DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and TRIP12

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_024308991.1 Gene:TRIP12 / 9320 HGNCID:12306 Length:2092 Species:Homo sapiens


Alignment Length:2375 Identity:464/2375 - (19%)
Similarity:726/2375 - (30%) Gaps:760/2375 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  2960 PGSTAGAGAVSTSHEEAAAAPEQDLPCTVMVWGLNDKEQLGGLK----------GSKVKVPTF-S 3013
            |.:..|.....:....|.|.|:.|        .:..:..||..|          .|..|.|.. |
Human     5 PNNNPGGSLRRSQRNTAGAQPQDD--------SIGGRSHLGQAKHKGYSPPESRKSNSKAPKVQS 61

  Fly  3014 QTISRLRPIHIAG---GSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKK 3075
            .|.|.|...|::.   .|.|..||.|.............:.|           |:|       ||
Human    62 NTTSELSRGHLSKRSCSSSSAVIVPQPEDPDRANTSERQKTG-----------QVP-------KK 108

  Fly  3076 VAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAI 3140
                                      |...|.....:.|..|......|||.:.:    .|:.:.
Human   109 --------------------------DNSRGVKRSASPDYNRTNSPSSAKKPKAL----QHTESP 143

  Fly  3141 SSQGELYTWGLGEYGRLGHGDNTTQLK----PKLVTALAGRRVVQVACGSRDAQTLALTEDGAVF 3201
            |...:.::     ..:..|.|...|||    |.  |:.|..|......||| :|....||...|.
Human   144 SETNKPHS-----KSKKRHLDQEQQLKSAQSPS--TSKAHTRKSGATGGSR-SQKRKRTESSCVK 200

  Fly  3202 SWGDGDFGKLGRGGSEGSDTPHEIERLS------GIGVVQIECGA----QFSLALTRAGEVWTWG 3256
            |..    |....|..|.|..|.::...|      |...:.....|    ..|.|:..|......|
Human   201 SGS----GSESTGAEERSAKPTKLASKSATSAKAGCSTITDSSSAASTSSSSSAVASASSTVPPG 261

  Fly  3257 KGDYYRLGHGGDQH-------VRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQVYAWG------ 3308
            .    |:..|.||:       ...|.|....|.:.           .:.|.....:.|.      
Human   262 A----RVKQGKDQNKARRSRSASSPSPRRSSREKE-----------QSKTGGSSKFDWAARFSPK 311

  Fly  3309 ----DNDHGQQGSGNTFVNKK-PALVIGLDA--VFVNRVACGSSHSIAWGLPN--ASSDEEKRGP 3364
                .......||..:..:|. |:   ||.|  ..:.:.....|.|....||:  .|:.::..|.
Human   312 VSLPKTKLSLPGSSKSETSKPGPS---GLQAKLASLRKSTKKRSESPPAELPSLRRSTRQKTTGS 373

  Fly  3365 VPFSSTRDPLGGSSLGIYEAETMQTLKQEAKPLNQSSLSESLALETPAARQAALGHVLRAMSILQ 3429
            ...:|.|    ||.||...|...:..::.|.|.:......|.|..|..|.|.|..    :.|:..
Human   374 CASTSRR----GSGLGKRGAAEARRQEKMADPESNQEAVNSSAARTDEAPQGAAA----SSSVAG 430

  Fly  3430 ARQLIVAALTS-HSKVNFKERGAV------GGEEDHLIG--GPIMGAPLQLAETIAQGGGEAPAD 3485
            |    |...|| .|:.:..|.|.:      .|...||.|  ||.|.   ||.......|..:.|.
Human   431 A----VGMTTSGESESDDSEMGRLQALLEARGLPPHLFGPLGPRMS---QLFHRTIGSGASSKAQ 488

  Fly  3486 ATDAGLQ----EHSPEAAVDALTGGMSGGANTL---PPLSAGPL---------------SAFQSL 3528
            ....|||    ....:|.::.....:.|...||   |..|..|.               .|.::|
Human   489 QLLQGLQASDESQQLQAVIEMCQLLVMGNEETLGGFPVKSVVPALITLLQMEHNFDIMNHACRAL 553

  Fly  3529 T---GSLSMSGSLSSSALPQHKHSRMSASAMSVMAATMTQQEEMLSHISHCHGLDDFGGLLGEPE 3590
            |   .:|..|.::...|:|...........:.|....:|.. ||||. .|...:...|||     
Human   554 TYMMEALPRSSAVVVDAIPVFLEKLQVIQCIDVAEQALTAL-EMLSR-RHSKAILQAGGL----- 611

  Fly  3591 AKSLVEL---------LKLAVCGRCG---PPSTSQTIADTLISLGAGTPAVAAMLLETCITELED 3643
            |..|:.|         ..||:...|.   .|.....:||:|       |.:...|.......:|.
Human   612 ADCLLYLEFFSINAQRNALAIAANCCQSITPDEFHFVADSL-------PLLTQRLTHQDKKSVES 669

  Fly  3644 LCTSRHCLGKL-------PKPVMQESSHPYVDNVNVTGVVRIPGAE-----MLRLEFDSQCSTEK 3696
            .|.   |..:|       ...:.|.:|...:.||....||..|...     |:...|...||   
Human   670 TCL---CFARLVDNFQHEENLLQQVASKDLLTNVQQLLVVTPPILSSGMFIMVVRMFSLMCS--- 728

  Fly  3697 RNDPLV---------------IMDGTGR-------VLAMRSGREFAHWA----------PEIRVL 3729
             |.|.:               ::.|...       .|..||.:|.....          |:..:.
Human   729 -NCPTLAVQLMKQNIAETLHFLLCGASNGSCQEQIDLVPRSPQELYELTSLICELMPCLPKEGIF 792

  Fly  3730 GDELRWKFSSDSSVNG--WGWRFWVHAIMPAATLGESGSDRAVLSQPSMALVMSLLDSRLAPRQP 3792
            ..:...|..:..:.:|  |.||                .||. |..|     .:.:|||:..   
Human   793 AVDTMLKKGNAQNTDGAIWQWR----------------DDRG-LWHP-----YNRIDSRIIE--- 832

  Fly  3793 SVLLRLASALAACSQLG----ALTTAQRIW-----SLRKLH----AVLLLEQAPRP-QDPSLSTL 3843
                      .|..|:|    :|:|..|::     |:::::    ....:::.|.| .:.:.|..
Human   833 ----------VAAHQVGEDEISLSTLGRVYTIDFNSMQQINEDTGTARAIQRKPNPLANSNTSGY 887

  Fly  3844 LQPLIPELLRQYEYEEPQVRGGIHLMHSDYFKTLAALACDMQLDAALPAT--------------- 3893
            .:....:...|...|:|:       :...:.|||..:..::...:|.||.               
Human   888 SESKKDDARAQLMKEDPE-------LAKSFIKTLFGVLYEVYSSSAGPAVRHKCLRAILRIIYFA 945

  Fly  3894 ---------SSSSSSSAAPGAISSTGDVHKWAWFKRYCIAVRVAQSLIRRTELPRAFCLEVRKK- 3948
                     .:.:.||.....:||..       .|....|:::|:.|:::  ||..|.:..|:: 
Human   946 DAELLKDVLKNHAVSSHIASMLSSQD-------LKIVVGALQMAEILMQK--LPDIFSVYFRREG 1001

  Fly  3949 ---FAEMLPSSSSNSNANPGCQSPGASMLNSTTSLSSSTVSNVSPPPGITGEQPDLHCHAHQLES 4010
               ..:.|..|.|...:.|...:.|:..:.||||:||.|.:..:......|.....|.....|:.
Human  1002 VMHQVKHLAESESLLTSPPKACTNGSGSMGSTTSVSSGTATAATHAAADLGSPSLQHSRDDSLDL 1066

  Fly  4011 T-----STLLH---------------------------EDHTLFQAPHDAQLLQWLNRRPDDWAL 4043
            :     |.:|.                           :..|..|:| .:..|..||.:      
Human  1067 SPQGRLSDVLKRKRLPKRGPRRPKYSPPRDDDKVDNQAKSPTTTQSP-KSSFLASLNPK------ 1124

  Fly  4044 SWGGASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPD-------- 4100
            :||..||        :.....:|                 |.:.|||.....|.:.|        
Human  1125 TWGRLST--------QSNSNNIE-----------------PARTAGGSGLARAASKDTISNNREK 1164

  Fly  4101 --------GKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVN---SGGKHCL----A 4150
                    ...|...|.|...:  .||:     ..|..||.:......:|   .||..||    :
Human  1165 IKGWIKEQAHKFVERYFSSENM--DGSN-----PALNVLQRLCAATEQLNLQVDGGAECLVEIRS 1222

  Fly  4151 LTTEGEV----------------YAWGEGEDGKLGHGNRMS------YDRP-------------- 4179
            :.:|.:|                |...:.|...:....|:.      :..|              
Human  1223 IVSESDVSSFEIQHSGFVKQLLLYLTSKSEKDAVSREIRLKRFLHVFFSSPLPGEEPIGRVEPVG 1287

  Fly  4180 -----KLVEHLNG---------MSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLR 4230
                 .||..:|.         :.|.|...|:.            |.|:|.              
Human  1288 NAPLLALVHKMNNCLSQMEQFPVKVHDFPSGNG------------TGGRGS-------------- 1326

  Fly  4231 PKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLA--- 4292
                :||..:....:.|     |.....|..||..|         :||      |.||:.||   
Human  1327 ----QALKFFNTHQLKC-----QLQRHPDCANVKQW---------KGG------PVKIDPLALVQ 1367

  Fly  4293 ---------GLG---------------------VVKVECGSQFSVALTKSGAVYTW--------- 4318
                     |.|                     :|:....:.::|.....|....|         
Human  1368 AIERYLVVRGYGRVREDDEDSDDDGSDEEIDESLVRYYIPTMYNVLYKVQGLWLKWLLLCFIQAA 1432

  Fly  4319 ---GKGDF-HRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQLG 4379
               ..|:. |||.....:|: .|..:...|..:..||        ...|..|......|..|:.|
Human  1433 QFLNSGNVRHRLQFYIGEHL-LPYNMTVYQAVRQFSI--------QAEDERESTDDESNPLGRAG 1488

  Fly  4380 --DGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQLSER---------LRPLPNPPLEYD 4433
              ..|.|...:|........|..|....|.|.|....||..:.:         :.|..:.|||..
Human  1489 IWTKTHTIWYKPVREDEESNKDCVGGKRGRAQTAPTKTSPRNAKKHDELWHDGVCPSVSNPLEVY 1553

  Fly  4434 LVRDLAPE-------ALHARLIL--LHHFSEL------VCPCLAMLP----ISGDLSLGA---LK 4476
            |: ...||       :|...|:|  ||..|..      ...|..::|    |:..|:..|   |:
Human  1554 LI-PTPPENITFEDPSLDVILLLRVLHAISRYWYYLYDNAMCKEIIPTSEFINSKLTAKANRQLQ 1617

  Fly  4477 DVLVY---NI------------------------------KEAAFRKVIQT------TMVRDKQH 4502
            |.||.   ||                              ::.|.::::.|      :..:|.:.
Human  1618 DPLVIMTGNIPTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNPEINQSDSQDSRV 1682

  Fly  4503 GPVIE-----LNRIQ-VKRSRNRCNGLAGIDGMKSV---------FGQMVQKLPLLTQEALALPH 4552
            .|.::     :||.: :|::.:....|.....|..:         .|..::...|::||......
Human  1683 APRLDRKKRTVNREELLKQAESVMQDLGSSRAMLEIQYENEVGTGLGPTLEFYALVSQELQRADL 1747

  Fly  4553 RVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRDCFLLDPTLSSVL 4617
            .:|:    ||.|.......|:...:....||.     |...|.||....|:            :.
Human  1748 GLWR----GEEVTLSNPKGSQEGTKYIQNLQG-----LFALPFGRTAKPAH------------IA 1791

  Fly  4618 QMNM-FRFLGVLMGIAVR----TGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCIRN 4677
            ::.| |||||.||..|:.    ...||.:...:.:.||.|.  |...||.::|......:..:.:
Human  1792 KVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETS--LTSHDLFDIDPVVARSVYHLED 1854

  Fly  4678 M--------DDDPKLFTALELPFSTSSARGHEV-PLSTRYT----------------HISPRNRA 4717
            :        .|..:...:|:....|.:..|..| .|...:|                .::..|..
Human  1855 IVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGKDIPVTIHNLE 1919

  Fly  4718 EYVRLALGFRLHE-FDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSP----DIPLGLLKSV 4777
            ||:||.:.:.|:| ...|..:.|||...|.|:..|..|...||..::|||.    |... |::..
Human  1920 EYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSKADTWDAKT-LMECC 1983

  Fly  4778 ATYKGFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEK----- 4837
            ....|:...|..|.:.:|::..|.|:::.|||:||.|..|||  :..||..:..|.::.|     
Human  1984 RPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLP--VGGFRSLNPPLTIVRKTFEST 2046

  Fly  4838 NPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYA 4872
            ..||.|||...||...||:|.||...::.|||..|
Human  2047 ENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIA 2081

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826 5/50 (10%)
RCC1 3091..3140 CDD:278826 8/48 (17%)
RCC1 3144..3194 CDD:278826 13/53 (25%)
RCC1 3197..3246 CDD:278826 11/58 (19%)
RCC1 3250..3298 CDD:278826 8/54 (15%)
RCC1 3302..3350 CDD:278826 10/60 (17%)
RCC1_2 4136..4166 CDD:290274 9/52 (17%)
RCC1 4154..4203 CDD:278826 12/98 (12%)
RCC1 4206..4257 CDD:278826 7/50 (14%)
RCC1 4260..4309 CDD:278826 14/81 (17%)
RCC1 4312..4360 CDD:278826 11/60 (18%)
RCC1 4364..4413 CDD:278826 12/50 (24%)
HECTc 4509..4880 CDD:238033 103/414 (25%)
HECTc 4553..4878 CDD:214523 94/360 (26%)
TRIP12XP_024308991.1 SR-25 99..>233 CDD:313680 38/193 (20%)
Arm_3 489..>714 CDD:330530 50/241 (21%)
WWE 808..874 CDD:308464 18/100 (18%)
HECTc 1690..2090 CDD:238033 103/418 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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