DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and UBE3B

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_569733.2 Gene:UBE3B / 89910 HGNCID:13478 Length:1068 Species:Homo sapiens


Alignment Length:498 Identity:131/498 - (26%)
Similarity:211/498 - (42%) Gaps:103/498 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly  4429 PLEYDLVRDLAPEALHARLILLHHFSELVCPCLAMLPISGDLSLGALKDVLVYNIKEAAFRKVIQ 4493
            |.::.|.:||.|..|...|......::|:   |..:|           .|:.:..:...||    
Human   612 PEDHWLRKDLKPSVLFQELDRDRKRAQLI---LQYIP-----------HVIPHKNRVLLFR---- 658

  Fly  4494 TTMVRDKQHGPVIE-------LNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPLLTQEALALP 4551
            |.:.::|:...::|       :..|.::|||...:|              .::|..|:|.|:   
Human   659 TMVTKEKEKLGLVETSSASPHVTHITIRRSRMLEDG--------------YEQLRQLSQHAM--- 706

  Fly  4552 HRVWKVKFVGE-SVDDCG----GGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRDCFLLDP 4611
            ..|.:||||.: .||:.|    |.:.|.:.|:...:.:.::.|...|      :|..|    |.|
Human   707 KGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTT------SGDER----LYP 761

  Fly  4612 TLSSVLQMN---MFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGE-----VLRPTDLTEVDRDY 4668
            :.:|.:..|   :|.|:|.::|.||..|..:.:..|.....||.|.     .....:|..:|.::
Human   762 SPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEF 826

  Fly  4669 VAGLLCIRNMDDDPKLFTALELPFS-TSSARG----HEVPLSTRYTHISPRNRAEYVRLALGFRL 4728
            ...|..|:..|.|   .|.|.|..| .....|    ||:....:...::..|:..|:.|...||:
Human   827 YKNLTSIKRYDGD---ITDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRM 888

  Fly  4729 H-EFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCG-SPDIPL-GLLKSVATYKGFDPSSALV 4790
            | :...|..|:..|...:|....:.:||..|||.::.| :.:|.| .|.|....|.||..|..::
Human   889 HTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVI 953

  Fly  4791 TWFWEVM-EEFTNQERSLFLRFVWGRTRLP---------------------RTIADFRG---RDF 4830
            .|.|::: .:||..||::||:||...:|.|                     :...|..|   |.|
Human   954 IWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGF 1018

  Fly  4831 VLQVLEKNPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAI 4873
            .  .:.|..|...||.|.|||.|||:|.||.|:||.|||:|||
Human  1019 F--TIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAI 1059

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033 115/411 (28%)
HECTc 4553..4878 CDD:214523 106/367 (29%)
UBE3BNP_569733.2 HECTc 682..1066 CDD:238033 115/410 (28%)
HECTc 707..1065 CDD:214523 106/368 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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