Protein Alignment HERC2 and HERC1

DIOPT Version :9

• Sequence 1: NP_608388.2
• Gene: HERC2 / 33035
• FlyBaseID: FBgn0031107
• Length: 4912
• Species: Drosophila melanogaster
• Sequence 2: XP_016878188.1
• Gene: HERC1 / 8925
• HGNCID: 4867
• Length: 4909
• Species: Homo sapiens
• Alignment Length: 5765
• Identity: 1321/5765 - (22%)
• Similarity: 2029/5765 - (35%)
• Gaps: 1826/5765 - (31%)

  Fly    69 PDLYLRPLPFLDAKWLRADLIASLRNAADGAVLWNHLIQDCELVSSPTAPLLNARGQL------S 127
            |.:.|:.|..|::.|:..| ..|:......|||::.|:.:.|:|..|...|.....||      |
Human     6 PPVKLKWLEHLNSSWITED-SESIATREGVAVLYSKLVSNKEVVPLPQQVLCLKGPQLPDFERES 69

  Fly   128 YLGDDGKHYCGAQQLKCSCCQPEYCGPLSACNCDGCRPLDSDTAIKKLTTQAAAQQAAHLSQATD 192
            ...|:..||..|.                         |.|..|:.|:.
Human    70 LSSDEQDHYLDAL-------------------------LSSQLALAKMV---------------- 93

  Fly   193 MVLSGWLWSQPPSQQARLDCQRSMISELQELALRAAGNCLSAQHLRQQLFIYERYFVAL------ 251
                               |..|..                |..||::|.:.:|.|.||
Human    94 -------------------CSDSPF----------------AGALRKRLLVLQRVFYALSNKYHD 123

  Fly   252 KRERERERKSTTSAQAVASVTTANTTIAATTANAAVESQPAEQQAEHGALGLARVATHAALNFSF 316
            |.:.::::.|..|:...|.|.:.:....::| :|.:|                 :.....|:..|
Human   124 KGKVKQQQHSPESSSGSADVHSVSERPRSST-DALIE-----------------MGVRTGLSLLF 170

  Fly   317 AFLRRAWR---SGEDTEMCSELLSEALASLQELPEATLFEAAVVSSLWLEVMERSIKFLRLVAL- 377
            |.||::|.   ||....:|::::..|:..:..||..:|...:.:..:.|:.:.:...||:.|.:
Human   171 ALLRQSWMMPVSGPGLSLCNDVIHTAIEVVSSLPPLSLANESKIPPMGLDCLSQVTTFLKGVTIP 235

  Fly   378 ---GDPMGNRCTAPLNDRHTALCLLLELGVQKGTLAATLECVVLLL------LLWEKDRAGNDNR 433
               .|.:|.|..:.         |||.|..|:|:|...||.:.:.|      ...||.:..:...
Human   236 NSGADTLGRRLASE---------LLLGLAAQRGSLRYLLEWIEMALGASAVVHTMEKGKLLSSQE 291

  Fly   434 -------------DMPRKTGAPLQRILLRYQKIGATAKGGGIAGGEPAPVASATETFLRFLSLPK 485
                         .|.|..|:...|...|                ||.                :
Human   292 GMISFDCFMTILMQMRRSLGSSADRSQWR----------------EPT----------------R 324

  Fly   486 SSAAIVDLRRAAVVIISHLDRMVQPLMPRCL----LRGGQATAASSSSAPQQRIYALGWPSLSKD 546
            :|..:..|..||:.:...:.||.......|.    ::.|.|...|.:.    .:|.  |.|.|..
Human   325 TSDGLCSLYEAALCLFEEVCRMASDYSRTCASPDSIQTGDAPIVSETC----EVYV--WGSNSSH 383

  Fly   547 Q-----QGFSAEPTLSWSGESAGVPTLS----CRFQIK---QVACCETQMLILSQEGKLYTWRLA 599
            |     |....:|.|:.|...|  .|:.    |.|.|.   .|..|          ||....||.
Human   384 QLVEGTQEKILQPKLAPSFSDA--QTIEAGQYCTFVISTDGSVRAC----------GKGSYGRLG 436

  Fly   600 KPEA------EPLPMEEVAHDVFISIAGHCEGRHFLAIDSNHNAYSWGTGEDHRLGHGDTHARAV 658
            ..::      :.|..|.......:|.:...:| |.||..:....:|||.|:..:||||::..:..
Human   437 LGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDG-HTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKY 500

  Fly   659 PTKI-AALEQHCVQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMV 722
            |..| ..|:...|..|..|..:|||:|..|.|.|||.|.:.|||||:|:.|::||||..:|:  |
Human   501 PKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN--V 563

  Fly   723 VDVALGSGDAHSLALTSEG-LVFAWGDGDYGKLGNGNCNGSLQPILVESLPR--VQRVFAGSQFS 784
            .:|:.||  :|::||:.:| .|:::|.||.||||:|:.|...:|.::|:|..  :::|.||||.|
Human   564 GEVSCGS--SHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSS 626

  Fly   785 VALSSEGQLYTWGKATCLGHQLVERSVQGCSVPRLVSSLQHKRIVDVAVSVAHCLALSSSGEVFG 849
            :||:|.||:|.||...|||....|.:...   |:|:..|...|||||::..:||||||...||:.
Human   627 LALTSTGQVYAWGCGACLGCGSSEATALR---PKLIEELAATRIVDVSIGDSHCLALSHDNEVYA 688

  Fly   850 WGRNDSQQICPASVSSEPLLRTPILVSLPTFPASGIACTSAQSLVWT--QSSHQGVPRRAPFVVD 912
            ||.|...| |....|:.|:.:...:..|.......|:..::.||.||  ....|.|....|:.||
Human   689 WGNNSMGQ-CGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWTALPRDRQVVAWHRPYCVD 752

  Fly   913 LGEPTFRLLDQLLGMCSSQDNRQTP------NQESECIAVACLNLFRLQLLALIANGVEPRQVGL 971
            |.|.||..|...|.....:.|.:.|      ::|.......||.|....|...:|.||....:|.
Human   753 LEESTFSHLRSFLERYCDKINSEIPPLPFPSSREHHSFLKLCLKLLSNHLALALAGGVATSILGR 817

  Fly   972 ASGSRLLCSLKTRILGLAGGSQVLRTIQVAAQQALQDGWSVLLPTAAERAQTLTSLLPSEPG--Q 1034
            .:|.  |.:|..|::    .|.|...||....:.|..|.::|||...||.:.|.||||..|.  :
Human   818 QAGP--LRNLLFRLM----DSTVPDEIQEVVIETLSVGATMLLPPLRERMELLHSLLPQGPDRWE 876

  Fly  1035 ASSAGHRFMTDLLVSSLMAEGGLESALQHAIRLE----SSSCSA------------DCGDGVHLP 1083
            :.|.|.|...|::::||.....:.|.|.::...:    ||.|:.            .|....|
Human   877 SLSKGQRMQLDIILTSLQDHTHVASLLGYSSPSDAADLSSVCTGYGNLSDQPYGTQSCHPDTH-- 939

  Fly  1084 LLQLITRLLSNNAALSQTRLSPTLGKQQEK------EEEEREQQHQEPSTSPSLSLLHRFQRLLL 1142
            |.:::.:.|..|......:....|.|..:|      ..|..:..|..       .||...|:.||
Human   940 LAEILMKTLLRNLGFYTDQAFGELEKNSDKFLLGTSSSENSQPAHLH-------ELLCSLQKQLL 997

  Fly  1143 S--HIHQAQPEEETTGAEALLLQYMHALIPACVATLQKAHELALQCREPGENSFGQMVGHLGRVL 1205
            :  ||:..   .|.:.:.|||.:::..|:|.......::..|..:  .|...|.|:   .|..|:
Human   998 AFCHINNI---SENSSSVALLHKHLQLLLPHATDIYSRSANLLKE--SPWNGSVGE---KLRDVI 1054

  Fly  1206 QADISDALLNELLVGLLLLKRD--RPQCLGGLRWARLFLPLLRVLDRLNRALGEGELRDGDDMGW 1268
            ....:.::|.:::..||||...  ||       .....|.||..||.|||.|...:|.:..::.|
Human  1055 YVSAAGSMLCQIVNSLLLLPVSVARP-------LLSYLLDLLPPLDCLNRLLPAADLLEDQELQW 1112

  Fly  1269 PGIICRGGPK----GGPPPADPETHYVRRADMEN--LLLDGSRCIILAGYVCDLSGYNCESETLR 1327
            |   ..|||:    .|.|...|...:|...|:|.  .||.| ||         |.|
Human  1113 P---LHGGPELIDPAGLPLPQPAQSWVWLVDLERTIALLIG-RC---------LGG--------- 1155

  Fly  1328 SVLDSGLGKDLTAEMSSQVHRTAMEHILEHHKLGKYMVQ---ASTEEKSSAPGPSRLTHFSSECA 1389
                                                |:|   .|.||:.:|
Human  1156 ------------------------------------MLQGSPVSPEEQDTA-------------- 1170

  Fly  1390 LAQLLGLVANLMCSGPALQPAELQCRQLDK--SSLLSGGLQLLQPSNPFDEEKGEARSSHSCHST 1452
                ..:...|...|     .|:...||||  |.||...|...:...|||
Human  1171 ----YWMKTPLFSDG-----VEMDTPQLDKCMSCLLEVALSGNEEQKPFD--------------- 1211

  Fly  1453 AGNTPTELPPPLPMQQQLAPGRGKSQLQLRADAFISGLAEARVSEPPVAAWLALTERYCKAHNLM 1517
                 .:|.|.:.:...||.|..|                    ||..:.|:::.: |..:.:
Human  1212 -----YKLRPEIAVYVDLALGCSK--------------------EPARSLWISMQD-YAVSKD-- 1248

  Fly  1518 WHQ-EFATEHPVQELERLLSAVLIRHQYLGGLVLNALETEVPPPRQLGEIIRLVHQAKWSVVRTR 1581
            |.. ..:.|..:..:.|.:.|.|::|..|  |.....|:...|.:.|.|:.|.|::     ||:|
Human  1249 WDSATLSNESLLDTVSRFVLAALLKHTNL--LSQACGESRYQPGKHLSEVYRCVYK-----VRSR 1306

  Fly  1582 QQLNRSYKEVCAPILERLRFLLYEVRPA-ISPQQRGLRRLPILQRPPRFKMLVRRLLQELRSSRQ 1645
            ....::.:.:......|.|::......| :.||:...                      .|:..:
Human  1307 LLACKNLELIQTRSSSRDRWISENQDSADVDPQEHSF----------------------TRTIDE 1349

  Fly  1646 PAKPEDLLNASIQQEQEKKPQSMPKQELEEQEEEETLLR-------------------------- 1684
            .|:.|       :|.:..:.:..|:.|.||:|.|..::.
Human  1350 EAEME-------EQAERDREEGHPEPEDEEEEREHEVMTAGNLVFVLHVTEIFQCFLSAREVARS 1407

  Fly  1685 ----RLNERQIHGEGELDP---ALMQDIVDFALQDSCDVETARRAMYCQMQRYQLRLAGLQIVQQ 1742
                |:|.....|....||   :..:..|...|.:..||.||  |....:.|..|.:.|:..|
Human  1408 RDRDRMNSGAGSGARADDPPPQSQQERRVSTDLPEGQDVYTA--ACNSVIHRCALLILGVSPV-- 1468

  Fly  1743 LLELHGLLDAAQYSLLNGFLGLHLKSTSSGGGSTGSGSSLHVLGQLNMISAYQKARLLLAQSRVL 1807
                   :|..|.....|.|.....|.|.|||......||  ..:..::......||:.::|. .
Human  1469 -------IDELQKRREEGQLQQPSTSASEGGGLMTRSESL--TAESRLVHTSPNYRLIKSRSE-S 1523

  Fly  1808 DWAVRELRRLVNQEQQGHA-RGKDSTNLGTYVLLKRLPRARFLLSVFGLLAKELGPNELGFLINS 1871
            |.:..|      .:::|:| .|:.:.:|.    |....|.|..|.:||    :|.|.:
Human  1524 DLSQPE------SDEEGYALSGRRNVDLD----LAASHRKRVYLLLFG----QLSPRK------- 1567

  Fly  1872 GLLGTVLGLLAQTGGEGATGGQVHGELSILYEDSVLKQKSSKAQL--------SGPDLAKLMKIG 1928
                       :...:....|.:|.:|..| .||..:.|.|:..|        |..||.|.:.:.
Human  1568 -----------KKSFKQVHDGPMHSQLESL-SDSWARLKHSRDWLCNSSYSFESDFDLTKSLGVH 1620

  Fly  1929 TRIVRGADWKWGDQDGNPPG------------EGRIISEVGEDGWVRVEWYTGATNSYRM---GK 1978
            |.|.....:..||. ||.||            :..||:.  |...:|.|....|.:...:   |.
Human  1621 TLIENVVSFVSGDV-GNAPGFKEPEESMSTSPQASIIAM--EQQQLRAELRLEALHQILVLLSGM 1682

  Fly  1979 EGQYDLQLADSALNVASPTEPEREDVSGSEASPTSDSHPSKLLRHC------------------- 2024
            |.:..:.||.|.|:            ||.::|....|...:.|..|
Human  1683 EEKGSISLAGSRLS------------SGFQSSTLLTSVRLQFLAGCFGLGTVGHTGGKGESGRLH 1735

  Fly  2025 -------AAKLLQILAVGTGLH------GAQLDKDALRG------------MTSMFRTIIYPKPS 2064
                   |||....:.:...:|      .|.|:: ||:.            :.::|...::.:|.
Human  1736 HYQDGIRAAKRNIQIEIQVAVHKIYQQLSATLER-ALQANKHHIEAQQRLLLVTVFALSVHYQPV 1799

  Fly  2065 MSNISYALGWLNLGFIRAISGDCPRLCLELSTPGWLSHYLSLLEQPAGNEAGVYRQLHCLRLLQL 2129
            ..:::.:.|.||:         ..:||   .|...|...|.||.:...::.....::...||||:
Human  1800 DVSLAISTGLLNV---------LSQLC---GTDTMLGQPLQLLPKTGVSQLSTALKVASTRLLQI 1852

  Fly  2130 ILAQWGAEEEPRMPALVHQLFATLGRIALHCPGDASLLPTAEGKARVLLTAS------HSGSVAE 2188
            :....|...:...|.:|..|...|          .|.|.....:..||..||      ..|...|
Human  1853 LAITTGTYADKLSPKVVQSLLDLL----------CSQLKNLLSQTGVLHMASFGEGEQEDGEEEE 1907

  Fly  2189 ELV------------ALLRRLHTL--------------------------PSWNPVINSFLAQKL 2215
            :.|            |.||:.|..                          |.|..|:.:..:||.
Human  1908 KKVDSSGETEKKDFRAALRKQHAAELHLGDFLVFLRRVVSSKAIQSKMASPKWTEVLLNIASQKC 1972

  Fly  2216 -------------------------------------------------CVAAELLAEQSHSTAL 2231
                                                             |:....:|:..|:..:
Human  1973 SSGIPLVGNLRTRLLALHVLEAVLPACESGVEDDQMAQIVERLFSLLSDCMWETPIAQAKHAIQI 2037

  Fly  2232 -DSEQVFVLGVLGAMGGHDLRPRVGLHCFHEGSHMVIASFTP-KGRC-------LLAPGGVGSGV 2287
             :.||...|...|.:...|           |...:...||.| |.:|       :|..|..|.|.
Human  2038 KEKEQEIKLQKQGELEEED-----------ENLPIQEVSFDPEKAQCCLVENGQILTHGSGGKGY 2091

  Fly  2288 GFV-----------KVQLPAVMPHLDHTVFSLSRLPMNEM---------LLNAWTVLLYGPAPEL 2332
            |..           |..:.......:.|...:||.|:::.         |..|::..||....:.
Human  2092 GLASTGVTSGCYQWKFYIVKENRGNEGTCVGVSRWPVHDFNHRTTSDMWLYRAYSGNLYHNGEQT 2156

  Fly  2333 RELPSSADGRLDLALLRAQQLQMAVLHTNGVLYRHQVALRRILKQRAPGSIYASPDEP-----DR 2392
            ..|.|...|.....:|                   .:..|.|       |...:.:||     |.
Human  2157 LTLSSFTQGDFITCVL-------------------DMEARTI-------SFGKNGEEPKLAFEDV 2195

  Fly  2393 SDAE--------SQQPGEQ----DQQLSSGSGQEPQLLIQ----CILLRATQASPVKACYSYMDL 2441
            ..||        |..|||:    |.|:..    .|:.|:.    |        |||.|.     |
Human  2196 DAAELYPCVMFYSSNPGEKVKICDMQMRG----TPRDLLPGDPIC--------SPVAAV-----L 2243

  Fly  2442 ATAALN-------------CI-QSLATQAHQE---LSEGGGVPPNGRALSSPPQPTMVHGVPVYN 2489
            |.|.:.             || :.:..:.|:.   :.|.|......|::.|..:..|
Human  2244 AEATIQLIRILHRTDRWTYCINKKMMERLHKIKICIKESGQKLKKSRSVQSREENEM-------- 2300

  Fly  2490 VARKEQKPSEQVEQKSK---------------------WPAAAT--------------------- 2512
               :|:|.|:: |:|.|                     ||..|.
Human  2301 ---REEKESKE-EEKGKHTRHGLADLSELQLRTLCIEVWPVLAVIGGVDAGLRVGGRCVHKQTGR 2361

  Fly  2513 DAQLIGQIMEMGFTRRTVELALKQLSLQAEIMPTPEQIVQWILE--------------------- 2556
            .|.|:|.:.| |.|...|:....::::......:|.....:.||
Human  2362 HATLLGVVKE-GSTSAKVQWDEAEITISFPTFWSPSDTPLYNLEPCEPLPFDVARFRGLTASVLL 2425

  Fly  2557 --------HPDVCANTIE----------------------EDTLPLASSASSHDPEADSDNECPS 2591
                    |.|:...:.:                      |..|.:.:..:|.|.::.|.....|
Human  2426 DLTYLTGVHEDMGKQSTKRHEKKHRHESEEKGDVEQKPESESALDMRTGLTSDDVKSQSTTSSKS 2490

  Fly  2592 SNSTTSSS--TSSDTVEGQPMAVSGPAPPVKFESR------KDFQTADLYALYVRGLVRPGMTVR 2648
            .|...|.|  .:..:||.|.....|.....:..|:      .:.:...|..||: |.::....:.
Human  2491 ENEIASFSLDPTLPSVESQHQITEGKRKNHEHMSKNHDVAQSEIRAVQLSYLYL-GAMKSLSALL 2554

  Fly  2649 CCRDFEEIKQGDMGTVLI--VDTEGLHDLNVQVDWRNHGSTYWVC----FVH--IELVEAAQ--- 2702
            .|..:.|:       :||  |..|..|:.:              |    .||  :|:..|.|
Human  2555 GCSKYAEL-------LLIPKVLAENGHNSD--------------CASSPVVHEDVEMRAALQFLM 2598

  Fly  2703 THHQPR-----PPPIAVGARVRLRTSSLRY-----GML--------------------------C 2731
            .|...|     |...|:|.....|..::.|     |:|                          .
Human  2599 RHMVKRAVMRSPIKRALGLADLERAQAMIYKLVVHGLLEDQFGGKIKQEIDQQAEESDPAQQAQT 2663

  Fly  2732 PLRLGRSQGSSAIGVVSSVRSKQL---------TVDFPDQPAWQGHINEVELVASQPTSATLPSL 2787
            |:....|..|:...:.||:.....         ||...:.|.........::.:|.||:..||:
Human  2664 PVTTSPSASSTTSFMSSSLEDTTTATTPVTDTETVPASESPGVMPLSLLRQMFSSYPTTTVLPT- 2727

  Fly  2788 GDSCSQMPPSDLIEDWSRCIRSLTVSSNEAAAKHLLNGSNQPWQSCSSGPCRHWIRLELHDRILV 2852
              ..:|.||          |.||..|.::..      |..|...|..|...|...|..|.|
Human  2728 --RRAQTPP----------ISSLPTSPSDEV------GRRQSLTSPDSQSARPANRTALSD---- 2770

  Fly  2853 HSLTLKVSPEDHSHMPSLLEIRVGDCVDSLKEYTWIPVPAGASRVLLMQQVPTYYPWVEVVVKQC 2917
            .|..|..||                           |.||.|..:|.|
Human  2771 PSSRLSTSP---------------------------PPPAIAVPLLEM----------------- 2791

  Fly  2918 QNNGIQCK--IHGIKFVGRRQQPDLQHILANAQFLASEYSAGVGPG----STAGAGAVSTSHEEA 2976
               |...:  ...::..|.|.:.|.|:|...|.::...      ||    ....:|:.:.|...|
Human  2792 ---GFSLRQIAKAMEATGARGEADAQNITVLAMWMIEH------PGHEDEEEPQSGSTADSRPGA 2847

  Fly  2977 AAAPEQDLPCTVMVWGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVY 3041
            |.                    ||  .|.|...|.:.|:...: |...|...:..|..|.|...:
Human  2848 AV--------------------LG--SGGKSNDPCYLQSPGDI-PSADAAEMEEGFSESPDNLDH 2889

  Fly  3042 ----ACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGED 3102
                |.|.|.:.|....||..    |:..:..:.::.:.|    |.:
Human  2890 TENAASGSGPSARGRSAVTRR----HKFDLAARTLLARAA----GLY------------------ 2928

  Fly  3103 GKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQ---GELYTWGLGEYGRLGHGDNTT 3164
                          |.|:|.|.:..|:         .||.|   |.||.:.|.|       :...
Human  2929 --------------RSVQAHRNQSRRE---------GISLQQDPGALYDFNLDE-------ELEI 2963

  Fly  3165 QLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTP--H--EI 3225
            .|..:.:.|:.|:               .||.|..:          ||....|..|.|  |  |.
Human  2964 DLDDEAMEAMFGQ---------------DLTSDNDI----------LGMWIPEVLDWPTWHVCES 3003

  Fly  3226 ERLSGIGVVQI-ECG-AQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHV 3288
            |....:.|.:: ||. ..|                         :||:::..|..|....|..:.
Human  3004 EDREEVVVCELCECSVVSF-------------------------NQHMKRNHPGCGRSANRQGYR 3043

  Fly  3289 AVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFV--------------------------NKKPA 3327
            :.|:          .|..|..   |:.||||.:.                          .:.|.
Human  3044 SNGS----------YVDGWFG---GECGSGNPYYLLCGTCREKYLAMKTKSKSTSSERYKGQAPD 3095

  Fly  3328 LVIGLDAVFVNRVACGSSHSIAWGLPNASSDEEKRG---------------------PVPFSSTR 3371
            |:...|:|:..          .|.:.:...||:..|                     ||.|..:
Human  3096 LIGKQDSVYEE----------DWDMLDVDEDEKLTGEEEFELLAGPLGLNDRRIVPEPVQFPDS- 3149

  Fly  3372 DPLGGSSLGIYEAETM-QTLKQ-------EAKPLNQSSLSE-SLALETPAARQAALGHVLRAMSI 3427
            ||||.|...:....:| :||.|       |.....:.:|.| :.||..|..|..||..|..|..:
Human  3150 DPLGASVAMVTATNSMEETLMQIGCHGSVEKSSSGRITLGEQAAALANPHDRVVALRRVTAAAQV 3214

  Fly  3428 LQARQLIVAALTSHSKVNFKERGAVGGEEDHLIGG------------------------PIMGAP 3468
            |.||.:::.||:..|         |.|....|..|                        .:..:|
Human  3215 LLARTMVMRALSLLS---------VSGSSCSLAAGLESLGLTDIRTLVRLMCLAAAGRAGLSTSP 3270

  Fly  3469 LQLAETIAQG-GGEAPAD---------ATDAG-LQEHSPEAA-----------VDALTG------ 3505
            ..:|.|..:. ||.:.|:         :|..| |..::|.||           :.|.||
Human  3271 SAMASTSERSRGGHSKANKPISCLAYLSTAVGCLASNAPSAAKLLVQLCTQNLISAATGVNLTTV 3335

  Fly  3506 --------------GMS-----------------------GGANTLP------------------ 3515
                          |::                       .||...|
Human  3336 DDSIQRKFLPSFLRGIAEENKLVTSPNFVVTQALVALLADKGAKLRPNYDKSEVEKKGLIAQLYA 3400

  Fly  3516 -----PLSAGPLSAFQSLTGSLSMSGSLSSSALPQHK-------------HSRMSASAMSVMA-- 3560
                 |.:.|||....:| .:..:|..|||    ||:             |.|.:.:.:..:|
Human  3401 HPSYDPSAVGPLELANAL-AACCLSSRLSS----QHRQWAAQQLVRTLAAHDRDNQTTLQTLADM 3460

  Fly  3561 ------ATMTQQEEMLSHISHC-----HGLDDFGGLLGEPE----AKSLVELLKLAVCGR----- 3605
                  .:..:.|...:.:..|     .||....|..|...    .|....|.:..|..|
Human  3461 GGDLRKCSFIKLEAHQNRVMTCVWCNKKGLLATSGNDGTIRVWNVTKKQYSLQQTCVFNRLEGDA 3525

  Fly  3606 ---CGPPS-----------TSQTIADTL--------ISLGAGT-----------------PAVA- 3630
               .|.||           :.:.:|..|        ::.|.|.                 ||.|
Human  3526 EESLGSPSDPSFSPVSWSISGKYLAGALEKMVNIWQVNGGKGLVDIQPHWVSALAWPEEGPATAW 3590

  Fly  3631 -----AMLL------ETCITELEDLCTSRHCLGKLPKPVMQESSHPYVDNVNVT----------- 3673
                 .:||      ...:.|:.|:.|...          :|..|.|..:|:||
Human  3591 SGESPELLLVGRMDGSLGLIEVVDVSTMHR----------RELEHCYRKDVSVTCIAWFSEDRPF 3645

  Fly  3674 GVVRIPGAEML----RLEFDSQCSTEKRNDPLVIM--DGTGRVLAMRSGRE-------------- 3718
            .|....|..:|    .||.......:...|.|:.|  |.||.:| |...:|
Human  3646 AVGYFDGKLLLGTKEPLEKGGIVLIDAHKDTLISMKWDPTGHIL-MTCAKEDSVKLWGSISGCWC 3709

  Fly  3719 ----FAH--------WAPEIRVLGDELR--------------WKFSSD------SSVNGW----- 3746
                ..|        |. .:...|.:|:              |:...|      :|..||
Human  3710 CLHSLCHPSIVNGIAWC-RLPGKGSKLQLLMATGCQSGLVCVWRIPQDTTQTNVTSAEGWWEQES 3773

  Fly  3747 ----GWRFWVHA---------IMPAATLGESGSDRAVLSQPSMALVMSLLDSRLAPRQPSVLLRL 3798
                |:|....|         |.|..|:..| ||...|....:..:|::...|......:|::..
Human  3774 NCQDGYRKSSGAKCVYQLRGHITPVRTVAFS-SDGLALVSGGLGGLMNIWSLRDGSVLQTVVIGS 3837

  Fly  3799 AS----------ALAACSQ-----LGALTTAQRIWSLRKLHAVLLLEQAPRPQD-------PSLS 3841
            .:          .:||||.     |....||:  |:... |.:.....|.:.|.       |.:.
Human  3838 GAIQTTVWIPEVGVAACSNRSKDVLVVNCTAE--WAAAN-HVLATCRTALKQQGVLGLNMAPCMR 3899

  Fly  3842 TLLQPLIPELLRQYEYEEPQVRGGIHLMHSDYFKTLAALACDMQLDAAL---PATSSSSSSSAAP 3903
            ..|:.|...|..||.||:|.|..|..|:||.|.:.||:||..:.||..|   |......:....|
Human  3900 AFLERLPMMLQEQYAYEKPHVVCGDQLVHSPYMQCLASLAVGLHLDQLLCNPPVPPHHQNCLPDP 3964

  Fly  3904 GAISSTGDVHKWAWFKRYCIAVRVAQSLIRRTELPRAFCLEVRKKFAEMLPSSSSNSNANPGCQS 3968
                ::.:.::|||.:.:...::.|::|....:.|.:|
Human  3965 ----ASWNPNEWAWLECFSTTIKAAEALTNGAQFPESF--------------------------- 3998

  Fly  3969 PGASMLNSTTSLSSSTVSNVSPPPGITGEQPDLHCHAHQLESTSTLLHEDHTLFQAPH------- 4026
                           ||.::.|.|                        ||..:|...:
Human  3999 ---------------TVPDLEPVP------------------------EDELVFLMDNSKWINGM 4024

  Fly  4027 DAQLLQWLNRRPDDWALSWGGASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGE 4091
            |.|::.|...||:||.|  ||...:|.||....|||.  |..| ....|..|.|..:..|:..|:
Human  4025 DEQIMSWATSRPEDWHL--GGKCDVYLWGAGRHGQLA--EAGR-NVMVPAAAPSFSQAQQVICGQ 4084

  Fly  4092 QSLFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGK-HCLALTTEG 4155
            ...|.:..:|.:.|.|.||.||||.|.||...:.|::.:||...|.::..:.|.. |.:|||..|
Human  4085 NCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESG 4149

  Fly  4156 EVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRL 4220
            ||::||:|:.|||||||.....||:.:|.|.|..|..::||..|||.:|:.|.:.|:|.|.||||
Human  4150 EVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRL 4214

  Fly  4221 GHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDN-VWSWGDGDYGKLGRGGSDGCKL 4284
            |.|::.::..|:.|.||.||:...:|||..  .||.::.|.: ||::|||||||||.|.|.....
Human  4215 GLGNTSNKKLPERVTALEGYQIGQVACGLN--HTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSS 4277

  Fly  4285 PYKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKII 4349
            |.||:.|.|:|:.||.||:||||||||.|.|||:|:.....|..|...:..||:::..|.|..|.
Human  4278 PQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIE 4342

  Fly  4350 SIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALS 4414
            .:|.|:.|.:|.:.:|:||.||.|.|||||.|....::.|.||..||||::.:::.|..|:.|.:
Human  4343 DVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWT 4407

  Fly  4415 TSQLSERLRPLPNP---------PLEYDLVRDLAPEALHARLILLHHFSELVCPCLAMLPISGD- 4469
            ...:..|...:..|         |.:|..:|:::...:.|||.||:|||:|:.....:|.:|.:
Human  4408 APPVPPRAPGVSVPLQLGLPDTVPPQYGALREVSIHTVRARLRLLYHFSDLMYSSWRLLNLSPNN 4472

  Fly  4470 -------------LSLGALKDVLVYNIKEAAFRKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCN 4521
                         :..|.|:.:|...:......:.|..|||:.|.:||.|.:.||.. |.| :|
Human  4473 QNSTSHYNAGTWGIVQGQLRPLLAPRVYTLPMVRSIGKTMVQGKNYGPQITVKRIST-RGR-KC- 4534

  Fly  4522 GLAGIDGMKSVFGQMVQKLPLLTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGS 4586
                    |.:|.|:.:::..|....|.||.|.||||.|||..||.||.:.::|.|||.||:.|.
Human  4535 --------KPIFVQIARQVVKLNASDLRLPSRAWKVKLVGEGADDAGGVFDDTITEMCQELETGI 4591

  Fly  4587 VPLLINTPNGRGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQL 4651
            |.|||.:||...|.|.|||.||.:|:......:..|:|||:|||:|:||..||.::||..||:||
Human  4592 VDLLIPSPNATAEVGYNRDRFLFNPSACLDEHLMQFKFLGILMGVAIRTKKPLDLHLAPLVWKQL 4656

  Fly  4652 TGEVLRPTDLTEVDRDYVAGLLCIRNMDD----DPKLFTALEL-PFSTSSARGHEVPL--STRYT 4709
            ....|...||.|||..||..|..|.:::|    :......:.| .|...||.|..||:  .....
Human  4657 CCVPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMVPIIPGGNSI 4721

  Fly  4710 HISPRNRAEYVRLALGFRLHEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLL 4774
            .::..||.|||..|:.:||||.|.||.|||:|||.::|||||||.:|.:|:.||||.|:|.:.:|
Human  4722 PLTFSNRKEYVERAIEYRLHEMDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPEISVEVL 4786

  Fly  4775 KSVATYKGFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEKNP 4839
            |.|..|:..|....||.|||..:|||:|:||.||:|||.||:|||...||...|   .|:::.:.
Human  4787 KKVVRYREVDEQHQLVQWFWHTLEEFSNEERVLFMRFVSGRSRLPANTADISQR---FQIMKVDR 4848

  Fly  4840 PDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAIHFCKSIDTDEY 4884
            |...||.|.||||.|::|.||.:.|:.|:|:|||:.|:|||.|.|
Human  4849 PYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDMDNY 4893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826	16/45 (36%)
		RCC1	687..737	CDD:278826	23/49 (47%)
		RCC1	740..787	CDD:278826	20/49 (41%)
		RCC1	790..841	CDD:278826	20/50 (40%)
		RCC1_2	828..857	CDD:290274	15/28 (54%)
		Cyt-b5	1290..1363	CDD:278597	10/74 (14%)
		MIB_HERC2	1928..1987	CDD:284184	16/73 (22%)
		UBA_HERC2	2515..2559	CDD:270585	10/72 (14%)
		Cul7	2624..2699	CDD:288381	15/88 (17%)
		APC10-HERC2	2762..2932	CDD:176485	32/171 (19%)
		RCC1	3037..3088	CDD:278826	10/54 (19%)
		RCC1	3091..3140	CDD:278826	5/48 (10%)
		RCC1	3144..3194	CDD:278826	8/49 (16%)
		RCC1	3197..3246	CDD:278826	13/54 (24%)
		RCC1	3250..3298	CDD:278826	6/47 (13%)
		RCC1	3302..3350	CDD:278826	11/73 (15%)
		RCC1_2	4136..4166	CDD:290274	12/30 (40%)
		RCC1	4154..4203	CDD:278826	24/48 (50%)
		RCC1	4206..4257	CDD:278826	21/50 (42%)
		RCC1	4260..4309	CDD:278826	28/49 (57%)
		RCC1	4312..4360	CDD:278826	15/47 (32%)
		RCC1	4364..4413	CDD:278826	21/48 (44%)
		HECTc	4509..4880	CDD:238033	165/377 (44%)
		HECTc	4553..4878	CDD:214523	152/331 (46%)
HERC1	XP_016878188.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102650
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720