DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and AT1G69710

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_177129.2	Gene:	AT1G69710 / 843307	AraportID:	AT1G69710	Length:	1041	Species:	Arabidopsis thaliana

Alignment Length:	950	Identity:	225/950 - (23%)
Similarity:	364/950 - (38%)	Gaps:	196/950 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  3780 MSLLDSRLAPRQPSVLLRLASALAACSQLGALTTA-------QRIWSLRKLHAVLLLEQAPRPQ- 3836
            |.:|:.||              .||.|...:|.|:       |.|.||:|...:|...:..:|:
plant     1 MCILELRL--------------FAAASMADSLRTSFSERDVEQAITSLKKGSYLLKYGRRGKPKF 51

  Fly  3837 -------DPS--------------LSTLLQPLIP----ELLRQYEYEEPQVRGGIHLMHSDYFKT 3876
                   |.|              ||.:|: ::|    ...::|...|.:            :::
plant    52 CPFQLTSDESALVWYSGKEEKQIKLSQVLR-IVPGQRTPTFKRYPRPEKE------------YQS 103

  Fly  3877 LAALACDMQLDAALPATSSSSSSSAAPGAISSTGDVHKWAWFKRYCIAVRVAQSLIRRTELPRAF 3941
            .:.:..|..||........:........::.:...|.||.         ...:..|...|.|...
plant   104 FSLICPDRSLDLICKDKDEAEVWVVGLKSLITRVKVSKWK---------TTIKPEITSAECPTPH 159

  Fly  3942 CLEVRKKFAEML-----PSSSSNSNANPG--------CQSPGASMLNSTTSLSSSTVSNVSPPPG 3993
            ...| ..|..:|     ||:.:::....|        ..:|.::  |:.|..|.:.....||.|.
plant   160 ARRV-SPFVTILDQVIQPSNETSTQTRLGKVFSDIVAITAPPSN--NNQTEASGNLFCPFSPTPA 221

  Fly  3994 ITGEQPDLHCHAH---QLESTSTLLHEDHTLFQAPHDAQLLQWLNRRPDDWALSWGGASTIYGWG 4055
             ..|..:|....:   :|..:|.:....|..:....||                   ...::.||
plant   222 -NVENSNLRFSTNDPFRLSLSSAVSTSSHGSYHEDFDA-------------------LGDVFVWG 266

  Fly  4056 HN-HRGQLGGLEGSRIKT------PTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGR 4113
            .: ..|.|.|...|...|      |...|:..:|....:|.|:.....||..|::|:.|.|.||:
plant   267 ESISDGVLSGTGNSLNSTTEDALLPKALESTIVLDAQNIACGKCHAVLVTKQGEIFSWGEGKGGK 331

  Fly  4114 LGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDG--KLGHGNRMSY 4176
            ||.|.......|..:.|::.:..|.:|  .|..|..|:|..|::|:||:|...  .|||||..|.
plant   332 LGHGLETDAQKPKFISSVRGLGFKSLA--CGDFHTCAITQSGDLYSWGDGTHNVDLLGHGNESSC 394

  Fly  4177 DRPKLVE-HLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGY 4240
            ..||.|. .|.|:.|:|:|||..|:|.:.:||.:.|:|.|.:|.|||||......|:.||:|:|.
plant   395 WIPKRVTGDLQGLYVSDVACGPWHTAVVASSGQLFTFGDGTFGALGHGDRRSTSVPREVESLIGL 459

  Fly  4241 RAIDIACGS-GDAQTLCITDD----------DNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGL 4294
            ....:|||. ..|..:.:|::          ..|::||||:.|:||.|.:|...||..:.||...
plant   460 IVTKVACGVWHTAAVVEVTNEASEAEVDSSRGQVFTWGDGEKGQLGHGDNDTKLLPECVISLTNE 524

  Fly  4295 GVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAA-LQGKKIISIATGSLHC 4358
            .:.:|.||...:|:.|..|.|||.|...:.:||:.:... ..|::|.. :....:..||.||.|.
plant   525 NICQVACGHSLTVSRTSRGHVYTMGSTAYGQLGNPTAKG-NFPERVEGDIVEASVEEIACGSYHV 588

  Fly  4359 VACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQLSERLR 4423
            ...:...|:||||....||||.|.|...:.|.:|..|:.|.:..:||||..|..:...:..
plant   589 AVLTSKSEIYTWGKGLNGQLGHGNVENKREPAVVGFLREKQVKAITCGSNFTAVICVHKWV---- 649

  Fly  4424 PLPNPPLEYDLVRDLA-PEALHARLILLHHFSELVCP-CLAMLPISGDLSLGALKDVLVYNIKEA 4486
                |..|:.|..... |.....:....::...:.|. |.:...:...|:....|.   |.:...
plant   650 ----PGSEHSLCAGCRNPFNFRRKRHNCYNCGLVFCKVCSSRKSLRAALAPDMNKP---YRVCYG 707

  Fly  4487 AFRKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPLLTQEALALP 4551
            .|     |.:.:.::..|     .....|:|...|.....|         |.:...|||:.|::.
plant   708 CF-----TKLKKSRESSP-----STPTSRTRKLLNMRKSTD---------VSERDSLTQKFLSVN 753

  Fly  4552 HRVWKVKFVGESVDDCGGGYSESIAEMCD---ELQNGSV-PLL------INTPNGRGEAGANRDC 4606
            .|:        |..|....|||......|   |:.|.:| |.:      :.:|..:|..
plant   754 ARL--------SSADSSLHYSERRHHRRDLKPEVNNSNVFPSMNGSLQPVGSPFSKGST------ 804

  Fly  4607 FLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEP 4646
                 .|..:.:..|.:..|  .|::.||.||:|:....|
plant   805 -----ALPKIPKNMMVKIPG--SGMSSRTTSPVSVKSTSP 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274	11/29 (38%)
		RCC1	4154..4203	CDD:278826	23/51 (45%)
		RCC1	4206..4257	CDD:278826	20/51 (39%)
		RCC1	4260..4309	CDD:278826	18/58 (31%)
		RCC1	4312..4360	CDD:278826	14/48 (29%)
		RCC1	4364..4413	CDD:278826	20/48 (42%)
		HECTc	4509..4880	CDD:238033	31/147 (21%)
		HECTc	4553..4878	CDD:214523	22/103 (21%)
AT1G69710	NP_177129.2	PH_PLC_plant-like	25..135	CDD:270171	18/122 (15%)
		RCC1_2	354..381	CDD:290274	11/28 (39%)
		RCC1	370..422	CDD:278826	23/51 (45%)
		RCC1	425..474	CDD:278826	20/48 (42%)
		RCC1	491..537	CDD:278826	17/45 (38%)
		RCC1	543..591	CDD:278826	14/48 (29%)
		RCC1	596..643	CDD:278826	20/46 (43%)
		FYVE	646..714	CDD:214499	11/83 (13%)
		DUF4200	838..936	CDD:290574	224/949 (24%)
		BRX_N	896..>921	CDD:290432
		BRX	981..1035	CDD:285568
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3500
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820