DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and Hecw1

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_006516872.1 Gene:Hecw1 / 94253 MGIID:2444115 Length:1605 Species:Mus musculus


Alignment Length:1780 Identity:337/1780 - (18%)
Similarity:565/1780 - (31%) Gaps:633/1780 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  3321 FVNKKPALVIGLDAVFVNRVACGSSHSIAWGLPNASSDEEKRGPVPFSSTRDPLGGSSLGIYEAE 3385
            |.|..|.|.|.:..         ..|||...||:  ..:|:|..:        :|.:...|::||
Mouse   223 FFNPDPYLKISIQP---------GKHSIFPALPH--HGQERRSTI--------IGNTVNPIWQAE 268

  Fly  3386 -------TMQTLKQEAK-------PLNQSSLSESLALETPAAR---QAALGHVLRAMSILQARQL 3433
                   ....|:.|.|       |:.:..|.:   |..|..|   :.|:|.  |.:|....|:|
Mouse   269 HFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGK---LSMPVQRLLERHAIGD--RVVSYTLGRRL 328

  Fly  3434 IVAALTSHSKVNFKERGAVGGEEDHLIGGPIMGAPLQLAET--------IAQGGGEAPADAT--- 3487
            ....::...:..|:...::..:::.:   .:...|...|||        :....||...|||   
Mouse   329 PTDHVSGQLQFRFEITSSIHADDEEI---SLSAEPESSAETQDSIMNSMVGNSNGEPSGDATEFC 390

  Fly  3488 -DA---------GL-------QEHSPEAAVDALTGGMSG--GAN------------------TLP 3515
             ||         |:       |||:  ..|:...|.|..  |:|                  |.|
Mouse   391 KDAKPESPSEGNGVNSSENQNQEHA--GPVEEAAGAMEARDGSNVSEAPEEPGELQDPEQHDTQP 453

  Fly  3516 PLSAGPLSAFQSLTGSLSMSGSLSSSALPQHKHSRMSASAMSVMAATMTQQEEMLSHISHCHGLD 3580
            .|||      :.:...|.:.....||.||:...:..|......:.....::|||..........:
Mouse   454 TLSA------EEVAEGLPLDEDSPSSLLPEENTALGSKVEEETVPENGAREEEMQKGKDEEEEEE 512

  Fly  3581 DFGGL-LGEPEAKSLVELLKLAVCGRCGPPSTSQTIADTLISLGAG---TPAVAAMLLETCI--- 3638
            |...| .|||..:     |:::|..:..|.|...:..:|:|:...|   ||....:.:.|.:   
Mouse   513 DVSTLEQGEPGLE-----LRVSVRKKSRPCSLPVSELETVIASACGDAETPRTHYIRIHTLLHSM 572

  Fly  3639 --------TELEDLCTSRHCLGKLPKPVMQESSHPYVDNVNVTGVVRIPGAEMLRLEFDSQCSTE 3695
                    ||.||        |...:..::|||..  |.::               |.|:..:  
Mouse   573 PSAQRGSTTEEED--------GLEEESTLKESSEK--DGLS---------------EVDTIAA-- 610

  Fly  3696 KRNDPLVIMDG--TGRVLAMRSGREFAHWAPEIRVLGDELRWKFSSDSSVNGWGWRFWVHAIMPA 3758
               ||..:.||  .|..|.|         ||              ||.|    |..|  .::...
Mouse   611 ---DPQSMEDGESDGATLCM---------AP--------------SDCS----GGHF--SSLSKG 643

  Fly  3759 ATLGESGSDRAVLSQPSMALVMSLLDSRLAPRQPSVLLRLASALAACSQLGALTTAQRIWSLRKL 3823
            ...|:.|.     :.||..     .:|..:|:|                                
Mouse   644 IGAGQDGE-----AHPSTG-----SESDSSPQQ-------------------------------- 666

  Fly  3824 HAVLLLEQAPRPQDPSLSTLLQPLIPELLRQYEYEEPQVRGGIHLMHSDYFKTLAALACDMQ-LD 3887
                                                    |..|          :...||.. ..
Mouse   667 ----------------------------------------GADH----------SCEGCDASCCS 681

  Fly  3888 AALPATSSSSSSSAAPGAISST---GDVHKWAWFKRYCI--AVRVAQSLIRRTELPRAFCLEVRK 3947
            .:..:||..|||..:....||:   |: :::|...|:..  :.::::|.:..::...    |...
Mouse   682 PSCYSTSCYSSSCYSSSCYSSSCYNGN-NRFASHTRFSSVDSAKISESTVFSSQEDE----EEEN 741

  Fly  3948 KFAEMLPSS--------SSNSNANP---GCQSPGASMLNSTTSLSSSTVSNVSPPPGITGEQPDL 4001
            ...|.:|.|        .|.:.|.|   ...:||.:...||..|.       ||..|        
Mouse   742 SAFESVPDSVQSPELDPESTNGAGPWQDELAAPGGNAARSTEGLE-------SPMAG-------- 791

  Fly  4002 HCHAHQLESTSTLLHEDHTLFQAPHDAQLLQWLNRRPDDWALSWGGASTIYGWGHNHRGQLGGLE 4066
              .:::.|....:||....:.|.|         :.||:                |:|        
Mouse   792 --PSNRREGECPILHNSQPISQLP---------SLRPE----------------HHH-------- 821

  Fly  4067 GSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSL 4131
                 .||..|.|                                       ..:|.        
Mouse   822 -----YPTIDEPL---------------------------------------PPNWE-------- 834

  Fly  4132 QHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNR-MSYDRPKLVEHLNGMSVADIAC 4195
                             ..:.:.|.|:        .:.|.|| .::.||.:....:||    |..
Mouse   835 -----------------ARIDSHGRVF--------YVDHINRTTTWQRPSMAPTPDGM----IRS 870

  Fly  4196 GSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDD 4260
            ||.|..                         :||..:       |:.|.....:..|:    .|.
Mouse   871 GSVHQM-------------------------EQLNRR-------YQNIQRTMATERAE----EDS 899

  Fly  4261 DNVWSWGDGDYGKLGRGGSD---------------GCKLP---YKIESLAGLGVVKVECGSQFSV 4307
            .|..|....|.|..|.||||               |...|   .|:..|.....||.....:|..
Mouse   900 GNQNSEQIPDGGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKVTLLLQSPAVKFITNPEFFT 964

  Fly  4308 ALTKSGAVY------TWGK----------GDFHRLGHGS-------------------------- 4330
            .|..:.:.|      |..|          .:|.|..|..                          
Mouse   965 VLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDH 1029

  Fly  4331 ------VDHVRR------PKKVAALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTV 4383
                  |||..|      |:  ..||..::.:..|...|......    |:.|:..|.....| .
Mouse  1030 QGKSFFVDHNSRATTFIDPR--IPLQNGRLPNHLTHRQHLQRLRS----YSAGEASEVSRNRG-A 1087

  Fly  4384 TAIQRP--RLVAALQGKHIVKVTCGSAHTLALSTSQLSERLRPLPNPPLEYDLVRDLAP------ 4440
            :.:.||  .|:||::.:|       ...:|.|:   .::::......|..::::::..|      
Mouse  1088 SLLARPGHSLIAAIRSQH-------QHESLPLA---YNDKIVAFLRQPNIFEMLQERQPSLARNH 1142

  Fly  4441 ---EALH-ARLILLHHFSELVCPC-LAMLPISGDLSLGALKDVLVYNIKEAAFRKVI----QTTM 4496
               |.:| .|....|...:|.|.. |.:|     |||.. ::::.|...::||....    :.:.
Mouse  1143 TLREKIHYIRTEGNHGLDKLSCDADLVIL-----LSLFE-EEIMSYVPLQSAFHPGYSFSPRCSP 1201

  Fly  4497 VRDKQHGPVIELNRIQVK-----------RSRNRCNGLAGIDGMKSVFGQMVQKLPLLTQ----- 4545
            ....|:.|  .|.|...:           :.||....|..     ..|||...|:.|:.:     
Mouse  1202 CSSPQNSP--GLQRASARAPSPYRRDFEAKLRNFYRKLEA-----KGFGQGPGKIKLIIRRDHLL 1259

  Fly  4546 -----EALA-----LPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEA 4600
                 :.:|     |......:.||||...|..|...|....:..|        |.|...|..|.
Mouse  1260 EGTFNQVMAYSRKELQRNKLYITFVGEEGLDYSGPSREFFFLLSQE--------LFNPYYGLFEY 1316

  Fly  4601 GANRDCFLLDPTLSSVLQ--MNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTE 4663
            .||....:....:|:.::  :..|||.|.::|:|:.....|......|.::   |.:..|.||::
Mouse  1317 SANDTYTVQISPMSAFVENYLEWFRFSGRILGLALIHQYLLDAFFTRPFYK---GLLKLPCDLSD 1378

  Fly  4664 ---VDRDYVAGLLCIR--NMDDDPKL-FTALELPFSTSSARGHEVPLSTRYTHISPRNRAEYVRL 4722
               :|.::...|..::  |:.|...| ||..|..|...:.|  |:......|.::.:|:.||:..
Mouse  1379 LEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTER--ELKSGGANTQVTEKNKKEYIER 1441

  Fly  4723 ALGFRLHE-FDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYK-GFDP 4785
            .:.:|:.. ..:|.:|:..|..:|:...|:|:|.|.||:.::.|:.:|.|...::...|: |:..
Mouse  1442 MVKWRVERGVVQQTEALLRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHD 1506

  Fly  4786 SSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLP-RTIADFRGRDFVLQ-VLEKNPPDHFLPESY 4848
            ...::.|||..:|.|.|::|...|:||.|.:.:| ...|..||.:.:.: .:||......||.::
Mouse  1507 GHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAH 1571

  Fly  4849 TCFFLLKMPRYSCKAVLLEKLKYAI 4873
            |||..|.:|.|...::|.|||..|:
Mouse  1572 TCFNRLDLPPYPSYSMLYEKLLTAV 1596

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826 8/28 (29%)
RCC1_2 4136..4166 CDD:290274 2/29 (7%)
RCC1 4154..4203 CDD:278826 13/49 (27%)
RCC1 4206..4257 CDD:278826 5/50 (10%)
RCC1 4260..4309 CDD:278826 16/66 (24%)
RCC1 4312..4360 CDD:278826 15/101 (15%)
RCC1 4364..4413 CDD:278826 11/50 (22%)
HECTc 4509..4880 CDD:238033 99/403 (25%)
HECTc 4553..4878 CDD:214523 88/333 (26%)
Hecw1XP_006516872.1 HECW_N 66..185 CDD:374632
C2_NEDL1-like 206..342 CDD:176073 30/142 (21%)
Neuromodulin 378..500 CDD:369001 27/129 (21%)
WW 829..858 CDD:366073 7/100 (7%)
HECW1_helix 947..1013 CDD:375862 11/65 (17%)
WW 1019..1050 CDD:197736 5/32 (16%)
HECTc 1249..1603 CDD:238033 91/361 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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