DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HERC2 and FMP25

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_013178.1	Gene:	FMP25 / 850766	SGDID:	S000004067	Length:	583	Species:	Saccharomyces cerevisiae

Alignment Length:	416	Identity:	85/416 - (20%)
Similarity:	135/416 - (32%)	Gaps:	170/416 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  2991 WGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACGEG--------T 3047
            |.|...:...|.:|.|             |.:....||..|.::|..||.|.|..|        :
Yeast   280 WKLQTNQIFNGKEGEK-------------RVVQFDAGSHHLVLLSNLGKAYCCATGNDQKQAQVS 331

  Fly  3048 NGRLGLGVTHNVPLPHQLPVLRQY-------VVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKL 3105
            .|:.|            :|...|:       .:.::.:.:..||              ||||
Yeast   332 KGQFG------------IPTFSQFDEFPPNNQLFEIELLNKFKH--------------EGED--- 367

  Fly  3106 GHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLG--HGDNTTQLK- 3167
                           .:|.::|:.:||||.|:.||...||:|.:|...:|:|.  ...|...:.
Yeast   368 ---------------VVRKREIKKIACGSYHTLAIDKTGEIYAFGWNRFGQLALPISYNLEYVSF 417

  Fly  3168 PKLVT--------ALAGRRVVQVACGSRDAQTLAL-------TEDGAVFSWGDGDFGKLGRGGSE 3217
            |:.||        .:...:.|.:.|   |.:|..:       |.|...|::|:|.||:||....:
Yeast   418 PRSVTHAFKPHFPGMTNWKCVDIHC---DDETSFVTIRKPGSTSDHHYFAFGNGLFGELGNNTFK 479

  Fly  3218 GSD-TPHEIERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLR 3281
            .|. .|.:|:              .....||.    |:.|.
Yeast   480 NSQCDPIKIK--------------SDDKKLTN----WSCGS------------------------ 502

  Fly  3282 GRRVIHVAVGALHCL--AVTDAGQVYAWGDNDHGQQGSG-NTFVNKKPALV----------IGLD 3333
                        ||:  ......:|.|||:|||||.|.| .|....||..:          ..||
Yeast   503 ------------HCVFTETEQENEVIAWGNNDHGQLGIGKKTMKCAKPMNIPEVLKPGQDTTDLD 555

  Fly  3334 AVFVNR---------VACGSSHSIAW 3350
            :::.::         |..|:...:.|
Yeast   556 SIYNSKLHLKKEQRVVTNGNKSCLYW 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826	11/65 (17%)
		RCC1	3091..3140	CDD:278826	11/48 (23%)
		RCC1	3144..3194	CDD:278826	14/60 (23%)
		RCC1	3197..3246	CDD:278826	11/49 (22%)
		RCC1	3250..3298	CDD:278826	4/49 (8%)
		RCC1	3302..3350	CDD:278826	18/67 (27%)
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
FMP25	NP_013178.1	ATS1	8..577	CDD:227511	84/410 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810