DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and Wwtr1

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001161753.1 Gene:Wwtr1 / 97064 MGIID:1917649 Length:452 Species:Mus musculus


Alignment Length:549 Identity:114/549 - (20%)
Similarity:163/549 - (29%) Gaps:166/549 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  1212 ALLNELLVGLLLLKRDRPQCLGGLRWARLFLPLLRVLDRLNRALGEGELRDGDDMGWPGIICRGG 1276
            :||..|.:|       :....||....||...||...:|....              |||.....
Mouse    18 SLLQTLFMG-------QSGSRGGCARLRLLCRLLAQWERPRPV--------------PGIKMNPS 61

  Fly  1277 --PKGGPPPADPETHYVRRADMENLLLDGSRCIILAGYVCDLSGYNCESETLRSVLDSGLGKDLT 1339
              |...|||.....|..:..|.:                                |::.....:.
Mouse    62 SVPHPLPPPGQQVIHVTQDLDTD--------------------------------LEALFNSVMN 94

  Fly  1340 AEMSSQVHRTAMEHILEHHKLGKYMVQASTEEKSSAPGPSRLT----HFSSECALAQL-LGLVAN 1399
            .:.||...:...|...:....|.:..|:||:.....||| ||.    |..|..:.|.| ||..|.
Mouse    95 PKPSSWRKKILPESFFKEPDSGSHSRQSSTDSSGGHPGP-RLAGGAQHVRSHSSPASLQLGTGAG 158

  Fly  1400 LMCSGPALQPAELQCRQLDKSSLLSGGLQLLQPSNPFDEEKGEARSSHSCHSTAGNTPTELPPPL 1464
             ...|||.|.|.|:.:..|.:..|        |..|..|....|.......:......|...|..
Mouse   159 -AAGGPAQQHAHLRQQSYDVTDEL--------PLPPGWEMTFTATGQRYFLNHIEKITTWQDPRK 214

  Fly  1465 PMQQ-----QLAPGRGKSQLQLRADAFISGLAEARVSEPPVAAWLALTERYCKAHNLMWHQEFAT 1524
            .|.|     .|.|....:.:..|:.|         ||:|.:|.            |....|..||
Mouse   215 VMNQPLNHVNLHPSITSTSVPQRSMA---------VSQPNLAM------------NHQHQQVVAT 258

  Fly  1525 -----EHPVQELERLLSAVLIRHQYLGGLVLNALETEVPPPRQLGEIIRLVH-QAKWSVVRTRQ- 1582
                 .||.|.....|.:           |.|||.|:    :|..:.:||.. |.:...:|.|| 
Mouse   259 SLSPQNHPTQNQPTGLMS-----------VPNALTTQ----QQQQQKLRLQRIQMERERIRMRQE 308

  Fly  1583 QLNRSYKEVCAPILERLRFLLYEVRPAISPQQRGLRRL---PILQRPPRFKMLVRRLLQELRSSR 1644
            :|.|....:|..:......:.....||:|...|.:...   |.|...|            ..|..
Mouse   309 ELMRQEAALCRQLPMETETMAPVNTPAMSTDMRSVTNSSSDPFLNGGP------------YHSRE 361

  Fly  1645 Q-------------PAKPEDLLNASIQQEQEKKPQSMPKQELEEQEEEETLLRRLNERQIHGEGE 1696
            |             |..|||.|:            :|.:.:..|...:..:  .:|.:|......
Mouse   362 QSTDSGLGLGCYSVPTTPEDFLS------------NMDEMDTGENSGQTPM--TVNPQQTRFPDF 412

  Fly  1697 LD--PALMQDIVDFALQDSC----DVETA 1719
            ||  |....|:.....:|..    |||:|
Mouse   413 LDCLPGTNVDLGTLESEDLIPLFNDVESA 441

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597 6/72 (8%)
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
Wwtr1NP_001161753.1 WW 182..213 CDD:197736 5/30 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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