|
Fly 79 LDAKWLRADL-IASLRNAADGAVLWNHLIQDCELVSSPTAPLLNARGQLSYLGDDGKHYCGAQQL 142
||:|||:.|: :|..|:...| |||.:::|.|:|.:.|....| |:|....||.....|.::
Human 14 LDSKWLKTDIQLAFTRDGLCG--LWNEMVKDGEIVYTGTESTQN--GELPPRKDDSVEPSGTKK- 73
Fly 143 KCSCCQPEYCGPLSACNCDGCRPLDSDTAIKKLTTQAAAQQAAHLSQATDMVLSGWLWSQPPSQQ 207
..|:......:..|.|...:| ..:|..|:|.:.|...
Human 74 ---------------------EDLNDKEKKDEEETPAPIYRA-------KSILDSWVWGKQPDVN 110
Fly 208 ARLDCQRSMISELQELALRAAGNCLSAQHLRQQLFIYERYFVALKRERERERKSTTSAQAVASVT 272
...:|...::.|.|.||:::|...|||..|:|:|.|.||||:||.| |
Human 111 ELKECLSVLVKEQQALAVQSATTTLSALRLKQRLVILERYFIALNR------------------T 157
Fly 273 TANTTIAATTANAAVESQPAEQQ----AEHGALGLARVATHAALNFSFAFLRRAWRSGEDTEMCS 333
.....:.....::.:...|.::: |..|..|||||.:.|||:|:|||||||||||||.::||
Human 158 VFQENVKVKWKSSGISLPPVDKKSSRPAGKGVEGLARVGSRAALSFAFAFLRRAWRSGEDADLCS 222
Fly 334 ELLSEALASLQELPEATLFEAAVVSSLWLEVMERSIKFLRLVALGDPMGNRCT-----APLNDRH 393
|||.|:|.:|:.||||:||:.:.|||:||||:||:.:|||.|..||..|...| .||.|:|
Human 223 ELLQESLDALRALPEASLFDESTVSSVWLEVVERATRFLRSVVTGDVHGTPATKGPGSIPLQDQH 287
Fly 394 TALCLLLELGVQKGTLAATLECVVLLLLLWEKDRAGNDNRDMPRKTGAPLQRILLRYQKIGATAK 458
.||.:||||.||:|||:..|..::|||.||:......||....:.|.|||..:|.|:|.| ...|
Human 288 LALAILLELAVQRGTLSQMLSAILLLLQLWDSGAQETDNERSAQGTSAPLLPLLQRFQSI-ICRK 351
Fly 459 GGGIAGGE----PAPVASATETFLRFLSLPKSSAAIVDLRRAAVVIISHLDRMVQPLMPRCLLRG 519
....:.|: ..|: |..|:|||:|:||:.:...:|||:.|||:::||||:..|.||..
Human 352 DAPHSEGDMHLLSGPL-SPNESFLRYLTLPQDNELAIDLRQTAVVVMAHLDRLATPCMPPL---- 411
Fly 520 GQATAASSSSAPQQRIYALGWPSLSKDQQGFSAEPTLSWSGESAGVPTLSC----RFQIKQVACC 580
.::.:|.....|.: :|| ..:.|...:..:..:.| ...:.|:||.
Human 412 --CSSPTSHKGSLQEV--IGW-------------GLIGWKYYANVIGPIQCEGLANLGVTQIACA 459
Fly 581 ETQMLILSQEGKLYTWRLAKPEAEPLPMEEVAHDVFISIAGHCEGRHFLAIDSNHNAYSWGTGED 645
|.:.||||:.|::||.........|..::.:|....:.||.|.:|.|:||:.:....||||.|:.
Human 460 EKRFLILSRNGRVYTQAYNSDTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDG 524
Fly 646 HRLGHGDTHARAVPTKIAALE-----QHCVQSVYCGCSYSAAITCGGNLLTWGRGTYARLGHGNS 705
.|||||||.....|..|:|.. :|.|. :.||.:||||||..|.|.|||||.|.|||||:|
Human 525 GRLGHGDTVPLEEPKVISAFSGKQAGKHVVH-IACGSTYSAAITAEGELYTWGRGNYGRLGHGSS 588
Fly 706 DDRSLPTLVVALSDHMVVDVALGSGDAHSLALTSEGLVFAWGDGDYGKLGNGNCNGSLQPILVES 770
:|.::|.||..|....|:|||.|||||.:||:|..|.|::||||||||||.|..:|...|.|:|.
Human 589 EDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEK 653
Fly 771 LP--RVQRVFAGSQFSVALSSEGQLYTWGKA--TCLGHQLVERSVQGCSVPRLVSSLQHKRIVDV 831
|. .|.:|..|||||:||:.:||:|:|||. ..|||...|. ...|:|:..||.|:::||
Human 654 LQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEH----VRYPKLLEGLQGKKVIDV 714
Fly 832 AVSVAHCLALSSSGEVFGWGRNDSQQICPASVSSEPLLRTPILVSLPTFPASGIACTSAQSLVWT 896
|....|||||:...||..||.||..|.......::| ....|..|.|....||||..|||..|:
Human 715 AAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKP--EPAALPGLDTKHIVGIACGPAQSFAWS 777
Fly 897 QSSHQGVPRRAPFVVDLGEPTFRLLDQLL-----GMCSSQDNRQTPNQESECIAVACLNLFRLQL 956
..|...:..|.|||||:...||..||.|| ||..|.| ..|.||.||:|||.|||.||||
Human 778 SCSEWSIGLRVPFVVDICSMTFEQLDLLLRQVSEGMDGSAD--WPPPQEKECVAVATLNLLRLQL 840
Fly 957 LALIANGVEPRQVGLASGSRLLCSLKTRILGLAGGSQVLRTIQVAAQQALQDGWSVLLPTAAERA 1021
.|.|::.|:|..:||..||.||.|||..::.||..:.||.|:|.|||..||.|||||||||.|||
Human 841 HAAISHQVDPEFLGLGLGSILLNSLKQTVVTLASSAGVLSTVQSAAQAVLQSGWSVLLPTAEERA 905
Fly 1022 QTLTSLLP---SEPGQASSAGHRFMTDLLVSSLMAEGGLESALQHAIRLE--------------- 1068
:.|::||| |......|.|.|||.||||.||||:|||||||..||..|
Human 906 RALSALLPCAVSGNEVNISPGRRFMIDLLVGSLMADGGLESALHAAITAEIQDIEAKKEAQKEKE 970
Fly 1069 ---------------------------SSSCSADCGDGVHLPLLQLITRLLSNNAALSQTRLSPT 1106
..|....| |||:|||.:||.|.|:.:..||...
Human 971 IDEQEANASTFHRSRTPLDKDLINTGICESSGKQC-----LPLVQLIQQLLRNIASQTVARLKDV 1030
Fly 1107 ---LGKQQEKEEEEREQQHQEPSTSPSLSLLHRFQRLLLSHIHQAQPEEETT--------GAEAL 1160
:....:.|:..||: |.||.||.||||||:|.::..:...:|: |..:|
Human 1031 ARRISSCLDFEQHSRER-------SASLDLLLRFQRLLISKLYPGESIGQTSDISSPELMGVGSL 1088
Fly 1161 LLQYMHAL---------IPACVATLQKAHELALQCREPGENSFGQMVGHLGRVLQADISDALLNE 1216
|.:|...| :.|.:|:....| ...:..:::.|.:..||.|
Human 1089 LKKYTALLCTHIGDILPVAASIASTSWRH-----------------FAEVAYIVEGDFTGVLLPE 1136
Fly 1217 LLVGLLLL---------KRDRPQCLGGLRWARLFLPLLRVLDRLNRALGEGELRDGDDMGWPGII 1272
|:|.::|| :......||| ||..|||.|......|..|.:::.||||:
Human 1137 LVVSIVLLLSKNAGLMQEAGAVPLLGG---------LLEHLDRFNHLAPGKERDDHEELAWPGIM 1192
Fly 1273 --------CRGGPKGGPPPADPETHYVRRADMENLLLDGSRCIILAGYVCDLSGYNCESETLRSV 1329
||. :.|...:|:||:||...||....::.|.|.|:..:..:|.|..|:
Human 1193 ESFFTGQNCRN---------NEEVTLIRKADLENHNKDGGFWTVIDGKVYDIKDFQTQSLTGNSI 1248
Fly 1330 LDSGLGKD----LTAEMSSQVHRTAMEHILEHHKLGKYMVQASTEEKSSAPGPSRLTH--FSSEC 1388
|....|:| |.|.:..:..|.:|.... :|:|: ...:|..:.|....|:. ..:|.
Human 1249 LAQFAGEDPVVALEAALQFEDTRESMHAFC----VGQYL--EPDQEIVTIPDLGSLSSPLIDTER 1307
Fly 1389 ALAQLLGLVANLMCSGPALQPAELQCRQLDKSSLLSGGLQLLQPSNPFDEEKGEARSSHSCHSTA 1453
.|..||||.|:.:.....|.|.|::|.:..:||:.|||||..|....::|||.| .| | |:.
Human 1308 NLGLLLGLHASYLAMSTPLSPVEIECAKWLQSSIFSGGLQTSQIHYSYNEEKDE---DH-C-SSP 1367
Fly 1454 GNTPTELPPPLPMQQQLAPGRGKSQLQLRADAFISGLAEARVSEPPVAAWLALTERYCKAHNLMW 1518
|.||.. :.:|...| ..|...:.||:..:|:..:.:..|..:|...||||:..:|..
Human 1368 GGTPAS-------KSRLCSHR--RALGDHSQAFLQAIADNNIQDHNVKDFLCQIERYCRQCHLTT 1423
Fly 1519 HQEFATEHPVQELERLLSAVLIRHQYLGGLVLN-----ALETEVPP----PRQLGEIIRLVHQAK 1574
...|..||||:|:.|||...|::|:.||.:.|: ||..|... |:.:.::.|:|:|||
Human 1424 PIMFPPEHPVEEVGRLLLCCLLKHEDLGHVALSLVHAGALGIEQVKHRTLPKSVVDVCRVVYQAK 1488
Fly 1575 WSVVRTRQQLNRSYKEVCAPILERLRFLLYEVRPAISPQQRGLRRLPILQRPPRFKMLVRRLLQE 1639
.|:::|.|:..|||||||||::||||||..|:|||:......:.:..:|...||::.:.:::::|
Human 1489 CSLIKTHQEQGRSYKEVCAPVIERLRFLFNELRPAVCNDLSIMSKFKLLSSLPRWRRIAQKIIRE 1553
Fly 1640 LRSSRQPAKPE-------------DLLNASIQQEQ----EKKPQSM--PKQELEEQEEEETLLRR 1685
.|..|.|.||| ||..|.|.... :|:|.:: ||.:.:......|.:.:
Human 1554 RRKKRVPKKPESTDDEEKIGNEESDLEEACILPHSPINVDKRPIAIKSPKDKWQPLLSTVTGVHK 1618
Fly 1686 LN--ERQIHGEGELDPALMQDIVDFAL-QDSCDVETARRAMYCQMQRYQLRLAGLQIVQQLLELH 1747
.. ::.:.|.....| |:..|.:||| ::..|||..|:.:..|::|.::||.|:..:.:|...:
Human 1619 YKWLKQNVQGLYPQSP-LLSTIAEFALKEEPVDVEKMRKCLLKQLERAEVRLEGIDTILKLASKN 1682
Fly 1748 GLLDAAQYSLLNGFLGLHLKSTSSGGGSTGSGSSLHVLGQLNMISAYQKARLLLAQSRVLDWAVR 1812
.||.:.||::..|:..|..:....|...| ..|..:::|..:.:..|.:...::..|||:
Human 1683 FLLPSVQYAMFCGWQRLIPEGIDIGEPLT------DCLKDVDLIPPFNRMLLEVTFGKLYAWAVQ 1741
Fly 1813 ELRRLVNQEQQGHARGKD-----------------STNLGTYVLLKRLPRARFLLSVFGLLAKEL 1860
.:|.:: ....|:.|: ..:||| :|:|||||.:..:|..:.
Human 1742 NIRNVL---MDASAKFKELGIQPVPLQTITNENPSGPSLGT------IPQARFLLVMLSMLTLQH 1797
Fly 1861 GPNELGFLINSGLLG---TVLGLLAQT--GGEGATGGQVHGELSILYEDSVLKQKSSKAQL--SG 1918
|.|.|..|:|||:|. |.|.|:..: ..|........|..:.:.|:: :::::..|| ||
Human 1798 GANNLDLLLNSGMLALTQTALRLIGPSCDNVEEDMNASAQGASATVLEET--RKETAPVQLPVSG 1860
Fly 1919 PDLAKLMKIGTRIVRGADWKWGDQDGNPPGEGRIISEVGEDGWVRVEWYTGATNSYRMGKEGQYD 1983
|:||.:||||||::||.|||||||||.|||.||:|.|:|||||:||:|.||:||||||||||:||
Human 1861 PELAAMMKIGTRVMRGVDWKWGDQDGPPPGLGRVIGELGEDGWIRVQWDTGSTNSYRMGKEGKYD 1925
Fly 1984 LQLADSALNVASPTEPEREDVSGSEASPTS-DSHPSKLLRHCAAKLLQILAVGTGLHGAQLDKDA 2047
|:||:... .|.|:..:.:....|||..|. :.||:.::......|||.|.:..|:|...:..:|
Human 1926 LKLAELPA-AAQPSAEDSDTEDDSEAEQTERNIHPTAMMFTSTINLLQTLCLSAGVHAEIMQSEA 1989
Fly 2048 LRGMTSMFRTII----YPKPSMSN-ISYA---LGWLNLGFIRAISGDCPRLCLELSTPGWLSHYL 2104
.:.:..:.|.:: ..|.|..| :.|. ..|..|||:|:|: ..|::|..||:|.|::..:
Human 1990 TKTLCGLLRMLVESGTTDKTSSPNRLVYREQHRSWCTLGFVRSIA-LTPQVCGALSSPQWITLLM 2053
Fly 2105 SLLEQPAGNEA-GVYRQLHCLRLLQLILAQWGAEEEPR-MPALVHQLFATLGRIALHCPGDASLL 2167
.::|..|...| .:.||:..:.|||.:|..|...|..| |..||.:||..||.:...|..|..||
Human 2054 KVVEGHAPFTATSLQRQILAVHLLQAVLPSWDKTERARDMKCLVEKLFDFLGSLLTTCSSDVPLL 2118
Fly 2168 PTAEGKAR-----VLLTASHSGSVAEELVALLRRLHTLPSWNPVINSFLAQKL-CVAAELLAEQS 2226
..:..:.| ..|||:||.::|||:|||||.||:|..||.:||.::..:| .:....:...|
Human 2119 RESTLRRRRVRPQASLTATHSSTLAEEVVALLRTLHSLTQWNGLINKYINSQLRSITHSFVGRPS 2183
Fly 2227 HSTAL-----DSEQVFV---LGVLGAMGGHDLRPRVGLHCFH----EGSHMVIASFTPKGR---- 2275
....| |||...| :.||..:||.|.|.|:|....| ||: :...||||:
Human 2184 EGAQLEDYFPDSENPEVGGLMAVLAVIGGIDGRLRLGGQVMHDEFGEGT---VTRITPKGKITVQ 2245
Fly 2276 ------CLLAPGGVGSGVGFVKVQLPAVMPHLDHTVFSLSRLPMNEMLLNAWTVL--LYGPAPEL 2332
|.:.| :..:| .|||| .|:::.||..|.:|:.|..| |.|...|.
Human 2246 FSDMRTCRVCP------LNQLK-PLPAV-------AFNVNNLPFTEPMLSVWAQLVNLAGSKLEK 2296
Fly 2333 RELPSSAD----GRLDLALLRAQQLQMAVLHTNGVLYRHQVALRRILKQRA---PGSIYASPD-- 2388
.::..|.. |::||.|||.|||::.:|.....|..||..||:||.|.| .|:::....
Human 2297 HKIKKSTKQAFAGQVDLDLLRCQQLKLYILKAGRALLSHQDKLRQILSQPAVQETGTVHTDDGAV 2361
Fly 2389 -EPDRSDAESQQPGEQDQQLSSGSGQEPQLLIQCILLRATQASPVKACYSYMDLATAALNCIQSL 2452
.||..|...:.| |.|.:|:|.:|..|||.|||||.:...:|..|||...|.|
Human 2362 VSPDLGDMSPEGP------------QPPMILLQQLLASATQPSPVKAIFDKQELEAAALAVCQCL 2414
Fly 2453 ATQAHQELSEGGGVPPNGRALSSPPQPTMVHGVPVYNVARKEQKPSEQVEQKSKWPAAATDAQLI 2517
|.::....|.|. ...:.|....|..|..:....|.|::|.|. || ..::
Human 2415 AVESTHPSSPGF----EDCSSSEATTPVAVQHIRPARVKRRKQSPV---------PA----LPIV 2462
Fly 2518 GQIMEMGFTRRTVELALKQL---SLQAEIMPTPEQIVQWILEHPDVCANTIEE-DTLPLASSASS 2578
.|:|||||:||.:|.|||.| |..|..:|..|.:|.|:|:|.|:....:.: ||: |...|
Human 2463 VQLMEMGFSRRNIEFALKSLTGASGNASSLPGVEALVGWLLDHSDIQVTELSDADTV---SDEYS 2524
Fly 2579 HDPEADSDNECPSSNSTTSSSTSSDTVEGQPMAVSGPAPPVKFESRKDFQTADLYALYVRGLVRP 2643
.:...:..::...|.||.:..|.|.| ::.|.||.:.|.||:|||..::.
Human 2525 DEEVVEDVDDAAYSMSTGAVVTESQT----------------YKKRADFLSNDDYAVYVRENIQV 2573
Fly 2644 GMTVRCCRDFEEIKQGDMGTVLIVDTEGLHDLNVQVDWRNHGSTYWVCFVHIELVEAAQTHHQPR 2708
||.|||||.:||:.:||:|.|:.:|.:||||||||.||:..|.||||.::|:||: ..
Human 2574 GMMVRCCRAYEEVCEGDVGKVIKLDRDGLHDLNVQCDWQQKGGTYWVRYIHVELI--------GY 2630
Fly 2709 PPP-----IAVGARVRLRTSSLRYGMLCPLRLGRSQGSSAIGVVS--SVRSKQLTVDFPDQPAWQ 2766
||| |.:|.:||::.| :..|.....|....::|||. |...|.:.||||.|..|.
Human 2631 PPPSSSSHIKIGDKVRVKAS-----VTTPKYKWGSVTHQSVGVVKAFSANGKDIIVDFPQQSHWT 2690
Fly 2767 GHINEVELVASQPTSATLPSLGDSCSQMP------------------------------------ 2795
|.::|:|||.|.....|. |.|...|
Human 2691 GLLSEMELVPSIHPGVTC----DGCQMFPINGSRFKCRNCDDFDFCETCFKTKKHNTRHTFGRIN 2751
Fly 2796 -----------------------PSDLIEDWSRCIRSLTVSSNEAAAKHLLNGSNQPWQSCSSGP 2837
|..|::.|||.::||.|||:...|..|::||...||| |...
Human 2752 EPGQSAVFCGRSGKQLKRCHSSQPGMLLDSWSRMVKSLNVSSSVNQASRLIDGSEPCWQS-SGSQ 2815
Fly 2838 CRHWIRLELHDRILVHSLTLKVSPEDHSHMPSLLEIRVGDCVDSLKEYTWIPVPAGASRVLLMQQ 2902
.:||||||:...:|||.|.:.|.|.|.|:||||:.:..|:.:::|.|...|.:....:.|.|:..
Human 2816 GKHWIRLEIFPDVLVHRLKMIVDPADSSYMPSLVVVSGGNSLNNLIELKTININPSDTTVPLLND 2880
Fly 2903 VPTYYPWVEVVVKQCQNNGIQCKIHGIKFVG--RRQQPDLQHILANAQFLASEYSAGVGPGSTAG 2965
...|:.::|:.:|||:::||.|||||:..:| |.::.| ||...||||:..........:|
Human 2881 CTEYHRYIEIAIKQCRSSGIDCKIHGLILLGRIRAEEED----LAAVPFLASDNEEEEDEKGNSG 2941
Fly 2966 -------AGAVSTSHEEAAAAPEQDLPCTVMVWGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIH 3023
||. |:||. :...|.|||||||:|||||||||:|||:||:|:|.|..:.
Human 2942 SLIRKKAAGL------ESAAT----IRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQ 2996
Fly 3024 IAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTH-NVPLPHQLPVLRQYVVKKVAVHSGGKHALA 3087
:||||||||.|:.:||||||||.||||||||::. .||:|.|:..|..||||||||||||:||.|
Human 2997 VAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATA 3061
Fly 3088 LTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLG 3152
||:||||||||||:||||||.:|...|||||:|||:.|:|||:|||||||||::|.|||||||||
Human 3062 LTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLG 3126
Fly 3153 EYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSE 3217
|||||||||||||||||:|..|.|.||:|||||||||||||||::|.||||||||||||||||||
Human 3127 EYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSE 3191
Fly 3218 GSDTPHEIERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRG 3282
|.:.|..||||:|.||.|||||||||||||::|.|||||||||:|||||.|.||||||.:.||||
Human 3192 GCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRG 3256
Fly 3283 RRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVACGSSHS 3347
::::||||||||||||||:|||||||||||||||:|.|.||:||.||.||:...:.|||||||||
Human 3257 KKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHS 3321
Fly 3348 IAWGLPNASSDEEKRGPVPFSSTRDPLGGSSLGI-YEAETMQTLKQ-----EAKPLNQSSLSE-S 3405
:||...:.::..... ||.|.:.|||||.|.||: .:|::.....: .:|| |:.||:: .
Human 3322 VAWTTVDVATPSVHE-PVLFQTARDPLGASYLGVPSDADSSAASNKISGASNSKP-NRPSLAKIL 3384
Fly 3406 LALETPAARQAALGHVLRAMSILQARQLIVAALTSHSKVNFKERGAVGGEEDHLIGGPIMGAPLQ 3470
|:|:...|:|.||.|:|.|:.|:.||..:|.||...:.: ||::
Human 3385 LSLDGNLAKQQALSHILTALQIMYARDAVVGALMPAAMI----------------------APVE 3427
Fly 3471 LAETIAQGGGEAPADATDAGLQEHSPEAAVDALTGGMSG-----GANTLPPLSAGP-------LS 3523
.... ...||:||: |:...|:| ..:....||..| :|
Human 3428 CPSF----SSAAPSDAS--------------AMASPMNGEECMLAVDIEDRLSPNPWQEKREIVS 3474
Fly 3524 AFQSLTGSLSMSGSLSSSALPQHKHSRMSASAMSVMAATMTQQEEMLSHISHCHG-----LDDFG 3583
:..::|.|.....:.|:||.|....:. ...|.|::|.|||:.:|.:...:...| ||:|.
Human 3475 SEDAVTPSAVTPSAPSASARPFIPVTD-DLGAASIIAETMTKTKEDVESQNKAAGPEPQALDEFT 3538
Fly 3584 GLLGEPEAKSLVELLKLAVCGRCGPPSTSQTIADTLISLGAGTPAVAAMLLETCITELEDLCTSR 3648
.||...:.:.:|:||||:||.|.|... ...::..|..:|...|.||.||||.|:|||||:.|..
Human 3539 SLLIADDTRVVVDLLKLSVCSRAGDRG-RDVLSAVLSGMGTAYPQVADMLLELCVTELEDVATDS 3602
Fly 3649 HCLGKL-PKPVMQESSHPYVDNVNVTGVVRIPGAEMLRLEFDSQCSTEKRNDPLVIMDGTGRVLA 3712
.. |:| .:||:.||||||.|:.:.:|.|:|||||.||:|||.|||||:|:|||.:|||..|:::
Human 3603 QS-GRLSSQPVVVESSHPYTDDTSTSGTVKIPGAEGLRVEFDRQCSTERRHDPLTVMDGVNRIVS 3666
Fly 3713 MRSGREFAHWAPEIRVLGDELRWKFSSDSSVNGWGWRFWVHAIMPAATLGESGSDRAVLSQPSMA 3777
:|||||::.|:.|:|:.||||:|||.||.|||||||||.|:.|||||...|..|||.|||.|||.
Human 3667 VRSGREWSDWSSELRIPGDELKWKFISDGSVNGWGWRFTVYPIMPAAGPKELLSDRCVLSCPSMD 3731
Fly 3778 LVMSLLDSRL-APRQPSVLLRLASALAACSQLGALTTAQRIWSLRKLHAVLLLE----------- 3830
||..|||.|| .....|::.|||::||||:||.||..:.|:|:|::|..:|..|
Human 3732 LVTCLLDFRLNLASNRSIVPRLAASLAACAQLSALAASHRMWALQRLRKLLTTEFGQSININRLL 3796
Fly 3831 -------QAPRPQDPSLSTLLQPLIPELLRQYEYEEPQVRGGIHLMHSDYFKTLAALACDMQLDA 3888
:|......:|:.|::.|...|.||:|||:|.||||..|:||.:||.|.|||||::||
Human 3797 GENDGETRALSFTGSALAALVKGLPEALQRQFEYEDPIVRGGKQLLHSPFFKVLVALACDLELD- 3860
Fly 3889 ALPATSSSSSSSAAPGAISSTGDVHKWAWFKRYCIAVRVAQSLIRRTELPRAFCLEVRKKFAEML 3953
.||..: :.||||||:|||:|.|||.:|.:||.|||.|..||.||..|::
Human 3861 TLPCCA----------------ETHKWAWFRRYCMASRVAVALDKRTPLPRLFLDEVAKKIRELM 3909
Fly 3954 PSSSSNSNANPGCQSPGASMLNSTTSLSSSTVSNVSPPPGITGEQPDLHCHAHQLESTSTLLHED 4018
..| |..| :|||.
Human 3910 ADS----------------------------------------ENMD-------------VLHES 3921
Fly 4019 HTLFQAPHDAQLLQWLNRRPDDWALSWGGASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLR 4083
|.:|:...|.||:||:|||||||.||.||:.|||||||||||||||:||:::|.|||||||:.||
Human 3922 HDIFKREQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLR 3986
Fly 4084 PVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHC 4148
||||.||||:|||||.||||:|||||:|||||:||::|.:.||||.|:||||:||||||||||||
Human 3987 PVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHC 4051
Fly 4149 LALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWG 4213
|||::|||||:|||.||||||||||...|||:::|.|.|:.|.|:|.|.||||.:||:|.:.|||
Human 4052 LALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWG 4116
Fly 4214 KGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGG 4278
|||||||||.||||||:|||||||.|:|.:|||||||||||||:||||.||||||||||||||||
Human 4117 KGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGG 4181
Fly 4279 SDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAAL 4343
|||||:|.||:||.||||||||||||||||||||||||||||||:|||||||.||||||::|..|
Human 4182 SDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGL 4246
Fly 4344 QGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSA 4408
||||:|:|||||||||.|::.||||||||||||||||||..||||||||||||||.:.:|.||||
Human 4247 QGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSA 4311
Fly 4409 HTLALSTSQLSERLRPLPNPPLEYDLVRDLAPEALHARLILLHHFSELVCPCLAMLPISGDL--- 4470
||||.|||:.:...:.....|:||:.::::...||..||:||||.|||.|||:.|..:.|.|
Human 4312 HTLAWSTSKPASAGKLPAQVPMEYNHLQEIPIIALRNRLLLLHHLSELFCPCIPMFDLEGSLDET 4376
Fly 4471 ----SLG--ALKDVLVYNIKEAAFRKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGM 4529
|:| .|:.:|:...||||||||:|.|||||:|||||:|||||||||||:: .||||.||.
Human 4377 GLGPSVGFDTLRGILISQGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSK-GGLAGPDGT 4440
Fly 4530 KSVFGQMVQKLPLLTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTP 4594
|||||||..|:.....::|.||||||||||||||||||||||||||||:|:|||||..||||.||
Human 4441 KSVFGQMCAKMSSFGPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTP 4505
Fly 4595 NGRGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPT 4659
|||.|:||||||:||.|...:.:..:||||||||:|||:|||||||:|||||||:||.|..|...
Human 4506 NGRDESGANRDCYLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIA 4570
Fly 4660 DLTEVDRDYVAGLLCIRNMDDDPKLFTALELPFSTSSARGHEVPLSTRYTHISPRNRAEYVRLAL 4724
||:|||:|::.||:.||:.:...:.|.|:.|||:..||.|.::.||:::|||:..|||||||||:
Human 4571 DLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFTVPSASGQDIQLSSKHTHITLDNRAEYVRLAI 4635
Fly 4725 GFRLHEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSAL 4789
.:|||||||||.|||:||::|:||||||||:..||:.||||||||||.||||||||||.:||::|
Human 4636 NYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPSASL 4700
Fly 4790 VTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEK-NPPDHFLPESYTCFFL 4853
:.|||||||.|:|.||||||||||||||||||||||||||||:|||:| ||||||||||||||||
Human 4701 IQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFL 4765
Fly 4854 LKMPRYSCKAVLLEKLKYAIHFCKSIDTDEYARVAM-GEPT--EATGSEDNSDLESVAS 4909
||:||||||.||.||||||||||||||||:|||:|: |||. :::...||.|::|.||
Human 4766 LKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARIALTGEPAADDSSDDSDNEDVDSFAS 4824
| 
