DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and GAS7

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_958839.1 Gene:GAS7 / 8522 HGNCID:4169 Length:476 Species:Homo sapiens


Alignment Length:594 Identity:113/594 - (19%)
Similarity:182/594 - (30%) Gaps:262/594 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly  1234 GLRWAR-LFLPLLRVLDRLNRALGEGELRDGDDMGW-----------PGIICRGGPKGGPPPADP 1286
            |||:|. ..:.||:|.|   ....|||..|| ..||           ||::       .|||.: 
Human    20 GLRFAAGELITLLQVPD---GGWWEGEKEDG-LRGWFPASYVQLLEKPGMV-------PPPPGE- 72

  Fly  1287 ETHYVRRADMENLLLDGSRCIILAGYVCDLSGYNCESETLRSVLDSGLGKDLTAEMSSQVHRTAM 1351
                                               ||:|:  :|..|    ..:.:|.|..|   
Human    73 -----------------------------------ESQTV--ILPPG----WQSYLSPQGRR--- 93

  Fly  1352 EHILEHHKLGKYMVQAST-----EEKSSAPG--PSRLTHFSSECALAQLLGLVANLMCSGPALQP 1409
                       |.|..:|     |..||:||  .|..:|.||      |...|.....||....|
Human    94 -----------YYVNTTTNETTWERPSSSPGIPASPGSHRSS------LPPTVNGYHASGTPAHP 141

  Fly  1410 AELQCRQLDKSSLLSGGLQLLQPSNPFDEEKGEARSSHSC----HSTAGNTPTELPPPLPMQQQL 1470
            .|.....:.||   :|..|.|..|:|..::..|...:.:|    |          |..:|.||.|
Human   142 PETAHMSVRKS---TGDSQNLGSSSPSKKQSKENTITINCVTFPH----------PDTMPEQQLL 193

  Fly  1471 AP-----------------GRGK--------------SQLQLRADAFISGLAE---------ARV 1495
            .|                 |.|.              .|:|.....||....:         |::
Human   194 KPTEWSYCDYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEDYAKNLAKL 258

  Fly  1496 SEPPVA---------AWLALTERY-----------CKAHN------LMWHQEF-----ATEHPVQ 1529
            |:..:|         ||..:.:..           .|.|:      :.:.:.|     ..:|.:.
Human   259 SQNSLASQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHHIA 323

  Fly  1530 ELERLLSA------------------VLIRHQYLGGLVLNALETEVPPPR----QLG-EIIRLVH 1571
            :|.:.|::                  :.::.|.|...:.|..|.::...|    |.| :::|.|.
Human   324 DLRKQLASRYASVEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRKSTQAGDDLMRCVD 388

  Fly  1572 -----QAKWSVVRTRQQLNRSYKEVCAPILERLRFLLYEVRPAISPQQRGLRRLPILQRPPRFKM 1631
                 |:||            ::|:....||                   |.||.:    .|.:|
Human   389 LYNQAQSKW------------FEEMVTTTLE-------------------LERLEV----ERVEM 418

  Fly  1632 LVRRLLQ--ELRSSRQPAKPEDLLNASIQQEQEKKPQSMPKQELEEQEEEETLLRRLNERQIHGE 1694
            :.:.|.|  :||..      .|:.|.|..:     |.....::::..::.|..:|.      |..
Human   419 IRQHLCQYTQLRHE------TDMFNQSTVE-----PVDQLLRKVDPAKDRELWVRE------HKT 466

  Fly  1695 GELDPALMQ 1703
            |.:.|..|:
Human   467 GNIRPVDME 475

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597 8/72 (11%)
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
GAS7NP_958839.1 SH3_GAS7 5..57 CDD:212763 15/40 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 100..171 23/79 (29%)
WW_FCH_linker 109..201 CDD:374680 30/110 (27%)
F-BAR_GAS7 214..446 CDD:153333 44/277 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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