::|..:|   ||||||||.|.....|..|...|.                  |:|.:|
Zfish   170 SPERDRDRRRRSQS---RSSSSSSSDSDHGGKSTQGGSSSK------------------EEKKKQ 213

  Fly   125 RKKEELKAHETPEEKRARRLREKQAKEQRRRERMGWDNEYQTYSNEDNPFGDSNLTSTFHWGKKL 189
            |  :.:||.|||||||||||.:|:|||:::||:|||..||..|:|.||||||:||..||.|.|.|
Zfish   214 R--DLMKALETPEEKRARRLAKKEAKERKKREKMGWSEEYMGYTNADNPFGDNNLLGTFIWQKAL 276

  Fly   190 EVEGLSNLSTKTVEVLSLQKQLENRRELEKVKKRRQERELERQVREDDLMMQQRAKEAVQFREWQ 254
            |.:|:.:||.|.::..:...|.||||||:|||:.|.|||.|:.:||.:|.|.||.|||..|:.|.
Zfish   277 EKKGIGHLSEKNLKDRNKHIQEENRRELQKVKQLRLEREREKAMREQELEMLQREKEAEHFKTWA 341

  Fly   255 RQEDQFHLEQARLRSEIRIRDGRAKPIDLLAQYVAAGNEPLEECLEMQMHEPYVLLNGLPVEELE 319
            .|||.|||.||:|||:|||||||||||||||:|::|.::.    |.::|||||..||||.|.::|
Zfish   342 EQEDNFHLHQAKLRSKIRIRDGRAKPIDLLAKYISAEDDD----LSVEMHEPYTFLNGLTVTDME 402

  Fly   320 DLLVDIKVYEELEQGKHIDFWNDMITIVQDELQRQQKLEAENSSLNQRRDGIHQAVVKDVADIFR 384
            |||.|||||.|||.||::|||.||.||.:||:.:.:||||.......||:||:.:|..||..:|:
Zfish   403 DLLEDIKVYMELECGKNVDFWRDMTTITEDEISKLRKLEASGKGPGDRREGINTSVSTDVQSVFK 467

  Fly   385 GKNAQQLEEMRHRIEAKISGRADGVDISYWESLLSQLKAHMARARLRDRHQALLREKLSLLKREN 449
            ||...||:.:...||:||......:||.||||||.|::.:|||||||:|||.:||:||..||:|.
Zfish   468 GKTYSQLQALYMNIESKIQAGGSNLDIGYWESLLQQVRVYMARARLRERHQDVLRQKLYKLKQEQ 532

  Fly   450 DNETLQEKVAPQVKEE-----EMETQDAEDPEVEEGS----PEDEEDPLNELRKT--VRLYQAGN 503
            ..|:  |.:.|.:|||     .:.:::|...|.|.||    .:.|||.....|:|  ....::|.
Zfish   533 GVES--EPLFPIIKEEPEKEQPISSREAGSGEEEAGSSSQQADREEDEDRRSRRTGGEEAERSGR 595

  Fly   504 YSPRYIREEDFTGRRAQNEDVDEPEA----EGLLYE----------------------------E 536
            .||    ||:..|...:.|..:.|||    |.|:.:                            |
Zfish   596 SSP----EEEKKGEEEEGEKDEAPEAVLTEEDLIQQSQAEYDSGRYSPTLLQNSELPLDTHIIAE 656

  Fly   537 EDDERRTQRQRLLILHPERVDNNQLT------PQELRMRNEAKQGMQGDEAEFSVETTLDAVPQL 595
            |:|     .||||:...:.    |:|      .::|.:| .||:||.||||:||||..|.....|
Zfish   657 EED-----LQRLLLARRQM----QVTGDASESAEDLFVR-RAKEGMGGDEAQFSVEMPLTGKMYL 711

  Fly   596 ATDKYRPRKPRYFNRVHTGFEWNKYNQTHYDMDNPPPKIVQGYKFNIFYPDLMDKSQTPQYFLTP 660
            ..|||||||||:|||||||||||||||||||.||||||||||||||||||||:||..||||||.|
Zfish   712 WADKYRPRKPRFFNRVHTGFEWNKYNQTHYDFDNPPPKIVQGYKFNIFYPDLIDKRSTPQYFLEP 776

  Fly   661 CADNGDFAVLRFHTGPPYEDIAFKIVNREWEFSYKRGFRCQFHNNIFQLWFHFKRYRYRR 720
            |.||.||.:||||.|||||||||||||||||:|::.||||||.|.|||||||||||||||
Zfish   777 CPDNKDFGILRFHAGPPYEDIAFKIVNREWEYSHRHGFRCQFANGIFQLWFHFKRYRYRR 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cactin	NP_523422.4	Endonuc_Holl	202..>274	CDD:295105	39/71 (55%)
		Cactin_mid	243..432	CDD:287304	103/188 (55%)
		CactinC_cactus	598..720	CDD:286775	104/121 (86%)
cactin	XP_005168488.1	Cactin_mid	330..515	CDD:287304	97/184 (53%)
cactin	XP_005168488.1	CactinC_cactus	712..836	CDD:286775	93/109 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596927
Domainoid	1	1.000	248	1.000	Domainoid score	I2112
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69553
Inparanoid	1	1.050	671	1.000	Inparanoid score	I715
OMA	1	1.010	-	-		QHG54753
OrthoDB	1	1.010	-	-		D1252926at2759
OrthoFinder	1	1.000	-	-		FOG0005003
OrthoInspector	1	1.000	-	-		oto39215
orthoMCL	1	0.900	-	-		OOG6_102945
Panther	1	1.100	-	-	LDO	PTHR21737
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1715
SonicParanoid	1	1.000	-	-		X4073
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940