DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and MAGI1

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001028229.1 Gene:MAGI1 / 9223 HGNCID:946 Length:1462 Species:Homo sapiens


Alignment Length:1607 Identity:299/1607 - (18%)
Similarity:466/1607 - (28%) Gaps:630/1607 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly  2219 AELLAEQSHSTALDSEQVFVLGVLGAMG-------GHDLRPRVGLHCFHEGSHMVIASFTPKGRC 2276
            ::::.:::|.|:...|.....|..|.:|       .|...|.||          .:|:....|  
Human     2 SKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVG----------AVAAVEAAG-- 54

  Fly  2277 LLAPGG-----VGSGVGFVKVQLPAVMPHLDHTVFSLSRLPMNEMLLNAWTVLLYGPAPELRELP 2336
              .|||     :|.|...::||...|           |.||..::|         |.....:|..
Human    55 --LPGGGEGPRLGEGELLLEVQGVRV-----------SGLPRYDVL---------GVIDSCKEAV 97

  Fly  2337 S----SADGRL--DLALLRAQQLQ--------MAVLHTNGVLYRHQVALRRILKQRAP------- 2380
            :    ...|||  ||.....|:.|        ...:..|  ||||.|.    ...|:|       
Human    98 TFKAVRQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDN--LYRHAVP----CTTRSPREGEVPG 156

  Fly  2381 ---------------------------GSIYASPDEPDRSDAESQQPGEQDQQLSSGSGQEPQLL 2418
                                       |:.|.:|..|.:..:......:....|.|||.|     
Human   157 VDYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQ----- 216

  Fly  2419 IQCILLRATQASPVKACYSYMDLATAALNCIQSLATQAHQELSEGGGVPPNGRALSS-------- 2475
                       |..|...||.|:..|.:         .|.|..|...||....:.::        
Human   217 -----------STPKRTKSYNDMQNAGI---------VHAENEEEDDVPEMNSSFTADSGEQEEH 261

  Fly  2476 -------PPQPTMVHGVPVYNVAR----------------------------------------- 2492
                   ||..:.:...|:.:.::                                         
Human   262 TLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTT 326

  Fly  2493 ---------KEQKPSEQVEQKSKWPAAATDAQL-------------IGQIMEMGFTRRT------ 2529
                     |:|||.|:.|..........|::|             .|........|:|      
Human   327 SWLDPRCLNKQQKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPV 391

  Fly  2530 VELALK----------QLSLQAEIMPTPEQIVQWILEH----PDVCANTIEEDTLPLASSASSHD 2580
            :|...|          |...|.:.....:|..:|..:|    |.|..|               |.
Human   392 LEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPPVIPN---------------HP 441

  Fly  2581 P-EADSDNECPSSNSTTSSSTSSDTVEGQPMAVSGPAP-PVKFESRKDFQTADLYALYVRGLVRP 2643
            | ..:...|.|              ::|:|.....|:. ..||...|..:::..:...|.|...|
Human   442 PSNPEPAREVP--------------LQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEP 492

  Fly  2644 GMTVRCCRDFEEIKQGDMGTVLIVD----TEG---LHDLNVQVDWRNHGSTYWVCFVHIELVEAA 2701
            .       :|.:||.      |::|    .:|   ..|:.|.|:     .|..:...|.::|:..
Human   493 D-------EFLQIKS------LVLDGPAALDGKMETGDVIVSVN-----DTCVLGHTHAQVVKIF 539

  Fly  2702 QTHHQPRPPPIAVGARVRLRTSSLRYGMLC---PLRLGRSQGSSAIGVVSSVRSK-------QLT 2756
            |:        |.:||.|.|.        ||   ||.......::::....::..|       |.|
Human   540 QS--------IPIGASVDLE--------LCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQET 588

  Fly  2757 VDFP-DQPAWQGHINEVELVASQPTSATLPSLGDSCSQMPPSDLIEDWSRCIRSLTVSSNEAAAK 2820
            .|.| ...:..|.:|.::  .::|:|..  .:..:.|...|:|.:.     :.|...:..|....
Human   589 YDSPASHSSKTGKVNGMK--DARPSSPA--DVASNSSHGYPNDTVS-----LASSIATQPELITV 644

  Fly  2821 HLLNG--------SNQPW-------QSCSSGPCRHWIRLELHDRIL------VHSLTLKVSPEDH 2864
            |::.|        ::.|.       |...|..||   .|:..|.|:      |.:||       |
Human   645 HIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCR---GLKEGDLIVEVNKKNVQALT-------H 699

  Fly  2865 SHMPSLLEIRVGDCVDSLKEYTWIPVPAGASRVLLMQQ----VPTYYPWVEVVVKQCQNNGIQCK 2925
            :.:           ||.|.|     .|.|:...||:|:    ||...|..:.:.::...|..|..
Human   700 NQV-----------VDMLVE-----CPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHS 748

  Fly  2926 IHGIKFVGRRQQPDLQHILANAQFLASEYSAGVGPGSTAGAG----------AVSTSHEEAAAA- 2979
            :...:.:..........:|  .:|..:|..|   |..|..:|          |.|.|..|.... 
Human   749 VSSHRSLHTASPSHSTQVL--PEFPPAEAQA---PDQTDSSGQKKPDPFKIWAQSRSMYENRLPD 808

  Fly  2980 -PEQDLPCTVMVWGLNDKEQLGG---LKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKV 3040
             .|||    :.:|   .||...|   |.|::...|.:   |..:.|:..|.....|    :.|..
Human   809 YQEQD----IFLW---RKETGFGFRILGGNEPGEPIY---IGHIVPLGAADTDGRL----RSGDE 859

  Fly  3041 YACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKL 3105
            ..|.:||                  ||:            |..|.|.:.|        ..:..|.
Human   860 LICVDGT------------------PVI------------GKSHQLVVQL--------MQQAAKQ 886

  Fly  3106 GHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKL 3170
            ||.|.|.  :.::|.|:...:....:..|||                      |..|    :|..
Human   887 GHVNLTV--RRKVVFAVPKTENEVPSPASSH----------------------HSSN----QPAS 923

  Fly  3171 VTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDT------PHEIE--- 3226
            :|  ..:|..|   ||:::..        ..|.|.|....:|.||..||..      |:::|   
Human   924 LT--EEKRTPQ---GSQNSLN--------TVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRR 975

  Fly  3227 -RLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIG----GLRGRRVI 3286
             ...|.|.|.:.     |::...||..:             |:..|..|..||    |....|..
Human   976 GENEGFGFVIVS-----SVSRPEAGTTF-------------GNACVAMPHKIGRIIEGSPADRCG 1022

  Fly  3287 HVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVN----RVACGSSHS 3347
            .:.||. ..|||                  :|.:..||..:.::.|.....|    |:..|...|
Human  1023 KLKVGD-RILAV------------------NGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESS 1068

  Fly  3348 IAWGLPNASSDEEKRGPVPFSSTRDPLGGSSLGIYEAETMQTLKQEA------------------ 3394
            .|..|.||    ||...:  ::|..|   |..|..|.......|||:                  
Human  1069 NATLLTNA----EKIATI--TTTHTP---SQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTV 1124

  Fly  3395 ----------------KPLNQSSLSESLALETPAARQAALGHVLRAMSILQARQLIVAALTSHSK 3443
                            :..|.......||.:.||.|   .|.:.....||:        :...:.
Human  1125 ELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAER---CGKMRIGDEILE--------INGETT 1178

  Fly  3444 VNFKERGAV-----GGEEDHLIGGPIMGAPLQLAETIAQGGGEAPADATDAGLQEHSPEAAVDAL 3503
            .|.|...|:     ||....|.              :.:|.|..|  ..|.....|.|       
Human  1179 KNMKHSRAIELIKNGGRRVRLF--------------LKRGDGSVP--EYDPSSDRHGP------- 1220

  Fly  3504 TGGMSGGANTLPPLSAGPLSAFQSLTGSLSMSGSLSSSALPQ-HKHS 3549
                :.|...:|.:.|||         ......||.||..|. ||.|
Human  1221 ----ATGPQGVPEVRAGP---------DRRQHPSLESSYPPDLHKSS 1254

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585 11/76 (14%)
Cul7 2624..2699 CDD:288381 15/81 (19%)
APC10-HERC2 2762..2932 CDD:176485 37/194 (19%)
RCC1 3037..3088 CDD:278826 9/50 (18%)
RCC1 3091..3140 CDD:278826 10/48 (21%)
RCC1 3144..3194 CDD:278826 8/49 (16%)
RCC1 3197..3246 CDD:278826 14/58 (24%)
RCC1 3250..3298 CDD:278826 11/51 (22%)
RCC1 3302..3350 CDD:278826 8/51 (16%)
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
MAGI1NP_001028229.1 PDZ_signaling 15..100 CDD:238492 24/118 (20%)
GuKc 122..293 CDD:214504 31/201 (15%)
WW 303..332 CDD:238122 0/28 (0%)
WW 361..390 CDD:278809 3/28 (11%)
PDZ 469..555 CDD:214570 26/119 (22%)
PDZ 640..723 CDD:214570 24/108 (22%)
MAGI_u5 722..805 CDD:293271 16/87 (18%)
PDZ_signaling 819..894 CDD:238492 25/121 (21%)
PDZ_signaling 968..1062 CDD:238492 26/130 (20%)
PDZ 1123..1205 CDD:214570 15/106 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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