DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and RCCD1

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001017919.1 Gene:RCCD1 / 91433 HGNCID:30457 Length:376 Species:Homo sapiens


Alignment Length:388 Identity:102/388 - (26%)
Similarity:161/388 - (41%) Gaps:94/388 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  4037 RPDDWALSWGGASTIYGWGHNHRGQ-LGGLEGSRIKTPTPCEA-LSLLRPVQLAGGEQSLFAVTP 4099
            ||..|          :|:|....|| ||...|.::.:|:|..| :.:.|  ..|....:.| ||.
Human     5 RPGAW----------FGFGFCGFGQELGSGRGRQVHSPSPLRAGVDICR--VSASWSYTAF-VTR 56

  Fly  4100 DGKLFATGYGSG--GRLGVGGSDSWAIPTLLG---------SLQHVFVKKVAVNSGGKHCLALT- 4152
            .|:|..:|..||  ||.    .|:||...||.         :|..|:..:.|:.  |:...|.. 
Human    57 GGRLELSGSASGAAGRC----KDAWASEGLLAVLRAGPGPEALLQVWAAESALR--GEPLWAQNV 115

  Fly  4153 ---TEGEVYAWGEGEDGKLG--------HGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITAS 4206
               .|||....||.:.|:|.        ...|..:.||...|    :....:..|:.|:..:.|:
Human   116 VPEAEGEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPE----LRARQLELGAEHALLLDAA 176

  Fly  4207 GHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWG---- 4267
            |.|.:||.||:|:||||..|.:|.|:|:|||.|....::|.|..  .::|:::..:::.||    
Human   177 GQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGW--HSVCVSETGDIYIWGWNES 239

  Fly  4268 --------------------------DGDYGKLGRGGSDGCKLPY--------KIESLAGLGVVK 4298
                                      ||...|...|..||...|:        .::...|...||
Human   240 GQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVK 304

  Fly  4299 VECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVAC 4361
            ..|||:.:..:|::|.:||||.|.:.:|||.....:.||::|.....|::      .:..|.|
Human   305 ASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQL------QVKAVTC 361

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274 8/33 (24%)
RCC1 4154..4203 CDD:278826 13/56 (23%)
RCC1 4206..4257 CDD:278826 21/50 (42%)
RCC1 4260..4309 CDD:278826 15/86 (17%)
RCC1 4312..4360 CDD:278826 13/47 (28%)
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
RCCD1NP_001017919.1 Interaction with KDM8. /evidence=ECO:0000269|PubMed:24981860 1..169 47/186 (25%)
ATS1 <156..340 CDD:227511 51/189 (27%)
RCC1 2 176..227 22/52 (42%)
RCC1 3 229..317 15/87 (17%)
RCC1 4 318..371 15/50 (30%)
RCC1 319..366 CDD:395335 15/49 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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