|
Fly 69 PDLYLRPLPFLDAKWLRADLIASLRNAADGAVLWNHLIQDCELVSSPTAPLLNARGQL------S 127
|.:.|:.|..|::.|:..| ..|:......|||::.|:.:.|:|..|...|.....|| |
Human 6 PPVKLKWLEHLNSSWITED-SESIATREGVAVLYSKLVSNKEVVPLPQQVLCLKGPQLPDFERES 69
Fly 128 YLGDDGKHYCGAQQLKCSCCQPEYCGPLSACNCDGCRPLDSDTAIKKLTTQAAAQQAAHLSQATD 192
...|:..||..|. |.|..|:.|:.
Human 70 LSSDEQDHYLDAL-------------------------LSSQLALAKMV---------------- 93
Fly 193 MVLSGWLWSQPPSQQARLDCQRSMISELQELALRAAGNCLSAQHLRQQLFIYERYFVAL------ 251
|..|.. |..||::|.:.:|.|.||
Human 94 -------------------CSDSPF----------------AGALRKRLLVLQRVFYALSNKYHD 123
Fly 252 KRERERERKSTTSAQAVASVTTANTTIAATTANAAVESQPAEQQAEHGALGLARVATHAALNFSF 316
|.:.::::.|..|:...|.|.:.:....::| :|.:| :.....|:..|
Human 124 KGKVKQQQHSPESSSGSADVHSVSERPRSST-DALIE-----------------MGVRTGLSLLF 170
Fly 317 AFLRRAWR---SGEDTEMCSELLSEALASLQELPEATLFEAAVVSSLWLEVMERSIKFLRLVAL- 377
|.||::|. ||....:|::::..|:..:..||..:|...:.:..:.|:.:.:...||:.|.:
Human 171 ALLRQSWMMPVSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKIPPMGLDCLSQVTTFLKGVTIP 235
Fly 378 ---GDPMGNRCTAPLNDRHTALCLLLELGVQKGTLAATLECVVLLL------LLWEKDRAGNDNR 433
.|.:|.|..:. |||.|..|:|:|...||.:.:.| ...||.:..:...
Human 236 NSGADTLGRRLASE---------LLLGLAAQRGSLRYLLEWIEMALGASAVVHTMEKGKLLSSQE 291
Fly 434 -------------DMPRKTGAPLQRILLRYQKIGATAKGGGIAGGEPAPVASATETFLRFLSLPK 485
.|.|..|:...|...| ||. :
Human 292 GMISFDCFMTILMQMRRSLGSSADRSQWR----------------EPT----------------R 324
Fly 486 SSAAIVDLRRAAVVIISHLDRMVQPLMPRCL----LRGGQATAASSSSAPQQRIYALGWPSLSKD 546
:|..:..|..||:.:...:.||.......|. ::.|.|...|.:. .:|. |.|.|..
Human 325 TSDGLCSLYEAALCLFEEVCRMASDYSRTCASPDSIQTGDAPIVSETC----EVYV--WGSNSSH 383
Fly 547 Q-----QGFSAEPTLSWSGESAGVPTLS----CRFQIK---QVACCETQMLILSQEGKLYTWRLA 599
| |....:|.|:.|...| .|:. |.|.|. .|..| ||....||.
Human 384 QLVEGTQEKILQPKLAPSFSDA--QTIEAGQYCTFVISTDGSVRAC----------GKGSYGRLG 436
Fly 600 KPEA------EPLPMEEVAHDVFISIAGHCEGRHFLAIDSNHNAYSWGTGEDHRLGHGDTHARAV 658
..:: :.|..|.......:|.:...:| |.||..:....:|||.|:..:||||::..:..
Human 437 LGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDG-HTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKY 500
Fly 659 PTKI-AALEQHCVQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMV 722
|..| ..|:...|..|..|..:|||:|..|.|.|||.|.:.|||||:|:.|::||||..:|: |
Human 501 PKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN--V 563
Fly 723 VDVALGSGDAHSLALTSEG-LVFAWGDGDYGKLGNGNCNGSLQPILVESLPR--VQRVFAGSQFS 784
.:|:.|| :|::||:.:| .|:::|.||.||||:|:.|...:|.::|:|.. :::|.||||.|
Human 564 GEVSCGS--SHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSS 626
Fly 785 VALSSEGQLYTWGKATCLGHQLVERSVQGCSVPRLVSSLQHKRIVDVAVSVAHCLALSSSGEVFG 849
:||:|.||:|.||...|||....|.:... |:|:..|...|||||::..:||||||...||:.
Human 627 LALTSTGQVYAWGCGACLGCGSSEATALR---PKLIEELAATRIVDVSIGDSHCLALSHDNEVYA 688
Fly 850 WGRNDSQQICPASVSSEPLLRTPILVSLPTFPASGIACTSAQSLVWT--QSSHQGVPRRAPFVVD 912
||.|...| |....|:.|:.:...:..|.......|:..::.||.|| ....|.|....|:.||
Human 689 WGNNSMGQ-CGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWTALPRDRQVVAWHRPYCVD 752
Fly 913 LGEPTFRLLDQLLGMCSSQDNRQTP------NQESECIAVACLNLFRLQLLALIANGVEPRQVGL 971
|.|.||..|...|.....:.|.:.| ::|.......||.|....|...:|.||....:|.
Human 753 LEESTFSHLRSFLERYCDKINSEIPPLPFPSSREHHSFLKLCLKLLSNHLALALAGGVATSILGR 817
Fly 972 ASGSRLLCSLKTRILGLAGGSQVLRTIQVAAQQALQDGWSVLLPTAAERAQTLTSLLPSEPG--Q 1034
.:|. |.:|..|:: .|.|...||....:.|..|.::|||...||.:.|.||||..|. :
Human 818 QAGP--LRNLLFRLM----DSTVPDEIQEVVIETLSVGATMLLPPLRERMELLHSLLPQGPDRWE 876
Fly 1035 ASSAGHRFMTDLLVSSLMAEGGLESALQHAIRLE----SSSCSA------------DCGDGVHLP 1083
:.|.|.|...|::::||.....:.|.|.::...: ||.|:. .|....|
Human 877 SLSKGQRMQLDIILTSLQDHTHVASLLGYSSPSDAADLSSVCTGYGNLSDQPYGTQSCHPDTH-- 939
Fly 1084 LLQLITRLLSNNAALSQTRLSPTLGKQQEK------EEEEREQQHQEPSTSPSLSLLHRFQRLLL 1142
|.:::.:.|..|......:....|.|..:| ..|..:..|.. .||...|:.||
Human 940 LAEILMKTLLRNLGFYTDQAFGELEKNSDKFLLGTSSSENSQPAHLH-------ELLCSLQKQLL 997
Fly 1143 S--HIHQAQPEEETTGAEALLLQYMHALIPACVATLQKAHELALQCREPGENSFGQMVGHLGRVL 1205
: ||:.. .|.:.:.|||.:::..|:|.......::..|..: .|...|.|: .|..|:
Human 998 AFCHINNI---SENSSSVALLHKHLQLLLPHATDIYSRSANLLKE--SPWNGSVGE---KLRDVI 1054
Fly 1206 QADISDALLNELLVGLLLLKRD--RPQCLGGLRWARLFLPLLRVLDRLNRALGEGELRDGDDMGW 1268
....:.::|.:::..||||... || .....|.||..||.|||.|...:|.:..::.|
Human 1055 YVSAAGSMLCQIVNSLLLLPVSVARP-------LLSYLLDLLPPLDCLNRLLPAADLLEDQELQW 1112
Fly 1269 PGIICRGGPK----GGPPPADPETHYVRRADMEN--LLLDGSRCIILAGYVCDLSGYNCESETLR 1327
| ..|||: .|.|...|...:|...|:|. .||.| || |.|
Human 1113 P---LHGGPELIDPAGLPLPQPAQSWVWLVDLERTIALLIG-RC---------LGG--------- 1155
Fly 1328 SVLDSGLGKDLTAEMSSQVHRTAMEHILEHHKLGKYMVQ---ASTEEKSSAPGPSRLTHFSSECA 1389
|:| .|.||:.:|
Human 1156 ------------------------------------MLQGSPVSPEEQDTA-------------- 1170
Fly 1390 LAQLLGLVANLMCSGPALQPAELQCRQLDK--SSLLSGGLQLLQPSNPFDEEKGEARSSHSCHST 1452
..:...|...| .|:...|||| |.||...|...:...|||
Human 1171 ----YWMKTPLFSDG-----VEMDTPQLDKCMSCLLEVALSGNEEQKPFD--------------- 1211
Fly 1453 AGNTPTELPPPLPMQQQLAPGRGKSQLQLRADAFISGLAEARVSEPPVAAWLALTERYCKAHNLM 1517
.:|.|.:.:...||.|..| ||..:.|:::.: |..:.:
Human 1212 -----YKLRPEIAVYVDLALGCSK--------------------EPARSLWISMQD-YAVSKD-- 1248
Fly 1518 WHQ-EFATEHPVQELERLLSAVLIRHQYLGGLVLNALETEVPPPRQLGEIIRLVHQAKWSVVRTR 1581
|.. ..:.|..:..:.|.:.|.|::|..| |.....|:...|.:.|.|:.|.|:: ||:|
Human 1249 WDSATLSNESLLDTVSRFVLAALLKHTNL--LSQACGESRYQPGKHLSEVYRCVYK-----VRSR 1306
Fly 1582 QQLNRSYKEVCAPILERLRFLLYEVRPA-ISPQQRGLRRLPILQRPPRFKMLVRRLLQELRSSRQ 1645
....::.:.:......|.|::......| :.||:... .|:..:
Human 1307 LLACKNLELIQTRSSSRDRWISENQDSADVDPQEHSF----------------------TRTIDE 1349
Fly 1646 PAKPEDLLNASIQQEQEKKPQSMPKQELEEQEEEETLLR-------------------------- 1684
.|:.| :|.:..:.:..|:.|.||:|.|..::.
Human 1350 EAEME-------EQAERDREEGHPEPEDEEEEREHEVMTAGNLVFVLHVTEIFQCFLSAREVARS 1407
Fly 1685 ----RLNERQIHGEGELDP---ALMQDIVDFALQDSCDVETARRAMYCQMQRYQLRLAGLQIVQQ 1742
|:|.....|....|| :..:..|...|.:..||.|| |....:.|..|.:.|:..|
Human 1408 RDRDRMNSGAGSGARADDPPPQSQQERRVSTDLPEGQDVYTA--ACNSVIHRCALLILGVSPV-- 1468
Fly 1743 LLELHGLLDAAQYSLLNGFLGLHLKSTSSGGGSTGSGSSLHVLGQLNMISAYQKARLLLAQSRVL 1807
:|..|.....|.|.....|.|.|||......|| ..:..::......||:.::|. .
Human 1469 -------IDELQKRREEGQLQQPSTSASEGGGLMTRSESL--TAESRLVHTSPNYRLIKSRSE-S 1523
Fly 1808 DWAVRELRRLVNQEQQGHA-RGKDSTNLGTYVLLKRLPRARFLLSVFGLLAKELGPNELGFLINS 1871
|.:..| .:::|:| .|:.:.:|. |....|.|..|.:|| :|.|.:
Human 1524 DLSQPE------SDEEGYALSGRRNVDLD----LAASHRKRVYLLLFG----QLSPRK------- 1567
Fly 1872 GLLGTVLGLLAQTGGEGATGGQVHGELSILYEDSVLKQKSSKAQL--------SGPDLAKLMKIG 1928
:...:....|.:|.:|..| .||..:.|.|:..| |..||.|.:.:.
Human 1568 -----------KKSFKQVHDGPMHSQLESL-SDSWARLKHSRDWLCNSSYSFESDFDLTKSLGVH 1620
Fly 1929 TRIVRGADWKWGDQDGNPPG------------EGRIISEVGEDGWVRVEWYTGATNSYRM---GK 1978
|.|.....:..||. ||.|| :..||:. |...:|.|....|.:...: |.
Human 1621 TLIENVVSFVSGDV-GNAPGFKEPEESMSTSPQASIIAM--EQQQLRAELRLEALHQILVLLSGM 1682
Fly 1979 EGQYDLQLADSALNVASPTEPEREDVSGSEASPTSDSHPSKLLRHC------------------- 2024
|.:..:.||.|.|: ||.::|....|...:.|..|
Human 1683 EEKGSISLAGSRLS------------SGFQSSTLLTSVRLQFLAGCFGLGTVGHTGGKGESGRLH 1735
Fly 2025 -------AAKLLQILAVGTGLH------GAQLDKDALRG------------MTSMFRTIIYPKPS 2064
|||....:.:...:| .|.|:: ||:. :.::|...::.:|.
Human 1736 HYQDGIRAAKRNIQIEIQVAVHKIYQQLSATLER-ALQANKHHIEAQQRLLLVTVFALSVHYQPV 1799
Fly 2065 MSNISYALGWLNLGFIRAISGDCPRLCLELSTPGWLSHYLSLLEQPAGNEAGVYRQLHCLRLLQL 2129
..:::.:.|.||: ..:|| .|...|...|.||.:...::.....::...||||:
Human 1800 DVSLAISTGLLNV---------LSQLC---GTDTMLGQPLQLLPKTGVSQLSTALKVASTRLLQI 1852
Fly 2130 ILAQWGAEEEPRMPALVHQLFATLGRIALHCPGDASLLPTAEGKARVLLTAS------HSGSVAE 2188
:....|...:...|.:|..|...| .|.|.....:..||..|| ..|...|
Human 1853 LAITTGTYADKLSPKVVQSLLDLL----------CSQLKNLLSQTGVLHMASFGEGEQEDGEEEE 1907
Fly 2189 ELV------------ALLRRLHTL--------------------------PSWNPVINSFLAQKL 2215
:.| |.||:.|.. |.|..|:.:..:||.
Human 1908 KKVDSSGETEKKDFRAALRKQHAAELHLGDFLVFLRRVVSSKAIQSKMASPKWTEVLLNIASQKC 1972
Fly 2216 -------------------------------------------------CVAAELLAEQSHSTAL 2231
|:....:|:..|:..:
Human 1973 SSGIPLVGNLRTRLLALHVLEAVLPACESGVEDDQMAQIVERLFSLLSDCMWETPIAQAKHAIQI 2037
Fly 2232 -DSEQVFVLGVLGAMGGHDLRPRVGLHCFHEGSHMVIASFTP-KGRC-------LLAPGGVGSGV 2287
:.||...|...|.:...| |...:...||.| |.:| :|..|..|.|.
Human 2038 KEKEQEIKLQKQGELEEED-----------ENLPIQEVSFDPEKAQCCLVENGQILTHGSGGKGY 2091
Fly 2288 GFV-----------KVQLPAVMPHLDHTVFSLSRLPMNEM---------LLNAWTVLLYGPAPEL 2332
|.. |..:.......:.|...:||.|:::. |..|::..||....:.
Human 2092 GLASTGVTSGCYQWKFYIVKENRGNEGTCVGVSRWPVHDFNHRTTSDMWLYRAYSGNLYHNGEQT 2156
Fly 2333 RELPSSADGRLDLALLRAQQLQMAVLHTNGVLYRHQVALRRILKQRAPGSIYASPDEP-----DR 2392
..|.|...|.....:| .:..|.| |...:.:|| |.
Human 2157 LTLSSFTQGDFITCVL-------------------DMEARTI-------SFGKNGEEPKLAFEDV 2195
Fly 2393 SDAE--------SQQPGEQ----DQQLSSGSGQEPQLLIQ----CILLRATQASPVKACYSYMDL 2441
..|| |..|||: |.|:.. .|:.|:. | |||.|. |
Human 2196 DAAELYPCVMFYSSNPGEKVKICDMQMRG----TPRDLLPGDPIC--------SPVAAV-----L 2243
Fly 2442 ATAALN-------------CI-QSLATQAHQE---LSEGGGVPPNGRALSSPPQPTMVHGVPVYN 2489
|.|.:. || :.:..:.|:. :.|.|......|::.|..:..|
Human 2244 AEATIQLIRILHRTDRWTYCINKKMMERLHKIKICIKESGQKLKKSRSVQSREENEM-------- 2300
Fly 2490 VARKEQKPSEQVEQKSK---------------------WPAAAT--------------------- 2512
:|:|.|:: |:|.| ||..|.
Human 2301 ---REEKESKE-EEKGKHTRHGLADLSELQLRTLCIEVWPVLAVIGGVDAGLRVGGRCVHKQTGR 2361
Fly 2513 DAQLIGQIMEMGFTRRTVELALKQLSLQAEIMPTPEQIVQWILE--------------------- 2556
.|.|:|.:.| |.|...|:....::::......:|.....:.||
Human 2362 HATLLGVVKE-GSTSAKVQWDEAEITISFPTFWSPSDTPLYNLEPCEPLPFDVARFRGLTASVLL 2425
Fly 2557 --------HPDVCANTIE----------------------EDTLPLASSASSHDPEADSDNECPS 2591
|.|:...:.: |..|.:.:..:|.|.::.|.....|
Human 2426 DLTYLTGVHEDMGKQSTKRHEKKHRHESEEKGDVEQKPESESALDMRTGLTSDDVKSQSTTSSKS 2490
Fly 2592 SNSTTSSS--TSSDTVEGQPMAVSGPAPPVKFESR------KDFQTADLYALYVRGLVRPGMTVR 2648
.|...|.| .:..:||.|.....|.....:..|: .:.:...|..||: |.::....:.
Human 2491 ENEIASFSLDPTLPSVESQHQITEGKRKNHEHMSKNHDVAQSEIRAVQLSYLYL-GAMKSLSALL 2554
Fly 2649 CCRDFEEIKQGDMGTVLI--VDTEGLHDLNVQVDWRNHGSTYWVC----FVH--IELVEAAQ--- 2702
.|..:.|: :|| |..|..|:.: | .|| :|:..|.|
Human 2555 GCSKYAEL-------LLIPKVLAENGHNSD--------------CASSPVVHEDVEMRAALQFLM 2598
Fly 2703 THHQPR-----PPPIAVGARVRLRTSSLRY-----GML--------------------------C 2731
.|...| |...|:|.....|..::.| |:| .
Human 2599 RHMVKRAVMRSPIKRALGLADLERAQAMIYKLVVHGLLEDQFGGKIKQEIDQQAEESDPAQQAQT 2663
Fly 2732 PLRLGRSQGSSAIGVVSSVRSKQL---------TVDFPDQPAWQGHINEVELVASQPTSATLPSL 2787
|:....|..|:...:.||:..... ||...:.|.........::.:|.||:..||:
Human 2664 PVTTSPSASSTTSFMSSSLEDTTTATTPVTDTETVPASESPGVMPLSLLRQMFSSYPTTTVLPT- 2727
Fly 2788 GDSCSQMPPSDLIEDWSRCIRSLTVSSNEAAAKHLLNGSNQPWQSCSSGPCRHWIRLELHDRILV 2852
..:|.|| |.||..|.::.. |..|...|..|...|...|..|.|
Human 2728 --RRAQTPP----------ISSLPTSPSDEV------GRRQSLTSPDSQSARPANRTALSD---- 2770
Fly 2853 HSLTLKVSPEDHSHMPSLLEIRVGDCVDSLKEYTWIPVPAGASRVLLMQQVPTYYPWVEVVVKQC 2917
.|..|..|| |.||.|..:|.|
Human 2771 PSSRLSTSP---------------------------PPPAIAVPLLEM----------------- 2791
Fly 2918 QNNGIQCK--IHGIKFVGRRQQPDLQHILANAQFLASEYSAGVGPG----STAGAGAVSTSHEEA 2976
|...: ...::..|.|.:.|.|:|...|.::... || ....:|:.:.|...|
Human 2792 ---GFSLRQIAKAMEATGARGEADAQNITVLAMWMIEH------PGHEDEEEPQSGSTADSRPGA 2847
Fly 2977 AAAPEQDLPCTVMVWGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVY 3041
|. || .|.|...|.:.|:...: |...|...:..|..|.|...:
Human 2848 AV--------------------LG--SGGKSNDPCYLQSPGDI-PSADAAEMEEGFSESPDNLDH 2889
Fly 3042 ----ACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGED 3102
|.|.|.:.|....||.. |:..:..:.::.:.| |.:
Human 2890 TENAASGSGPSARGRSAVTRR----HKFDLAARTLLARAA----GLY------------------ 2928
Fly 3103 GKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQ---GELYTWGLGEYGRLGHGDNTT 3164
|.|:|.|.:..|: .||.| |.||.:.|.| :...
Human 2929 --------------RSVQAHRNQSRRE---------GISLQQDPGALYDFNLDE-------ELEI 2963
Fly 3165 QLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTP--H--EI 3225
.|..:.:.|:.|: .||.|..: ||....|..|.| | |.
Human 2964 DLDDEAMEAMFGQ---------------DLTSDNDI----------LGMWIPEVLDWPTWHVCES 3003
Fly 3226 ERLSGIGVVQI-ECG-AQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHV 3288
|....:.|.:: ||. ..| :||:::..|..|....|..:.
Human 3004 EDREEVVVCELCECSVVSF-------------------------NQHMKRNHPGCGRSANRQGYR 3043
Fly 3289 AVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFV--------------------------NKKPA 3327
:.|: .|..|.. |:.||||.:. .:.|.
Human 3044 SNGS----------YVDGWFG---GECGSGNPYYLLCGTCREKYLAMKTKSKSTSSERYKGQAPD 3095
Fly 3328 LVIGLDAVFVNRVACGSSHSIAWGLPNASSDEEKRG---------------------PVPFSSTR 3371
|:...|:|:.. .|.:.:...||:..| ||.|..:
Human 3096 LIGKQDSVYEE----------DWDMLDVDEDEKLTGEEEFELLAGPLGLNDRRIVPEPVQFPDS- 3149
Fly 3372 DPLGGSSLGIYEAETM-QTLKQ-------EAKPLNQSSLSE-SLALETPAARQAALGHVLRAMSI 3427
||||.|...:....:| :||.| |.....:.:|.| :.||..|..|..||..|..|..:
Human 3150 DPLGASVAMVTATNSMEETLMQIGCHGSVEKSSSGRITLGEQAAALANPHDRVVALRRVTAAAQV 3214
Fly 3428 LQARQLIVAALTSHSKVNFKERGAVGGEEDHLIGG------------------------PIMGAP 3468
|.||.:::.||:..| |.|....|..| .:..:|
Human 3215 LLARTMVMRALSLLS---------VSGSSCSLAAGLESLGLTDIRTLVRLMCLAAAGRAGLSTSP 3270
Fly 3469 LQLAETIAQG-GGEAPAD---------ATDAG-LQEHSPEAA-----------VDALTG------ 3505
..:|.|..:. ||.:.|: :|..| |..::|.|| :.|.||
Human 3271 SAMASTSERSRGGHSKANKPISCLAYLSTAVGCLASNAPSAAKLLVQLCTQNLISAATGVNLTTV 3335
Fly 3506 --------------GMS-----------------------GGANTLP------------------ 3515
|:: .||...|
Human 3336 DDSIQRKFLPSFLRGIAEENKLVTSPNFVVTQALVALLADKGAKLRPNYDKSEVEKKGLIAQLYA 3400
Fly 3516 -----PLSAGPLSAFQSLTGSLSMSGSLSSSALPQHK-------------HSRMSASAMSVMA-- 3560
|.:.|||....:| .:..:|..||| ||: |.|.:.:.:..:|
Human 3401 HPSYDPSAVGPLELANAL-AACCLSSRLSS----QHRQWAAQQLVRTLAAHDRDNQTTLQTLADM 3460
Fly 3561 ------ATMTQQEEMLSHISHC-----HGLDDFGGLLGEPE----AKSLVELLKLAVCGR----- 3605
.:..:.|...:.:..| .||....|..|... .|....|.:..|..|
Human 3461 GGDLRKCSFIKLEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWNVTKKQYSLQQTCVFNRLEGDA 3525
Fly 3606 ---CGPPS-----------TSQTIADTL--------ISLGAGT-----------------PAVA- 3630
.|.|| :.:.:|..| ::.|.|. ||.|
Human 3526 EESLGSPSDPSFSPVSWSISGKYLAGALEKMVNIWQVNGGKGLVDIQPHWVSALAWPEEGPATAW 3590
Fly 3631 -----AMLL------ETCITELEDLCTSRHCLGKLPKPVMQESSHPYVDNVNVT----------- 3673
.:|| ...:.|:.|:.|... :|..|.|..:|:||
Human 3591 SGESPELLLVGRMDGSLGLIEVVDVSTMHR----------RELEHCYRKDVSVTCIAWFSEDRPF 3645
Fly 3674 GVVRIPGAEML----RLEFDSQCSTEKRNDPLVIM--DGTGRVLAMRSGRE-------------- 3718
.|....|..:| .||.......:...|.|:.| |.||.:| |...:|
Human 3646 AVGYFDGKLLLGTKEPLEKGGIVLIDAHKDTLISMKWDPTGHIL-MTCAKEDSVKLWGSISGCWC 3709
Fly 3719 ----FAH--------WAPEIRVLGDELR--------------WKFSSD------SSVNGW----- 3746
..| |. .:...|.:|: |:...| :|..||
Human 3710 CLHSLCHPSIVNGIAWC-RLPGKGSKLQLLMATGCQSGLVCVWRIPQDTTQTNVTSAEGWWEQES 3773
Fly 3747 ----GWRFWVHA---------IMPAATLGESGSDRAVLSQPSMALVMSLLDSRLAPRQPSVLLRL 3798
|:|....| |.|..|:..| ||...|....:..:|::...|......:|::..
Human 3774 NCQDGYRKSSGAKCVYQLRGHITPVRTVAFS-SDGLALVSGGLGGLMNIWSLRDGSVLQTVVIGS 3837
Fly 3799 AS----------ALAACSQ-----LGALTTAQRIWSLRKLHAVLLLEQAPRPQD-------PSLS 3841
.: .:||||. |....||: |:... |.:.....|.:.|. |.:.
Human 3838 GAIQTTVWIPEVGVAACSNRSKDVLVVNCTAE--WAAAN-HVLATCRTALKQQGVLGLNMAPCMR 3899
Fly 3842 TLLQPLIPELLRQYEYEEPQVRGGIHLMHSDYFKTLAALACDMQLDAAL---PATSSSSSSSAAP 3903
..|:.|...|..||.||:|.|..|..|:||.|.:.||:||..:.||..| |......:....|
Human 3900 AFLERLPMMLQEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDP 3964
Fly 3904 GAISSTGDVHKWAWFKRYCIAVRVAQSLIRRTELPRAFCLEVRKKFAEMLPSSSSNSNANPGCQS 3968
::.:.::|||.:.:...::.|::|....:.|.:|
Human 3965 ----ASWNPNEWAWLECFSTTIKAAEALTNGAQFPESF--------------------------- 3998
Fly 3969 PGASMLNSTTSLSSSTVSNVSPPPGITGEQPDLHCHAHQLESTSTLLHEDHTLFQAPH------- 4026
||.::.|.| ||..:|...:
Human 3999 ---------------TVPDLEPVP------------------------EDELVFLMDNSKWINGM 4024
Fly 4027 DAQLLQWLNRRPDDWALSWGGASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGE 4091
|.|::.|...||:||.| ||...:|.||....|||. |..| ....|..|.|..:..|:..|:
Human 4025 DEQIMSWATSRPEDWHL--GGKCDVYLWGAGRHGQLA--EAGR-NVMVPAAAPSFSQAQQVICGQ 4084
Fly 4092 QSLFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGK-HCLALTTEG 4155
...|.:..:|.:.|.|.||.||||.|.||...:.|::.:||...|.::..:.|.. |.:|||..|
Human 4085 NCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESG 4149
Fly 4156 EVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRL 4220
||::||:|:.|||||||.....||:.:|.|.|..|..::||..|||.:|:.|.:.|:|.|.||||
Human 4150 EVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRL 4214
Fly 4221 GHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDN-VWSWGDGDYGKLGRGGSDGCKL 4284
|.|::.::..|:.|.||.||:...:|||.. .||.::.|.: ||::|||||||||.|.|.....
Human 4215 GLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSS 4277
Fly 4285 PYKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKII 4349
|.||:.|.|:|:.||.||:||||||||.|.|||:|:.....|..|...:..||:::..|.|..|.
Human 4278 PQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIE 4342
Fly 4350 SIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALS 4414
.:|.|:.|.:|.:.:|:||.||.|.|||||.|....::.|.||..||||::.:::.|..|:.|.:
Human 4343 DVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWT 4407
Fly 4415 TSQLSERLRPLPNP---------PLEYDLVRDLAPEALHARLILLHHFSELVCPCLAMLPISGD- 4469
...:..|...:..| |.:|..:|:::...:.|||.||:|||:|:.....:|.:|.:
Human 4408 APPVPPRAPGVSVPLQLGLPDTVPPQYGALREVSIHTVRARLRLLYHFSDLMYSSWRLLNLSPNN 4472
Fly 4470 -------------LSLGALKDVLVYNIKEAAFRKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCN 4521
:..|.|:.:|...:......:.|..|||:.|.:||.|.:.||.. |.| :|
Human 4473 QNSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRIST-RGR-KC- 4534
Fly 4522 GLAGIDGMKSVFGQMVQKLPLLTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGS 4586
|.:|.|:.:::..|....|.||.|.||||.|||..||.||.:.::|.|||.||:.|.
Human 4535 --------KPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGI 4591
Fly 4587 VPLLINTPNGRGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQL 4651
|.|||.:||...|.|.|||.||.:|:......:..|:|||:|||:|:||..||.::||..||:||
Human 4592 VDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQL 4656
Fly 4652 TGEVLRPTDLTEVDRDYVAGLLCIRNMDD----DPKLFTALEL-PFSTSSARGHEVPL--STRYT 4709
....|...||.|||..||..|..|.:::| :......:.| .|...||.|..||: .....
Human 4657 CCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSI 4721
Fly 4710 HISPRNRAEYVRLALGFRLHEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLL 4774
.::..||.|||..|:.:||||.|.||.|||:|||.::|||||||.:|.:|:.||||.|:|.:.:|
Human 4722 PLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVL 4786
Fly 4775 KSVATYKGFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEKNP 4839
|.|..|:..|....||.|||..:|||:|:||.||:|||.||:|||...||...| .|:::.:.
Human 4787 KKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQR---FQIMKVDR 4848
Fly 4840 PDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAIHFCKSIDTDEY 4884
|...||.|.||||.|::|.||.:.|:.|:|:|||:.|:|||.|.|
Human 4849 PYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMDNY 4893
| 
